Metal free Lewis acid promoted one-pot synthesis of 14-aryl-14H dibenzo [a,j] xanthenes and their simple biological evolution

Kusampally, Uppalaiah; Pagadala, Ramakanth; Kamatala, Chinna Rajanna

doi:10.1016/j.tetlet.2017.07.037

Cited by 14 publications

(4 citation statements)

References 38 publications

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“…Based on the obtained results and reported literature, [22,23] a possible mechanism for this MCR is exhibited in Scheme 3. The intermediate I is formed via the aldehyde protonating by H ＋ of β-CD-AIL.…”

Section: Figure 3 Reusability Of β-Cd-ail For the Synthesis Of 4amentioning

confidence: 71%

Synthesis of Tetrahydrobenzo[a]xanthen-11-ones Catalyzed byAcid Ionic Liquid Functionalized β-Cyclodextrin in Water

Liu¹,

Wang²,

Sun³

et al. 2019

Chinese Journal of Organic Chemistry

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Taking advantage of biocompatible β-cyclodextrin (β-CD) and ionic liquid (IL), β-cyclodextrin functionalized with acid ionic liquid (β-CD-AIL) was prepared and characterized by FT-IR, 1 H NMR and 13 C NMR. β-CD-AIL was evaluated as catalyst for the preparation of 12-aryl-8,9,10,12-tetrahydrobenzo [a]xanthen-11-ones via one-pot condensation reaction of β-naphthol, aromatic aldehydes and cyclic 1,3-dicarbonyl compounds. The results showed that β-CD-AIL behaved excellent efficiency and recyclability. The key benefits of this protocol involve mild reaction conditions, fast reaction speed, good to excellent yields and simple operational procedure.

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Section: Figure 3 Reusability Of β-Cd-ail For the Synthesis Of 4amentioning

confidence: 71%

Synthesis of Tetrahydrobenzo[a]xanthen-11-ones Catalyzed byAcid Ionic Liquid Functionalized β-Cyclodextrin in Water

Liu¹,

Wang²,

Sun³

et al. 2019

Chinese Journal of Organic Chemistry

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“…Our research interest is investigating the innovative catalysts for the construction of different biologically active heterocycles [44][45][46][47]. With this chemistry, we are mainly fascinating in producing a simpler method for the construction of multi-substituted pyridines by replacing toxic solvents and less toxic catalysts.…”

Section: Introductionmentioning

confidence: 99%

An eco‐efficient new path of mortar pestle grinding approach for the construction of methanol and ethylthio substituted pyridines with in silico studies

Edapu,

Boodida,

Pagadala

et al. 2023

Journal of Heterocyclic Chem

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A green and highly regioselective approach for the synthesis of poly‐substituted new pyridine derivatives via the Knoevenagel condensation followed by the Michael addition. The reaction involves intramolecular cyclization of easily obtainable reactants under environmentally and economically benign mortar pestle grinding technique. This method clearly proves that spatially hindered aldehydes also actively contribute to the construction of the desired pyridine derivatives with good yield (85%–96%) in about 30–40 min. This new avenue offers a number of benefits over earlier reaction approaches such as lengthy work‐up‐processes, operational difficulties and lower yields. This mortar pestle grinding technique is familiar for environmental and economical benign protocols. The druggability properties of synthesized compounds assessed using in silico studies.

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“…The principle of safe chemistry determines synthetic ways ought to be designed to use substances that exhibit very little or no toxicity to human health and atmosphere. The main aim to develop more capable synthetic protocols minimizes byproducts and in continuation of our recent interest using benzyltrimethylammonium dichloroiodate (BTADCI) catalyst in the construction of heterocyclic scaffolds . Hence, the possibility of performing multicomponent reactions for the production of pyrrole structure in solvent‐free conditions with BTADCI catalyst can boost their efficiency from an economic as well as a green point of view.…”

Section: Introductionmentioning

confidence: 99%

Benzyltrimethylammonium Dichloroiodate Catalyzed Four‐Component Synthesis of Fully Functionalized Pyrroles Under Eco‐compatible Conditions

Pagadala

Kusampally

2018

Journal of Heterocyclic Chem

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Metal free Lewis acid promoted one-pot synthesis of 14-aryl-14H dibenzo [a,j] xanthenes and their simple biological evolution

Cited by 14 publications

References 38 publications

Synthesis of Tetrahydrobenzo[a]xanthen-11-ones Catalyzed byAcid Ionic Liquid Functionalized β-Cyclodextrin in Water

Synthesis of Tetrahydrobenzo[a]xanthen-11-ones Catalyzed byAcid Ionic Liquid Functionalized β-Cyclodextrin in Water

An eco‐efficient new path of mortar pestle grinding approach for the construction of methanol and ethylthio substituted pyridines with in silico studies

Benzyltrimethylammonium Dichloroiodate Catalyzed Four‐Component Synthesis of Fully Functionalized Pyrroles Under Eco‐compatible Conditions

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