Metal nanoparticles as potent antimicrobial nanomachetes with an emphasis on nanogold and nanosilver

Borah, Sudarshana; Tripathy, Surendra; Bhuyan, Bitupan; Kaishap, Partha Pratim; Sharma, Hemanta Kumar; Choudhury, Gargi; Saikia, Lahari

doi:10.1016/b978-0-12-813667-6.00012-7

Cited by 3 publications

(6 citation statements)

References 93 publications

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“…Due to impending threats of MDR bacterial infections, a total of deaths per year were 23,000 in the USA, 25,000 in EU repetitively and 58,000 in India [17]. There are about 440,000 emerging MDR-TB cases per year, among them approximately 150,000 patients die each year all over the world [18] and it is estimated that about 10 million people may die every year by 2050 due to multidrug resistant (MDR) infections [15]. In the USA, nosocomial infections by the drug resistant pathogens cost thousands of lives and 125 billion $US extra hospital charges per year [19].…”

Section: Introductionmentioning

confidence: 99%

Silver Nanoparticles Synthesized by Using the Endophytic Bacterium Pantoea ananatis are Promising Antimicrobial Agents against Multidrug Resistant Bacteria

Rahman²,

et al. 2018

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Antibiotic resistance is one of the most important global problems currently confronting the world. Different biomedical applications of silver nanoparticles (AgNPs) have indicated them to be promising antimicrobial agents. In the present study, extracellular extract of an endophytic bacterium, Pantoea ananatis, was used for synthesis of AgNPs. The synthesized AgNPs were characterized by UV–Vis spectroscopy, FTIR, transmission electron microscopy (TEM), scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM-EDX), and Zeta potential. The antimicrobial potential of the AgNPs against pathogenic Staphylococcus aureus subsp. aureus (ATCC 11632), Bacillus cereus (ATCC 10876), Escherichia coli (ATCC 10536), Pseudomonas aeruginosa (ATCC 10145) and Candida albicans (ATCC 10231), and multidrug resistant (MDR) Streptococcus pneumoniae (ATCC 700677), Enterococcus faecium (ATCC 700221) Staphylococcus aureus (ATCC 33592) Escherichia coli (NCTC 13351) was investigated. The synthesized spherical-shaped AgNPs with a size range of 8.06 nm to 91.32 nm exhibited significant antimicrobial activity at 6 μg/disc concentration against Bacillus cereus (ATCC 10876) and Candida albicans (ATCC 10231) which were found to be resistant to conventional antibiotics. The synthesized AgNPs showed promising antibacterial efficiency at 10 µg/disc concentration against the MDR strains. The present study suggests that AgNPs synthesized by using the endophytic bacterium P. ananatis are promising antimicrobial agent.

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Section: Introductionmentioning

confidence: 99%

Silver Nanoparticles Synthesized by Using the Endophytic Bacterium Pantoea ananatis are Promising Antimicrobial Agents against Multidrug Resistant Bacteria

Rahman²,

et al. 2018

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“…Therefore, they are widely used as catalysts, nanowires, nanosensors, electron emitters, nanoprobes, and antibacterial, antifungal, and antiviral systems [ 87 , 91 , 92 , 94 ]. Additionally, since they are cheaper and involve low production costs, CuNPs are a potential competitor to AuNPs and AgNPs [ 87 , 91 , 92 , 95 , 96 ].…”

Section: Inorganic Nanoparticles With Antimicrobial Propertiesmentioning

confidence: 99%

“…Second, the Cu + ion from cuprous oxide (Cu 2 O) forms complexes with the peptides found within the microbial membranes [ 98 ]. Third, the dissociation of Cu 2+ from cupric oxide (CuO) induces ROS generation, leading to disturbances in amino acid and nucleic acid biosynthesis and the associated biochemical processes, e.g., iron displacement from iron–sulfur clusters and zinc or other metal ions competition for protein binding sites, disruption of the microbial membrane, and blocking of cellular respiration [ 60 , 95 , 96 , 98 , 99 ]. Additionally, it has been proven that CuNPs have a higher affinity towards amine and carboxyl groups onto the surface of the microbial cell [ 95 , 96 ].…”

Section: Inorganic Nanoparticles With Antimicrobial Propertiesmentioning

confidence: 99%

“…Third, the dissociation of Cu 2+ from cupric oxide (CuO) induces ROS generation, leading to disturbances in amino acid and nucleic acid biosynthesis and the associated biochemical processes, e.g., iron displacement from iron–sulfur clusters and zinc or other metal ions competition for protein binding sites, disruption of the microbial membrane, and blocking of cellular respiration [ 60 , 95 , 96 , 98 , 99 ]. Additionally, it has been proven that CuNPs have a higher affinity towards amine and carboxyl groups onto the surface of the microbial cell [ 95 , 96 ]. Thus, they exhibit higher antimicrobial activities against B. subtilis and E. coli and silver-resistant species, such as M. morganii and M. psychrotolerans [ 86 , 95 , 96 , 97 , 98 ].…”

Section: Inorganic Nanoparticles With Antimicrobial Propertiesmentioning

confidence: 99%

“…Additionally, it has been proven that CuNPs have a higher affinity towards amine and carboxyl groups onto the surface of the microbial cell [ 95 , 96 ]. Thus, they exhibit higher antimicrobial activities against B. subtilis and E. coli and silver-resistant species, such as M. morganii and M. psychrotolerans [ 86 , 95 , 96 , 97 , 98 ]. Furthermore, owing to their large surface-to-volume ratio, CuNPs have proven effective against plant pathogenic fungi, such as F. oxysporum , C. lunata , A. alternata , and P. destructive [ 98 ].…”

Section: Inorganic Nanoparticles With Antimicrobial Propertiesmentioning

confidence: 99%

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Inorganic Nanoparticles and Composite Films for Antimicrobial Therapies

Spirescu

Chircov

Grumezescu

et al. 2021

IJMS

107

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The development of drug-resistant microorganisms has become a critical issue for modern medicine and drug discovery and development with severe socio-economic and ecological implications. Since standard and conventional treatment options are generally inefficient, leading to infection persistence and spreading, novel strategies are fundamentally necessary in order to avoid serious global health problems. In this regard, both metal and metal oxide nanoparticles (NPs) demonstrated increased effectiveness as nanobiocides due to intrinsic antimicrobial properties and as nanocarriers for antimicrobial drugs. Among them, gold, silver, copper, zinc oxide, titanium oxide, magnesium oxide, and iron oxide NPs are the most preferred, owing to their proven antimicrobial mechanisms and bio/cytocompatibility. Furthermore, inorganic NPs can be incorporated or attached to organic/inorganic films, thus broadening their application within implant or catheter coatings and wound dressings. In this context, this paper aims to provide an up-to-date overview of the most recent studies investigating inorganic NPs and their integration into composite films designed for antimicrobial therapies.

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Polymer-Stabilized Silver (Gold)–Zinc Oxide Nanoheterodimer Structures as Antimicrobials

Samoilova,

Krayukhina,

Naumkin

et al. 2023

Applied Sciences

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A simple one-pot method is proposed for obtaining the colloidal nanohybrid structures of silver (gold) and zinc oxide as well as nanostructures doped with zinc ions. The copolymers of maleic acid were used for the stabilization of nanoheterostructures. To characterize the preparation, UV–Vis spectroscopy, TEM, FTIR, XPS, and XRD were used. The bactericidal properties of the nanoheterostructures were studied in relation to the fungus C. albicans and the bacteria E. coli and S. aureus, used in planktonic form. In general, the samples containing nanosilver were the most active, and the preparations containing gold nanoparticles were the least active. The minimum inhibitory concentrations (MICs) of the Ag/ZnO samples, based on all copolymers, were in the ranges of 1.4–1.7 μg/mL for C. albicans, 2.9–6.8 μg/mL for E. coli, and 23–27 μg/mL for S. aureus; the MIC values of Au/ZnO samples were 472 μg/mL for S. aureus and 945 μg/mL for C. albicans and E. coli. The additional introduction of zinc cations into heterodimers had practically no effect on the antimicrobial properties of the composites. For all prepared composites and all tested microorganisms, the fractional inhibitory concentration indexes were in the range of 0.5–2.2, which indicates a close-to-additive contribution of the bioactive components in the samples used in the bactericidal process.

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Metal nanoparticles as potent antimicrobial nanomachetes with an emphasis on nanogold and nanosilver

Cited by 3 publications

References 93 publications

Silver Nanoparticles Synthesized by Using the Endophytic Bacterium Pantoea ananatis are Promising Antimicrobial Agents against Multidrug Resistant Bacteria

Silver Nanoparticles Synthesized by Using the Endophytic Bacterium Pantoea ananatis are Promising Antimicrobial Agents against Multidrug Resistant Bacteria

Inorganic Nanoparticles and Composite Films for Antimicrobial Therapies

Polymer-Stabilized Silver (Gold)–Zinc Oxide Nanoheterodimer Structures as Antimicrobials

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