Metallkomplexe mit biologisch wichtigen Liganden, CXXIV [1]. NMR-spektroskopische Bestimmung des Enantiomerenverhältnisses von α-Aminosäuren mit Hilfe eines chiralen orthometallierten Palladiumkomplexes/Metal Complexes of Biologically Important Ligands, CXXIV [1]. NMR-Spectroscopic Determination of the Enantiomeric Ratio of α-Amino Acidsby Use of a Chiral Orthometallated Palladium Complex

Abstract

The chiral orthometallated palladium complex (S)-[Pd{C6H4 (CH(CH3)N(CH3)2 )-C,N}Cl]2 (1) can be used as a reagent for the determination of the enantiomeric ratio of α-amino acids. By reaction of 1 with mixtures of several D- and L-α-amino carboxylates diastereoisomers of the α-amino acidato complexes 2a - g are obtained. 1NMR determination of the ratio of the diastereoisomers provides the D/L-ratio of the used D- and L-α-amino carboxylates and is therefore a simple method for the determination of the enantiomeric ratio of α-amino acids.