Metal cation responsive anionic microgels: behaviour towards biologically relevant divalent and trivalent ions

Chimisso, Vittoria; Conti, Simona; Kong, Phally; Fodor, Csaba; Meier, Wolfgang

doi:10.1039/d0sm01458c

Cited by 6 publications

(3 citation statements)

References 41 publications

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“…In salt-free solutions, like-charged polyelectrolytes repel each other, and concentration fluctuations are heavily suppressed compared to those in nonionic polymers. − Addition of 1:1 salts to solutions of polyelectrolytes results in increased electrostatic screening. This leads to a reduction of the chain dimensions, and polyelectrolytes adopt conformations similar to those of neutral polymers in good solvents. ,− Divalent salts are able to shrink chains to a larger extent at constant ionic strength. − This occurs because divalent counterions usually display enhanced binding to the polyelectrolyte backbone, which decreases the effective charge of the chain. , …”

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confidence: 99%

Solution Properties of Polyelectrolytes with Divalent Counterions

et al. 2021

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Divalent ions are known to strongly influence the phase behavior, conformation, and flow properties of polyelectrolytes in solution. Here, we report small-angle neutron scattering and viscosity data for the magnesium salt of polystyrene sulfonate (MgPSS) in salt-free water and compare these results with analogous measurements for NaPSS. In a dilute solution, both salts are found to exhibit a rod-like conformation for high degrees of polymerization, but the chain dimensions of MgPSS are significantly smaller than for NaPSS, which is consistent with the lower charge density of MgPSS found from conductivity data. In the semidilute regime, the correlation length scales as ξ ≃ 3.7c −1/2 nm for NaPSS and ξ ≃ 5.4c −1/2 nm for MgPSS. At high concentrations, deviations to weaker power laws are observed for both salts. The variation of the viscosity with the degree of polymerization (η sp ∼ N) is consistent with unentangled, Rouse-like dynamics. Fuoss-law-type behavior (η sp ∼ c 1/2 ) is observed at low polymer concentrations, which turns into a stretched exponential dependence at high c, perhaps due to an increase in the local friction experienced by polymer segments.

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Solution Properties of Polyelectrolytes with Divalent Counterions

et al. 2021

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“…These waterin-oil emulsions must be stabilized with surfactants that, together with the oil, must be removed through several washing steps after the microgels have been produced, thereby limiting the throughput of this technique and increasing the production costs [44]. Microgels can also be made through precipitation polymerization [58] or spray emulsification [59], yet with more stringent requirements in terms of material selection and precursor viscosity. A way to circumvent these shortcomings is to mechanically fragment bulk hydrogels [44,[60][61][62] for example using blenders [63], sieves [61], or cryomilling [62].…”

Section: Resultsmentioning

confidence: 99%

4d Printing of Metal-Reinforced Double Network Granular Hydrogels

Hirsch¹,

D’Onofrio²,

Guan³

et al. 2023

Preprint

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“…[185][186][187][188][189][190][191][192] In this complexation, these polysaccharides employ both carboxylate and hydroxyl groups in the binding of metal. 30,[193][194][195][196][197][198][199][200][201][202][203][204] Among the metals, complexation of iron is preferred with the stability constant approximating 10 4 M −1 . [202][203][204] By acting like organic ligands, these polysaccharides participate in iron homeostasis to enhance bioavailability of metal thus increasing import.…”

Section: Chronic Bronchitismentioning

confidence: 99%

Cigarette Smoke Particle-Induced Lung Injury and Iron Homeostasis

Ghio¹,

Pavlisko²,

Roggli³

et al. 2022

COPD

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It is proposed that the mechanistic basis for non-neoplastic lung injury with cigarette smoking is a disruption of iron homeostasis in cells after exposure to cigarette smoke particle (CSP). Following the complexation and sequestration of intracellular iron by CSP, the host response (eg, inflammation, mucus production, and fibrosis) attempts to reverse a functional metal deficiency. Clinical manifestations of this response can present as respiratory bronchiolitis, desquamative interstitial pneumonitis, pulmonary Langerhans' cell histiocytosis, asthma, pulmonary hypertension, chronic bronchitis, and pulmonary fibrosis. If the response is unsuccessful, the functional deficiency of iron progresses to irreversible cell death evident in emphysema and bronchiectasis. The subsequent clinical and pathological presentation is a continuum of lung injuries, which overlap and coexist with one another. Designating these non-neoplastic lung injuries after smoking as distinct disease processes fails to recognize shared relationships to each other and ultimately to CSP, as well as the common mechanistic pathway (ie, disruption of iron homeostasis).

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Metal cation responsive anionic microgels: behaviour towards biologically relevant divalent and trivalent ions

Abstract: Anionic poly(vinylcaprolactam-co-itaconicacid-co-dimethylitaconate) microgels were synthesized via dispersion polymerization and their responsiveness towards cations, namely Mg2+, Sr2+, Cu2+ and Fe3+ was investigated. The itaconic moeities chelate the metal ions which act...

Cited by 6 publications

References 41 publications

Solution Properties of Polyelectrolytes with Divalent Counterions

Solution Properties of Polyelectrolytes with Divalent Counterions

4d Printing of Metal-Reinforced Double Network Granular Hydrogels

Cigarette Smoke Particle-Induced Lung Injury and Iron Homeostasis

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