Metal Toxicology

Martinez-Finley, Ebany J.; Caito, Sam; Fretham, Stephanie J. B.; Chen, Pan; Aschner, Michael

doi:10.1002/9781118683484.ch8

Cited by 1 publication

(1 citation statement)

References 51 publications

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“…[81] Manganese exerts its function by participating in the modulation of numerous metalloenzymes or metalloproteins, such as glutamine synthetase (GS), manganese superoxide dismutase (Mn-SOD), lectins, and integrins. [82] For the maintenance of normal metabolism in the body, cellular manganese homeostasis is grimly regulated by its uptake, distribution, storage, and efflux. There is already evidence that the disturbance of manganese homeostasis is involved in oncogenesis.…”

Section: Modulation Of Manganese Homeostasis For Cancer Therapymentioning

confidence: 99%

Modulation of Metal Homeostasis for Cancer Therapy

Yang,

Fan,

Guo

2024

ChemPlusChem

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Metal ions such as iron, zinc, copper, manganese, and calcium are essential for normal cellular processes, including DNA synthesis, enzyme activity, cellular signaling, and oxidative stress regulation. When the balance of metal homeostasis is disrupted, it can lead to various pathological conditions, including cancer. Thus, understanding the role of metal homeostasis in cancer has led to the development of anti‐tumor strategies that specifically target the metal imbalance. Up to now, diverse small molecule‐based chelators, ionophores, metal complexes, and metal‐based nanomaterials have been developed to restore the normal balance of metals or exploit the dysregulation for therapeutic purposes. They hold great promise in inhibiting tumor growth, preventing metastasis, and enhancing the effectiveness of existing cancer therapies. In this review, we aim to provide a comprehensive summary of the strategies employed to modulate the homeostasis of iron, zinc, copper, manganese, and calcium for cancer therapy. Their modulation mechanisms for metal homeostasis are succinctly described, and their recent applications in the field of cancer therapy are discussed. At the end, the limitations of these approaches are addressed, and potential avenues for future developments are explored.

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Section: Modulation Of Manganese Homeostasis For Cancer Therapymentioning

confidence: 99%