Metabonomics and Intensive Care

Antcliffe, David; Gordon, Anthony

doi:10.1007/978-3-319-27349-5_28

Cited by 2 publications

(4 citation statements)

References 42 publications

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“…In the intensive care unit, researchers have begun to define clinically feasible assays to rapidly detect sepsis through accumulation of specific metabolites in blood. 5…”

Section: Medicine and Society: The Precision Medicine Eramentioning

confidence: 99%

“…Researchers in gastroenterology are using precision medicine tools to improve biomarkers for numerous diseases and are interrogating the microbiome environment in gastrointestinal disease. In the intensive care unit, researchers have begun to define clinically feasible assays to rapidly detect sepsis through accumulation of specific metabolites in blood …”

Section: Introductionmentioning

confidence: 99%

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Precision medicine in pediatric oncology: Lessons learned and next steps

Mody

Prensner

Everett

et al. 2016

Pediatric Blood & Cancer

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The maturation of genomic technologies has enabled new discoveries in disease pathogenesis as well as new approaches to patient care. In pediatric oncology, patients may now receive individualized genomic analysis to identify molecular aberrations of relevance for diagnosis and/or treatment. In this context, several recent clinical studies have begun to explore the feasibility and utility of genomics-driven precision medicine. Here, we review the major developments in this field, discuss current limitations, and explore aspects of the clinical implementation of precision medicine, which lack consensus. Lastly, we discuss ongoing scientific efforts in this arena, which may yield future clinical applications.

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“…In the intensive care unit, researchers have begun to define clinically feasible assays to rapidly detect sepsis through accumulation of specific metabolites in blood. 5…”

Section: Medicine and Society: The Precision Medicine Eramentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Precision medicine in pediatric oncology: Lessons learned and next steps

Mody

Prensner

Everett

et al. 2016

Pediatric Blood & Cancer

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“…Targeted metabolomics has been used to discriminate noninfectious systemic inflammatory response syndrome (SIRS) from infections SIRS [9]. Untargeted approaches have identified significant, severe metabolic derangements that are associated with mortality [10,11].…”

Section: Introductionmentioning

confidence: 99%

“…Since the metabolome is closest to the phenome, it is more likely to reflect the individual patient's state at any given time than other -omes. As others have pointed out, issues of heterogeneity and variability make biomarker studies problematic [6,10]. A first step is to examine how metabolic profiles differ with different underlying diseases and with illness severity to get a better sense of this variability.…”

Section: Introductionmentioning

confidence: 99%

Serum Metabolomics as a Powerful Tool in Distinguishing Trauma from Other Critical Illness Conditions

Lusczek¹

2020

Metabolomics - New Insights Into Biology and Medicine

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Critical illness is highly variable, complicating patient care and recovery. We have previously used metabolomics to investigate several causes of intensive care unit admission, seeking to assess changes in metabolism occurring with each condition. We present a meta-analysis of these serum metabolomes, exploring how the metabolomes differ with each condition. We also present how mass spectrometry-based metabolomics could be used for predictive monitoring. Serum metabolites were previously quantified using nuclear magnetic resonance spectroscopy in patients with traumatic injury, respiratory failure, pancreatitis, and combat trauma. Healthy controls are also included. Spectral features were analyzed with principal component analysis (PCA) to explore patterns in patients' underlying conditions. PCA suggests trauma metabolic profiles, particularly combat casualties, differ from other conditions. Principal components 2 and 3, accounting for 16% of the variation in the model, distinguish samples obtained from trauma patients. Metabolomics is a powerful tool for quantifying variability in critical illness, highlighting trauma as separate from other conditions. This observation is in line with the-omics literature, which has described a massive global "genomic storm" in response to severe injury. Mass spectrometry highlights this extreme variability, which occurs in ICU patients but not healthy controls. With new technology, metabolomics could be used to bring faster, individualized patient care to the ICU.

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Metabonomics and Intensive Care

Abstract: This article is one of ten reviews selected

Cited by 2 publications

References 42 publications

Precision medicine in pediatric oncology: Lessons learned and next steps

Precision medicine in pediatric oncology: Lessons learned and next steps

Serum Metabolomics as a Powerful Tool in Distinguishing Trauma from Other Critical Illness Conditions

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