Metal accumulation and detoxification in humans

Chan, Hing Man

doi:10.1007/978-1-4757-2761-6_13

Cited by 9 publications

(9 citation statements)

References 92 publications

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“…The dorsal root ganglia are well invaded, whereas the Purkinje cells of the cerebellum, ventral horn motor cells, and cerebellar granule cells show fewer invasions. In contrast, mercuric chloride intoxication is highest in the dorsal root ganglia, followed by the ventral horn motor neurons, calcarine cortical neurons, and the granule cells of the cerebellum (Chan, 1998).…”

Section: Genotoxic Carcinogenic and Teratogenic Effects Of Mercurymentioning

confidence: 85%

“…Hair analyses of patients with mercury-induced cardiomyopathy measured mercury levels 20,000 times higher than in controls (Harada et al, 1998;Frustaci et al, 1999). Other neurological problems such as tremors, insomnia, polyneuropathy, paresthesia, emotional lability, irritability, personality changes, headache, weakness, blurred vision, dysarthria or speech impairment, slowed mental response, and unsteady gait have been observed (Chang et al, 1995;Myers et al, 1995;Urbach et al, 1992;Chan, 1998). Many cases have been reported of infants exposed to phenylmercury used as fungicidal diaper rinse and of chil-dren exposed to mercury in interior latex paint (Agocs et al, 1990;Langford and Ferner, 1999).…”

Section: Clinicopathological Effectsmentioning

confidence: 97%

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Review: Environmental exposure to mercury and its toxicopathologic implications for public health

Tchounwou

Ayensu

Ninashvili

et al. 2003

Environmental Toxicology

1,219

620

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Mercury is a toxic and hazardous metal that occurs naturally in the earth's crust. Natural phenomena such as erosion and volcanic eruptions, and anthropogenic activities like metal smelting and industrial production and use may lead to substantial contamination of the environment with mercury. Through consumption of mercury in food, the populations of many areas, particularly in the developing world, have been confronted with catastrophic outbreaks of mercury-induced diseases and mortality. Countries such as Japan, Iraq, Ghana, the Seychelles, and the Faroe Islands have faced such epidemics, which have unraveled the insidious and debilitating nature of mercury poisoning. Its creeping neurotoxicity is highly devastating, particularly in the central and peripheral nervous systems of children. Central nervous system defects and erethism as well as arrythmias, cardiomyopathies, and kidney damage have been associated with mercury exposure. Necrotizing bronchitis and pneumonitis arising from inhalation of mercury vapor can result in respiratory failure. Mercury is also considered a potent immunostimulant and -suppressant, depending on exposure dose and individual susceptibility, producing a number of pathologic sequelae including lymphoproliferation, hypergammaglobulinemia, and total systemic hyper- and hyporeactivities. In this review we discuss the sources of mercury and the potential for human exposure; its biogeochemical cycling in the environment; its systemic, immunotoxic, genotoxic/carcinogenic, and teratogenic health effects; and the dietary influences on its toxicity; as well as the important considerations in risk assessment and management of mercury poisoning.

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Section: Genotoxic Carcinogenic and Teratogenic Effects Of Mercurymentioning

confidence: 85%

Section: Clinicopathological Effectsmentioning

confidence: 97%

Review: Environmental exposure to mercury and its toxicopathologic implications for public health

Tchounwou

Ayensu

Ninashvili

et al. 2003

Environmental Toxicology

1,219

620

View full text Add to dashboard Cite

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“…The values in dotted boxes are above the ADI set by the EPA. The countries' average yearly fish consumption per capita (kg f resh weight) is given under each country considered (Antoine 1995, Mauritius Central Statistics Office 2002, FAO & SIDP Oct. 2005 sensitive to Hg toxicity, for nursing mothers, and for children less than 10 years (Chan, 1998;DHHS and EPA, 2004). The French (AFSSA) and the Canadian health agencies follow the same guidelines as the WHO, whereas the U.S. FDA and U.S. Environmental Protection Agency (EPA) have set more restrictive ADI limits for MeHg (0.4 and 0.1 µg.day −1 .kg −1 body weight respectively for all the population) (Hirsch, 2002).…”

Section: Risk To the Fish And Their Predatorsmentioning

confidence: 99%

Mercury content in commercial pelagic fish and its risk assessment in the Western Indian Ocean

Kojadinovic

Potier

Corre³

et al. 2006

Science of The Total Environment

123

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As top predators of pelagic food webs, large fish naturally bioaccumulate mercury (Hg). Determining Hg burdens in commercialized fish is essential considering the concern about effects of contaminants on human health and the legal thresholds that are therefore set for local consumption and/or exportation. Total Hg levels were measured in the muscular tissue of 183 fish of five commercially important species from the tropical zone of the Western Indian Ocean. All individuals were measured and sexed in order to study the impregnation of Hg with size and sex within each species. Values of Hg found in this part of the Indian Ocean were comparable to Hg in muscular tissue of the same species studied in other areas. The highest Hg levels were noted in Swordfish (Xiphias gladius) caught in waters surrounding Reunion Island (3.97 ± 2.67 µg.g −1 dry weight). Following the Swordfish, in decreasing order of Hg content, were the Yellowfin Tuna (Thunnus albacares) and the Skipjack (Katsuwonus pelamis), then the Common Dolphinfish (Coryphaena hippurus) and the Wahoo (Acanthocybium solandri). In the North of the Mozambique Channel, Swordfish had higher Hg levels than Yellowfin Tunas, and Dolphinfish exhibited intermediate Hg levels. The size of a fish was a determinating factor of its Hg burden, as was the species. Differences in size-normalized Hg levels were observed between the two study zones for Swordfish and Common Dolphinfish. Sex, in contrast, did not influence Hg levels suggesting that females and males have similar feeding habits. The muscular Hg levels presented here suggest that consumers of fish originating from the Western Indian Ocean should limit themselves to one Swordfish based meal per week, or one fish meal a day if they choose to eat tuna or Common Dolphinfish.

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“…The Food Agricultural Organization/ WHO Expert Committee on Food Additives recommends that the weekly intake not exceed 300 µg total Hg, with a maximum of 200 µg MMHg, which represents 3.3 µg/kg for a 60-kg male (5). Approximately 95% of MMHg is absorbed through the intestinal barrier (28); the biological half-life of organic Hg in humans is estimated at between 70 and 80 days (29). Dietary intake of Hg in the Wayana population is above this safety limit.…”

Section: Total Length (Cm)mentioning

confidence: 99%

Gold-Mining Activities and Mercury Contamination of Native Amerindian Communities in French Guiana: Key Role of Fish in Dietary Uptake

Frery¹,

Maury-Brachet²,

Maillot³

et al. 2001

Environmental Health Perspectives

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Metal accumulation and detoxification in humans

Cited by 9 publications

References 92 publications

Review: Environmental exposure to mercury and its toxicopathologic implications for public health

Review: Environmental exposure to mercury and its toxicopathologic implications for public health

Mercury content in commercial pelagic fish and its risk assessment in the Western Indian Ocean

Gold-Mining Activities and Mercury Contamination of Native Amerindian Communities in French Guiana: Key Role of Fish in Dietary Uptake

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