Metal organic frameworks (MOFs) with therapeutic and biomedical applications: a patent review

Filho, José Marcos Teixeira de Alencar; Sampaio, Pedrita Alves; Carvalho, Iure Silva de; Silva, Ademar Rocha da; Pereira, Emanuella Chiara Valença; Amariz, Isabela Araujo e; Nishimura, Rodolfo Hideki Vicente; Araújo, Edigênia Cavalcante da Cruz; Rolim-Neto, Pedro José; Rolim, Larissa Araújo

doi:10.1080/13543776.2021.1924149

Cited by 12 publications

(3 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Metal–organic frameworks are a class of porous crystal materials with ordered network structures formed by the chelation of metal ions or metal clusters with organic ligands. , It has lots of unique advantages such as diverse structure, adjustable pore size, large specific surface area, easy functionalization, and good thermal stability. , The large specific surface area and flexible adjustment of pore structure of MOFs provide high adsorption capacity and more active binding sites . Functionalization can be easily achieved through presynthesis or postsynthesis methods to meet different practical demands, so MOFs play an important role in the separation field. , Currently, MOFs are mainly used to assist laser desorption/ionization in MSI applications due to its good UV absorption capability and low background peaks in LDI-MS. − However, other applications of MOFs to MSI utilizing their excellent chemical adsorptive properties are still lacking.…”

Section: Introductionmentioning

confidence: 99%

Lewis Acidic Metal–Organic Framework Assisted Ambient Liquid Extraction Mass Spectrometry Imaging for Enhancing the Coverage of Poorly Ionizable Lipids in Brain Tissue

Lv,

Zhao,

Long

et al. 2024

Anal. Chem.

View full text Add to dashboard Cite

The spatial distribution of lipidomes in tissues is of great importance in studies of living processes, diseases, and therapies. Mass spectrometry imaging (MSI) has become a critical technique for spatial lipidomics. However, MSI of low-abundance or poorly ionizable lipids is still challenging because of the ion suppression from highabundance lipids. Here, a metal−organic framework (MOF) Zr 6 O 4 (OH) 4 (1,3,5-Tris(4carboxyphenyl) benzene) 2 (triflate) 6 (Zr 6 OTf-BTB) was prepared and used for selective on-tissue adsorption of phospholipids to reduce ion suppression from them to poorly ionizable lipids. The results show that Zr 6 OTf-BTB with strong Lewis acidic sites and a large specific surface area (647.9 m 2 •g −1 ) could selectively adsorb phospholipids under 1% FA-MeOH. Adsorption efficiencies of phospholipids are 88.4−144.9 times higher than those of other neutral lipids. Moreover, the adsorption capacity and the adsorption kinetic rate constant of the new material to phospholipids are higher than those of Zr 6 -BTB (242.72 vs 73.96 mg•g −1 , 0.0442 vs 0.0220 g•mg −1 •min −1 ). A Zr 6 OTf-BTB sheet was prepared by a lamination technique for on-tissue phospholipid adsorption from brain tissue. Then, the tissue section on the Zr 6 OTf-BTB sheet was directly imaged via ambient liquid extraction-MSI with 1% FA-MeOH as the sampling solvent. The results showed that phospholipids could be 100% removed directly on tissue, and the detection coverage of the Zr 6 OTf-BTB-enhanced MSI method to ceramides (Cers) and hexosylceramides (HexCers) was increased by 5−26 times compared with direct tissue MSI (26 vs 1 and 17 vs 3). The new method provides an efficient and convenient way to eliminate the ion suppression from phospholipids in MSI, largely improving the detection coverage of low-abundance and poorly ionizable lipids.

show abstract

Section: Introductionmentioning

confidence: 99%

Lewis Acidic Metal–Organic Framework Assisted Ambient Liquid Extraction Mass Spectrometry Imaging for Enhancing the Coverage of Poorly Ionizable Lipids in Brain Tissue

Lv,

Zhao,

Long

et al. 2024

Anal. Chem.

View full text Add to dashboard Cite

show abstract

“…Nanotechnology and metal-organic frameworks (MOFs) have found a worthy place in medical science ( Bieniek et al, 2021 ; de Alencar Filho et al, 2021 ). In MOFs, which are composed of ligands and metals, the most important roles of ligands are flexibility and the possibility of controlling the size and environment of the holes ( Cai et al, 2021 ; Shen et al, 2021 ; Kumar et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Microwave-assisted synthesis of novel Ti/BTB-MOFs as porous anticancer and antibacterial agents

Altharawi,

Alqahtani,

Aldakhil

et al. 2024

Front. Chem.

View full text Add to dashboard Cite

Nano compounds, especially metal-organic frameworks (MOFs), have significant properties. Among the most important properties of these compounds, which depend on their specific surface area and porosity, are biological properties, such as anticancer and antibacterial properties. In this study, a new titanium/BTB metal-organic framework (Ti/BTB-MOF) was synthesized by using titanium nitrate and 1,3,5-Tris(4-carboxyphenyl)benzene (BTB) under microwave radiation. The structure of the synthesized Ti/BTB-MOF was characterized and confirmed using X-ray diffraction (XRD) patterns, X-ray photoelectron spectroscopy (XPS) analysis, Fourier transform infrared (FT-IR) spectra, energy-dispersive X-ray (EDAX) analysis mapping, scanning electron microscope (SEM) images, thermogravimetric analysis (TGA) curves, and Brunauer–Emmett–Teller (BET) analysis. The in vitro anticancer properties of Ti/BTB-MOF were evaluated using the MTT method against MG-63/bone cancer cells and A-431/skin cancer cells. The in vitro antibacterial activity was tested using the Clinical and Laboratory Standards Institute (CLSI) guidelines. In the anticancer activity, IC50 (half-maximal inhibitory concentration) values of 152 μg/mL and 201 μg/mL for MG-63/bone cancer cells and A-431/skin cancer cells, respectively, were observed. In the antibacterial activity, minimum inhibitory concentrations (MICs) of 2–64 μg/mL were observed against studied pathogenic strains. The antimicrobial activity of Ti/BTB-MOF was higher than that of penicillin and gentamicin. Therefore, the synthesized Ti/BTB-MOF could be introduced as a suitable bioactive candidate.

show abstract

“…Also, MOFs are highly attractive due to their unique characteristics, such as large pore sizes, remarkable surface areas, and giant pore volumes (2)(3)(4)(5). In recent years, MOFs have emerged in the biomedical field (6)(7)(8)(9)(10)(11)(12), especially as drug carriers for treating tumors (13)(14)(15). For instance, Ni et al reported two Hf-based MOFs, designed as carriers for combined checkpoint blockade immunotherapy and radiotherapy, showing high antitumor ability against CT26-induced colorectal cancer model in mice (16).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of a Novel Zinc-Based Metal-Organic Framework Containing Benzoic Acid: A Low-Toxicity Carrier for Drug Delivery

Xiong

Yuan

et al. 2023

Iran J Pharm Res

View full text Add to dashboard Cite

: In recent years, metal-organic frameworks (MOFs) have gained attention in the biomedical field, particularly as drug carriers for treating tumors. Therefore, we decided to synthesize a novel benzoic acid Zn-based MOF and study the Zn-based MOFs' drug-delivery properties and the drug-delivery system's anticancer effects. This study successfully synthesized a zinc-based MOF using solvent thermal synthesis. The crystal structure of a Zn-based MOF was investigated using thermogravimetric analysis, X-ray diffraction, and Fourier transform infrared spectroscopy. Subsequently, the results of UV spectrophotometry showed that Doxorubicin was successfully loaded with a loading amount of 33.74%. Furthermore, the drug release experiments demonstrated that the Zn-based MOF was pH-sensitive, releasing more at a pH of 3.8 than at pH 5.8 or 7.4. Finally, the Zn-based MOF loaded with drugs exhibited high antitumor activity against HepG2 cells while demonstrating remarkably low toxicity to normal cells (LO2). Taken together, these results demonstrate that the Zn-based MOF has the potential to serve as a carrier in the field of drug delivery systems.

show abstract

Metal organic frameworks (MOFs) with therapeutic and biomedical applications: a patent review

Cited by 12 publications

References 58 publications

Lewis Acidic Metal–Organic Framework Assisted Ambient Liquid Extraction Mass Spectrometry Imaging for Enhancing the Coverage of Poorly Ionizable Lipids in Brain Tissue

Lewis Acidic Metal–Organic Framework Assisted Ambient Liquid Extraction Mass Spectrometry Imaging for Enhancing the Coverage of Poorly Ionizable Lipids in Brain Tissue

Microwave-assisted synthesis of novel Ti/BTB-MOFs as porous anticancer and antibacterial agents

Synthesis and Characterization of a Novel Zinc-Based Metal-Organic Framework Containing Benzoic Acid: A Low-Toxicity Carrier for Drug Delivery

Contact Info

Product

Resources

About