Metal–organic framework templated synthesis of Co3O4 nanoparticles for direct glucose and H2O2 detection

Abstract

Co(3)O(4) nanoparticles (NPs) with an average diameter of about 20 nm were synthesized by using MOFs as a template. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) were employed to characterize the as-prepared Co(3)O(4) NPs. Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) were used to confirm the structure of the Co(3)O(4) NPs. Then the Co(3)O(4) NPs were modified on a glassy carbon electrode (GCE) to obtain a non-enzymatic glucose and H(2)O(2) sensor. The NPs show electrocatalytic activity toward oxidation of glucose and H(2)O(2) in alkaline medium. For glucose detection, the developed sensor shows a short response time (less than 6 s), a high sensitivity of 520.7 μA mM(-1) cm(-2), a detection limit of 0.13 μM (S/N = 3), and good selectivity. The high concentration of NaCl does not poison the electrode. Its application for the detection of glucose in a human blood serum sample shows good agreement with the results obtained from the hospital. Furthermore, the proposed sensor was used for the detection of H(2)O(2). The results indicate that the detection limit and sensitivity for H(2)O(2) are 0.81 μM and 107.4 μA mM(-1) cm(-2), respectively. Determination of H(2)O(2) concentration in a disinfectant sample by the proposed biosensor also showed satisfactory result. The high sensitivity and low detection limit can be attributed to the excellent electrocatalytic performance of the as-prepared Co(3)O(4) NPs. These results demonstrate that the as-prepared Co(3)O(4) NPs have great potential applications in the development of sensors for enzyme-free detection of glucose and H(2)O(2).

Fast Synthesis of Hierarchical Co(OH)2 Nanosheet Hollow Spheres with Enhanced Glucose Sensing

“…[12] The applicability of the glucose biosensor was assessed by determining the glucose concentration in human blood serum samples. Diluted human blood serum sample was added into 0.1 M NaOH, and the current response was recorded at 0.53 V. The glucose concentration in human blood serum sample was determined to be 4.71 mM with a RSD of 7 %, in [14] PSAC/CO 3 O 4 34.23 0.02 22 [15] Cobalt oxide nanorods 571.8 0.058 3.5 [16] Co/CoOOH 967 10.9 0.5 [17] Co 3 O 4 nanoparticles 520.7 0.13 0.8 [18] CoOOH nanosheet 526.8 1.37 1.109 [19] Co 3 O 4 /Nafion/GCE 36.25 0.97 2.04 [20] Co(OH) 2 comparison to a concentration of 4.4 mM that is determined in hospital.…”

Highly sensitive H2O2 sensor based on Co3O4 hollow sphere prepared via a template-free method

“…The redox peak currents increased linearly with the scan rate in the range from 25 to 200 mV/s (Fig. 3B), suggesting a surface-controlled electrochemical process [28]. For the Co 3 O 4 modified electrode, two pairs of well-defined redox peaks were 13 obtained.…”

Facile synthesis of ultrafine Co3O4 nanocrystals embedded carbon matrices with specific skeletal structures as efficient non-enzymatic glucose sensors

“…In order to prepared the nanoscale semiconducting metal oxide with various morphologies (such as nanocubes, nanotubes, nanofibers, nanoplates, etc. ), various synthesis strategies have been adopted such as vapor phase transport method [22], electrospinning [21], template-assisted processes [23,24], solvothermal synthesis [25,26], sol-gel method [27], and lithography technique [28]. However, these strategies generally require high reaction temperature, complex technologies, expensive equipments, and harmful organic reagents or surfactants, which might further hinder their application.…”