Metals and the cell surface of Cryptococcus neoformans

Xue, Peng; Hu, Guanggan; Jung, Won Hee; Kronstad, James W.

doi:10.1016/j.mib.2023.102331

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Neoformans' Melanization In Human Brain Tissue1

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2024

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Cited by 8 publications

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“…For C. neoformans SC fungi, the cell surface features that contribute to pathogenesis include the deposition of melanin in the cell wall [55,56]. The melanin deposition in C. neoformans SC is determined by the composition and flexibility of its cell wall [57].…”

Section: Neoformans' Melanization In Human Brain Tissuementioning

confidence: 99%

Connecting Cryptococcal Meningitis and Gut Microbiome

Ma,

Yang,

Jiang

et al. 2023

IJMS

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Fungal pathogens of the Cryptococcus neoformans species complex (C. neoformans SC) are a major cause of fungal meningitis in immunocompromised individuals. As with other melanotic microorganisms associated with human diseases, the cell-wall-associated melanin of C. neoformans SC is a major virulence factor that contributes to its ability to evade host immune responses. The levels of melanin substrate and the regulation of melanin formation could be influenced by the microbiota–gut–brain axis. Moreover, recent studies show that C. neoformans infections cause dysbiosis in the human gut microbiome. In this review, we discuss the potential association between cryptococcal meningitis and the gut microbiome. Additionally, the significant potential of targeting the gut microbiome in the diagnosis and treatment of this debilitating disease is emphasized.

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Section: Neoformans' Melanization In Human Brain Tissuementioning

confidence: 99%