Metal–Organic Framework Nanospheres with Well‐Ordered Mesopores Synthesized in an Ionic Liquid/CO<sub>2</sub>/Surfactant System

Zhao, Yang; Zhang, Jianling; Han, Buxing; Song, Jinliang; Li, Jianshen; Wang, Qian

doi:10.1002/anie.201005314

Cited by 290 publications

(143 citation statements)

References 77 publications

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“…96 MOFs consist of transition metal ions/clusters and multidentate organic ligands, and are typically synthesized via coordinationdirected self-assembly processes under mild conditions ( Figure 4). 97 Over the past two decades, MOFs have been applied in photonics, 98 catalysis, [99][100][101] biosensors, 102,103 gas storage, [104][105][106][107] and drug delivery. [108][109][110][111] For drug delivery, the high drug-loading capacity of MOFs relies largely on three factors: 1) high surface area (3,100-5,900 m 2 /g) 108 and large, regular, accessible cages and tunnels; 2) good physicochemical stability in circulation and quick stimuli 109,113 -effectively in hexane solution.…”

Section: Absorption/desorption-type Mofs As Carriersmentioning

confidence: 99%

High drug-loading nanomedicines: progress, current status, and prospects

Shen

Liu

et al. 2017

IJN

438

268

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Drug molecules transformed into nanoparticles or endowed with nanostructures with or without the aid of carrier materials are referred to as “nanomedicines” and can overcome some inherent drawbacks of free drugs, such as poor water solubility, high drug dosage, and short drug half-life in vivo. However, most of the existing nanomedicines possess the drawback of low drug-loading (generally less than 10%) associated with more carrier materials. For intravenous administration, the extensive use of carrier materials might cause systemic toxicity and impose an extra burden of degradation, metabolism, and excretion of the materials for patients. Therefore, on the premise of guaranteeing therapeutic effect and function, reducing or avoiding the use of carrier materials is a promising alternative approach to solve these problems. Recently, high drug-loading nanomedicines, which have a drug-loading content higher than 10%, are attracting increasing interest. According to the fabrication strategies of nanomedicines, high drug-loading nanomedicines are divided into four main classes: nanomedicines with inert porous material as carrier, nanomedicines with drug as part of carrier, carrier-free nanomedicines, and nanomedicines following niche and complex strategies. To date, most of the existing high drug-loading nanomedicines belong to the first class, and few research studies have focused on other classes. In this review, we investigate the research status of high drug-loading nanomedicines and discuss the features of their fabrication strategies and optimum proposal in detail. We also point out deficiencies and developing direction of high drug-loading nanomedicines. We envision that high drug-loading nanomedicines will occupy an important position in the field of drug-delivery systems, and hope that novel perspectives will be proposed for the development of high drug-loading nanomedicines.

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Section: Absorption/desorption-type Mofs As Carriersmentioning

confidence: 99%

High drug-loading nanomedicines: progress, current status, and prospects

Shen

Liu

et al. 2017

IJN

438

268

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“…ICPs can be either highly crystalline structures, known as metal-organic frameworks (MOFs) (Oh, & Mirkin, 2005;Zhao et al, 2011) or amorphous nano/micro particles (Jeon, Armatas, Heo, Kanatzidis, & Mirkin, 2008). Metal ions in ICPs bridged with organic ligands establish coupling between conduction electrons (π electrons) and localized magnetic moments (d spins) through π-d interaction.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Electronic and Optical Properties of Cobalt(II) Dithiocarbamate Fluorescent Nanowires for Optoelectronic Devices

Ujjain¹,

Ahuja²,

Sharma³

et al. 2015

IJC

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Schiff base containing symmetric bis-dithiocarbamate ligand Na 2 [dtc-SB-dtc] (SB = Bi-Schiff base Phenylene diamine) is synthesized and metallated with Co(II)Cl 2 .6H 2 O to form [Co(dtc-SB-dtc).2H 2 O] n Co(dtc-SB) infinite coordination polymer (ICP) nanowires [Co(dtc-SB) NWs]. Pair of Satellites in X-ray photoelectron spectroscopy (XPS) spectrum of Co 2p confirm the formation of hexa-coordinated Co(II). Presence of hyperfine pattern in low temperature EPR spectrum is due to the splitting of octahedral ground state 4 T 1 for Co(II). Introduction of a rigid, non-planar, four membered dtc Cobalt chelating ring in coordination polymer assisted in reduction of photoinduced electron transfer (PET) process to yield high fluorescence. Prepared Co(dtc-SB) NWs are highly resistive however after suitable doping, exhibit p and n type conductivity. Temperature dependent conductivity results of different doping concentrations in NWs reflect activated type conduction with two different activation energies. UV-Visible absorption spectra show decrement in optical gap whereas emission spectra demonstrate quenching after p and n doping. Efficient quenching of emission indicates energy transfer between dopant ions and NWs.

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“…Ordered mesoporous MOF nanospheres reminiscent of the mesoporous silica nps advanced as potential drug delivery systems 176 have recently been prepared using a ternary ionic liquid/scCO 2 /surfactant reaction system. 177 ( Fig. 56) Fig.…”

Section: Mofs At Liquid Crystal Interfacesmentioning

confidence: 99%

Metal–organic framework growth at functional interfaces: thin films and composites for diverse applications

2012

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5Porous metal-organic frameworks (MOFs) are highly ordered crystalline materials prepared by the selfassembly of metal ions with organic linkers to yield low density network structures of diverse topology. MOFs have attracted considerable attention over the last decade due to their facile preparation, tunable pore metrics and the ease of functionalisation of their internal surfaces, such that designer frameworks with exceptional properties for application in gas-storage, separation of small molecules, heterogeneous 10 catalysis and drug delivery are becoming commonplace. For any material to find practical utility however there is a need for processing and formulation into application-specific configurations. One way to do this is to prepare composite materials where the MOF is supported on a planar substrate or some other shaped body through interaction with functional groups at the support interface. This is a rapidly developing research area, and this review provides an overview of the diverse MOF composite materials prepared up 15 to now, organised by interface type. The importance of the interface is explored within each section and while the overall emphasis is on applications of the composites, coatings and MOF-based devices, the most widely-used and successful synthetic strategies for composite formation are also presented. (183 references)

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Metal–Organic Framework Nanospheres with Well‐Ordered Mesopores Synthesized in an Ionic Liquid/CO₂/Surfactant System

Cited by 290 publications

References 77 publications

High drug-loading nanomedicines: progress, current status, and prospects

High drug-loading nanomedicines: progress, current status, and prospects

Synthesis, Electronic and Optical Properties of Cobalt(II) Dithiocarbamate Fluorescent Nanowires for Optoelectronic Devices

Metal–organic framework growth at functional interfaces: thin films and composites for diverse applications

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Metal–Organic Framework Nanospheres with Well‐Ordered Mesopores Synthesized in an Ionic Liquid/CO2/Surfactant System

Cited by 290 publications

References 77 publications

High drug-loading nanomedicines: progress, current status, and prospects

High drug-loading nanomedicines: progress, current status, and prospects

Synthesis, Electronic and Optical Properties of Cobalt(II) Dithiocarbamate Fluorescent Nanowires for Optoelectronic Devices

Metal–organic framework growth at functional interfaces: thin films and composites for diverse applications

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Metal–Organic Framework Nanospheres with Well‐Ordered Mesopores Synthesized in an Ionic Liquid/CO₂/Surfactant System