Metachronous second primary malignant fibrous histiocytoma in two skeletal muscles

Abstract

The first recorded case of a metachronous second primary malignant fibrous histiocytoma (MFH) of soft tissue is presented. The patient, who has been followed every two months since the treatment of his buttock sarcoma by neoadjuvant therapy, is free of disease 24 months later. The clinical presentations, different histologies, and DNA contents of these two MFHs are consistent with metachronous primary sarcomas. The literature on second primary neoplasms is discussed.

Metachronous Malignant Fibrous Histiocytoma of Skull

“…Similarly, metachronous multicentric MFH of soft tissue is also rare. Soft tissue MFH with metachronous lesions was reported for the first time by Wolf et al developing over 24 years and is a rare occurrence 17 . Management of MFH includes surgical excision followed by chemotherapy and/or radiation.…”