Metallothionein polymorphisms in a Northern Spanish population with neovascular and dry forms of age-related macular degeneration

Abstract

The present study is the first to investigate the potential association of SNPs at MT genes with susceptibility to AMD. We found a significant association of SNP rs28366003 at MT2A gene with susceptibility to the dry form of AMD in a Northern Spanish population.

Association of the polymorphism Y402H in the CFH gene with response to anti‐VEGF treatment in age‐related macular degeneration: a systematic review and meta‐analysis

“…; García et al. ). In addition, numerous studies have revealed that this variant might influence treatment outcomes in patients with AMD (Dedania et al.…”

Evaluation of CC‐cytokine ligand 2 and complementary factor H Y402H polymorphisms and their interactional association with age‐related macular degeneration

“…This action may be restricted if the polymorphism in the CFH gene changes the protein product while uncontrolled action of complement cascades is able to recruit inflammatory cells towards retina. Several studies have shown association of CFH gene especially Y402H variants with AMD in most ethnicities (Edwards et al 2005;Haines et al 2005;Klein et al 2005;Chowers et al 2008; Nischler et al 2011;Quan et al 2012;Soysal et al 2012;Garc ıa et al 2015;Hautam€ aki et al 2015;Hughes et al 2015). However, in some other ethnicities such as Koreans, CFH Y402H polymorphism was only shown to be marginally associated with the risk of developing AMD (Kim et al 2008).…”

Metallothionein 2A gene polymorphisms in relation to diseases and trace element levels in humans

“…We conducted the first study of that kind in Croatia and found that nearly 6 % of the healthy postpartum women were G allele carriers ( 4 ). Several authors reported higher percentages of G allele carriers in case study groups than controls ( 80 , 84 , 97 , 100 ), and others reported no differences ( 88 , 96 ). Higher frequency of AG genotype was reported among white (12.8 %) than black (2.1 %) women in the USA ( 98 ).…”

“…According to the literature data, the frequency of the AA genotype ranges from 84.0 % to 95.5 % in healthy Polish ( 80 , 81 , 82 , 84 , 85 , 86 , 87 , 88 ), 86.0 % to 90.4 % in Turkish ( 89 , 90 , 91 , 92 , 93 , 94 ), and about 82 % in Japanese population ( 95 , 96 ). The highest frequencies were found in a healthy Spanish population (97.9 %) ( 97 ), US black women (97.9 %) ( 98 ), Croatian women (93–94.0 %) (4, 99), and a healthy Chinese population (92.5 %) ( 100 ). The lowest frequency of 57.8 % and 53.4 % was found in healthy Iranian and Columbian populations, respectively ( 101 , 102 ).…”

“…The lowest frequency of 57.8 % and 53.4 % was found in healthy Iranian and Columbian populations, respectively ( 101 , 102 ). The frequency of the AG ranged from 2.1 % in healthy Spanish population ( 97 ) and black US women ( 98 ) to 37.8 % and 43.6 % in Iranian and Columbian population, respectively ( 101 , 102 ). We conducted the first study of that kind in Croatia and found that nearly 6 % of the healthy postpartum women were G allele carriers ( 4 ).…”