Metal‐Complex/DNA Conjugates: A Versatile Building Block for DNA Nanoarrays

Ghosh, Sumana; Defrancq, Éric

doi:10.1002/chem.201001590

Cited by 26 publications

(8 citation statements)

References 63 publications

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“…Insertion of spacers which act as transition metal binding units within DNA strands can also be used to introduce new structural elements. This topic has been reviewed, 68,69 and we refer readers to those articles. These spacer units will continue to serve a valuable role in various DNA technologies for many years to come, but the ease with which these insertions have been placed within the chain raises more possibilities in the organisation of functional unitsthis has been ably explored in the creation of DNA/chromophore hybrids.…”

Section: Non-nucleosidic Insertions In Nucleic Acidsmentioning

confidence: 99%

High definition polyphosphoesters: between nucleic acids and plastics

Appukutti

Serpell

2018

Polym. Chem.

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Section: Non-nucleosidic Insertions In Nucleic Acidsmentioning

confidence: 99%

High definition polyphosphoesters: between nucleic acids and plastics

Appukutti

Serpell

2018

Polym. Chem.

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“…In nucleic acids that have been modified chemically by attachment of chelating ligands, the ligands can act as coordination sites for metal ions, and while the nucleic acid itself is not necessarily in direct contact with them, these metals give unique properties to the DNA-based structures. Shionoya 89 and Defrancq 90 have published reviews on metal-base pairing in DNA.…”

Section: Coordination Of Metals To Chelates Incorporated Covalently I...mentioning

confidence: 99%

Interaction of metal complexes with nucleic acids

Suntharalingam

Vilar

2011

Annu. Rep. Prog. Chem., Sect. A: Inorg. Chem.

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This chapter, divided into three sections, reviews the literature reported during 2010 in the field of interaction of metal complexes with nucleic acids and complex formation between metals and coordinating moieties within nucleic acids. The first two sections focus on the interaction of metal complexes and ions with DNA and RNA, respectively, and are organised by mode of interaction. In the last section examples where transition metals occupy coordination sites covalently incorporated within nucleic acids strands' are discussed. HighlightsA series of achiral copper(II) complexes, when bound to duplex DNA, perform catalytic enantioselective hydration of enones. 1 The X-ray structure of a RNA polymerase II transcribing complex stalled at the monofunctional pyriplatin site has been resolved, providing an insight into the mechanism of transcription inhibition. 2 The first structural characterisation of a nucleic acid with a continuous run of metal modified base pairs has been reported. 3 A polyacrylamide hydrogel functionalised with a thymine rich DNA strand has been developed to detect and simultaneously remove toxic Hg II ions from water. 4 The first gold complex to interact with quadruplex DNA has been reported. 5 Cu II -salen metal-base pairs have been introduced inside the double helix of DNA; the stacked copper(II) square planar complexes display antiferromagnetic coupling. 6 Interaction of metal centres with DNAIn this section, the material has been organised by binding type; direct base coordination of the metal centre or non-covalent interactions such as intercalation, hydrogen bonding or electrostatic interactions.

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“…DNA molecules are well known for its stimuli‐responsive conformations, because of the inherent dynamic properties. DNA conformation can undergo the switch between randomly coiled strand and double helix, hairpin or multifolded secondary structures (e.g., quadruplex or aptamer‐substrate complex, triggered by external chemical stimuli, such as the complementary nucleic strand, metal ions, buffer pH, small molecules or proteins . The responsive conformational changes of DNA molecules are sequence‐dependent and have been employed in DNA machines, DNA‐based sensors, the molecular computing circuits etc.…”

Section: Introductionmentioning

confidence: 99%

Engineering the pH‐Responsive Catalytic Behavior of AuNPs by DNA

Zhan

Wang

et al. 2013

Small

116

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Noble metal nanoparticles have attracted much interest in the heterogeneous catalysis. Particularly, efficient manipulation of the responsive catalytic properties of the metal nanoparticles is an interesting topic. In this work, a simple and efficient strategy is developed to regulate the pH-responsive catalytic activities of glucose oxidase (GOx)-mimicking gold nanoparticles (AuNPs). Four DNA strands (regulating strands) that differ slightly in sequences are used to interact non-covalently with citrate-capped AuNPs, resulting in markedly distinct pH-dependent catalytic behavior of AuNPs. This is ascribed to the characteristic pH-induced conformational change of the DNA strands that leads to the different adsorption capability to the NPs surface, as demonstrated by pH-CD profiles of the respective DNA molecules. The pH-dependent catalysis of AuNPs is also encoded with structural information of the double-stranded DNA (including regulating strands and their complementary strands) that has conformation resistant or responsive to pH change. As a result, the catalysis can be programmed into an AND gate, a XNOR gate or a NOT gate, using pH and complementary strand as the inputs, the nanoparticle activity as the output and the regulating strands as the programs. This work can be expanded by engineering the catalytic behavior of noble metal nanoparticles to respond smartly to a variety of environmental stimuli, such as metal ions or light wavelengths. These results may provide insight into understanding ligand-regulated nanometallic catalysis.

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Metal‐Complex/DNA Conjugates: A Versatile Building Block for DNA Nanoarrays

Cited by 26 publications

References 63 publications

High definition polyphosphoesters: between nucleic acids and plastics

High definition polyphosphoesters: between nucleic acids and plastics

Interaction of metal complexes with nucleic acids

Engineering the pH‐Responsive Catalytic Behavior of AuNPs by DNA

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