Metal Sulfide Nanoparticles for Imaging and Phototherapeutic Applications

Abstract

The intriguing properties of metal sulfide nanoparticles (=MxSy-NPs), particularly transition metal dichalcogenides, are discussed for their use in diverse biological applications. Herein, recent advances in MxSy-NPs-based imaging (MRI, CT, optical and photoacoustic) and phototherapy (photothermal and photodynamic) are presented. Also, recent made progress in the use of immuno-phototherapy combinatorial approaches in vitro and in vivo are reported. Furthermore, challenges in nanomaterials-based therapies and future research directions by applying MxSy-NPs in combinatorial therapies are envisaged.

In situ copper-ion catalyzed synthesis of copper containing poly(isocyanurate-urea) xerogels with antibacterial activity and biocompatibility for biomedical applications

“…This redox activity can potentially damage bacteria and generate highly reactive hydroxyl radicals and other reactive oxygen species. 64,65 These radicals can cause detrimental reactions, including destabilization of the cell wall and oxidation of proteins and lipids, thereby contributing to the antibacterial effect. 66 Furthermore, copper ions can disrupt bacterial cell function by replacing and/or binding with native cofactors in metalloproteins.…”

Paclitaxel-Loaded PLGA/Au Nanocylinders for the Photothermal-Chemotherapy Treatment of Cancer

“…In recent years, metal sulfides, organic small molecule-based photothermal agents − (porphyrins, phthalocyanines, and borodipyrrole) and organic polymers (polypyrrole and polydopamine) have been used as photothermal agents. , Photothermal agents, drugs, and nanocarriers were usually combined to prepare NIR-triggered nanodrug delivery systems by using traditional chemical methods − (nanoprecipitation, self-assembly, emulsion solvent evaporation technique, etc. ), which displayed low-cost.…”

“…9,10 In order to further improve the therapeutic effect of tumors, one of the current research directions is devoted to develop a nanotherapeutic system with both chemotherapy and photothermal treatment. 11,12 In recent years, metal sulfides, 13 organic small moleculebased photothermal agents 14−16 (porphyrins, phthalocyanines, and borodipyrrole) and organic polymers (polypyrrole and polydopamine) have been used as photothermal agents. 17,18 Photothermal agents, drugs, and nanocarriers were usually combined to prepare NIR-triggered nanodrug delivery systems by using traditional chemical methods 19−21 (nanoprecipitation, self-assembly, emulsion solvent evaporation technique, etc.…”