Metal-organic frameworks for on-demand pH controlled delivery of vancomycin from chitosan scaffolds

Karakeçili, Ayşe; Topuz, Berna; Korpayev, Serdar; Erdek, Mert

doi:10.1016/j.msec.2019.110098

Cited by 91 publications

(57 citation statements)

References 36 publications

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“…[ 30–35 ] Researches in understanding the biological effect of ZIF‐8 in bone tissue engineering have focused on drug delivery of therapeutic agents in hosts for bone‐related disease treatment and surface modification of orthopedic implants. [ 36–40 ] To date, our recent efforts on ZIF‐8 have led to nanoscale ZIF‐8 crystals on porous titanium with a crystal size of 200–300 nm that is endowed with excellent cytocompatibility, osteogenic activity, and biodegradability. As Zn 2+ ions were slowly released from the titanium surface without a burst‐release effect, ZIF‐8 crystals could be gradually degraded under biological conditions.…”

Section: Introductionmentioning

confidence: 99%

Accelerated Bone Regeneration by MOF Modified Multifunctional Membranes through Enhancement of Osteogenic and Angiogenic Performance

Xue

Zhu

Zhang

et al. 2021

Adv Healthcare Materials

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Owing to the insufficient guidance of new bone formation in orthopedic and craniomaxillofacial surgery, construction of a guided bone regeneration membrane to support vascularized bone regeneration remains a challenge. Herein, an electrospun asymmetric double‐layer polycaprolactone/collagen (PCL/Col) membrane modified by metal–organic framework (MOF) crystals is developed. The optimization of the PCL/Col weight ratio (1:1 and 1:1.5) enables the composite membrane with a balanced tensile strength (only fell by 49.9% in wet conditions) and a controlled degradation rate (completely degraded at 12 weeks). The MOF crystals can provide a pH‐responsive release of Zn2+ ions. In vitro experiments indicate that the barrier layer functions to prevent the infiltration of fibrous connective tissue. The MOF crystal layer functions to enhance osteogenesis and angiogenesis in vitro. Using a rat calvarial defect model, the MOF crystals exhibit a sign of osteoinductivity along with blood vessel formation after 8 weeks post‐surgery. Strikingly, when assessed in a chick chorioallantoic membrane model, the MOF modified membrane demonstrates a significant angiogenic response, which can be envisaged as its outstanding merits over the commercially Col membrane. Therefore, the MOF crystals represent an exciting biomaterial option, with neovascularization capacity for bone tissue engineering and regenerative medicine.

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Section: Introductionmentioning

confidence: 99%

Accelerated Bone Regeneration by MOF Modified Multifunctional Membranes through Enhancement of Osteogenic and Angiogenic Performance

Xue

Zhu

Zhang

et al. 2021

Adv Healthcare Materials

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“…20,21 Indeed, the potential of MOFs to act as reservoirs and delivery systems for antimicrobial agents to help address the problems of infection and bacterial resistance is now receiving much attention. For example, MOFs can be employed as delivery agents for antimicrobial metal ions such as Zn, Cu and Ag with improved efficiency; 22,23 they offer controlled and potentially more targeted delivery of antibiotics and antiseptics (for example, ciprofloxacin, 24 ceftazidime, 25 vancomycin, 26 metronidazole, 27 rifampicin 28 and tinidazole 29 ); and they can offer combination treatments by delivering multiple agents simultaneously or over different time scales. 30,31 Some reports suggest synergistic effects can be achieved through careful selection of metal ion and antibiotic to heighten drug potency.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial efficacy from NO-releasing MOF–polymer films

et al. 2020

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“…MC3T3-E1 response when cultured on scaffolds of pure chitosan (CHI, used as control) and chitosan with 5% of Van@ZIF-8,bothplain (CHI-5 %-ZIF8) and reinforced( CHI-5 %-ZIF8-CL): (a) proliferation, (b) ALP activity and (c) calciumd eposition. Reproducedw ith permission from reference [25].C opyright 2019, Elsevier. structural arrangements or particlesize show distinct biological properties.…”

Section: Discussionmentioning

confidence: 99%

“…Reinforced scaffolds with crosslinked glyoxal were also prepared (by treating the scaffolds with a1m m glyoxal ethanol solution). [25] The vancomycin load was released from the scaffolds in ap H-dependent fashion,w ith 70 %b eing released during 48 ha tp H5.4, and only 55 %a tp H7.4. Proliferative evaluation studies showedt hat cells of the MC3T3-E1 pre-osteoblast line continued to proliferate on all scaffolds during 21 days of culture ( Figure 15).…”

Section: Hybrids With Polymer Scaffoldsmentioning

confidence: 97%

Bone Tissue Disorders: Healing Through Coordination Chemistry

Barbosa

Mendes

Figueira

et al. 2020

Chemistry A European J

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Osteoporosis, Paget's disease and osteosarcoma are a few examples of bone tissue disorders that affect millions of people worldwide. These conditions can strictly limit the lifestyle of patients and may even lead to their demise. To prevent this or, at least, try to manage the situation, there are several treatments available on the market. Notwithstanding, research has been driven by the possibility to improve the existing therapies, as well as to find new approaches that could better respond to these diseases. In this Review the path is shown through which, in recent years, coordination compounds have been prepared and manufactured to be applied in the management of bone tissue disorders. Starting with the design and preparation of the coordination compounds with various dimensionalities, two approaches have been used: (1) they are prepared as three‐dimensional cages that can act as delivery systems for therapeutic substances, or (2) they are constructed/prepared from compounds with intrinsic therapeutic properties. Following this, several strategies have been explored to manufacture the effective delivery to the patients. The versatility of coordination compounds has allowed their use in the preparation of drug tablets, coatings for titanium implants, or even scaffolds for bone tissue engineering. In the end, it becomes clear that these compounds can be a valuable approach to reach a better treatment for bone tissue disorders. Nonetheless, along the road, a few bumps have appeared concerning the therapeutic profile, such as the effect of the structural arrangement or particle size.

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Metal-organic frameworks for on-demand pH controlled delivery of vancomycin from chitosan scaffolds

Cited by 91 publications

References 36 publications

Accelerated Bone Regeneration by MOF Modified Multifunctional Membranes through Enhancement of Osteogenic and Angiogenic Performance

Accelerated Bone Regeneration by MOF Modified Multifunctional Membranes through Enhancement of Osteogenic and Angiogenic Performance

Antibacterial efficacy from NO-releasing MOF–polymer films

Bone Tissue Disorders: Healing Through Coordination Chemistry

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