2022
DOI: 10.1007/s12013-022-01106-z
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Metaphase Cells Enrichment for Efficient Use in the Dicentric Chromosome Assay

Abstract: The dicentric chromosome assay (DCA), is considered the 'gold standard' for radiation biodosimetry. Yet, DCA, as currently implemented, may be impractical for emergency response applications, especially when time is of the essence, owing to its labor-intensive and time-consuming nature. The growth of a primary lymphocyte culture for 48h in-vitro is required for DCA, and manual scoring of dicentric chromosomes (DCs) requires an additional 24-48h, resulting in an overall processing time of 72-96h for dose estima… Show more

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