Metaplastic carcinoma of the breast: a clinical and pathological study of 40 cases

Arce-Grijalva, Verónica; Vela-Chávez, Teresa; Pérez-Sánchez, Víctor Manuel; Ruvalcaba-Limón, Eva

doi:10.1186/1471-2407-7-s1-a6

Cited by 5 publications

(7 citation statements)

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“…Our results cope with the previous data as all patients presented with unilateral breast mass; 42.9% associated with nipple discharge, 4.8% with inflammatory breast mass and 14.3% with recurrence. The median tumor size was 8.5 cm compared to a maximum of 5 cm reported in many series [2,3,15,17]; however, it was similar to other reports that documented larger tumor sizes in MBC versus ductal carcinoma [14,20,21].…”

Section: Discussionsupporting

confidence: 82%

“…These figures are within the reported range for MBC [18,21], but contrast to other studies, in which most of the cases presented with advanced stages [3,12]. Analysis of MBC revealed low positive rates of ER, PR expression ranging from 7.1% to 14.3% [3,22].…”

Section: Discussioncontrasting

confidence: 64%

“…Based on WHO classification, 76.2%of cases in the current study were pure epithelial tumors and 23.8% were mixed epithelial and mesenchymal tumors. In comparison, Tse et al [12], identified 24 cases of MBC; 58% being biphasic and 42% being monophasic, whilst, in other two studies half of cases were diagnosed as pure epithelial tumors and half as mixed epithelial and mesenchymal tumors [15,21].…”

Section: Discussionmentioning

confidence: 93%

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Analysis of metaplastic breast carcinoma: FNAC; histopathology and immunohistochemistry are complementary for diagnosis

hafez

Shawky

2013

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Section: Discussionsupporting

confidence: 82%

Section: Discussioncontrasting

confidence: 64%

Section: Discussionmentioning

confidence: 93%

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Analysis of metaplastic breast carcinoma: FNAC; histopathology and immunohistochemistry are complementary for diagnosis

hafez

Shawky

2013

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“…But in another study carried out by Brenner R.J. found the median age was 65.5 years ranging from 33 -87 years and study conducted by Beatty J.D. reported the mean age 55 years ranging from 26 -80 years [26] [27]. In current study we identified four subtypes of metaplastic carcinoma of breast including adenosquamous carcinoma, monotonic spindle cell carcinoma, adenocarcinoma with spindle cell metaplasia and metplastic carcinoma with osteoclast giant cell.…”

Section: Discussionmentioning

confidence: 75%

“…Whereas Arce-Grijalval in their study proposed 0.6% cases of metaplastic carcinoma of breast out of all breast cancer cases registered in the Instituto National de Cancerologia from 1995-2005 [26]. Mean age of patients diagnosed with metaplastic carcinoma in our study was 40 years ranging from 25 -50 years.…”

Section: Discussionmentioning

confidence: 84%

Metaplastic Carcinoma of the Breast: A Clinical Study of 7 Cases from Balochistan

Baloch¹,

Daud²,

Shuja³

et al. 2014

ABCR

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Metaplastic carcinomas of the breast are rare heterogenous neoplasms characterized by adenocarcinoma with dominant areas of spindle cells, squamous and/or other mesenchymal differentiation, that comprise of <5% of all invasive breast cancers. Our objective in this study was to review the pathological features and clinical outcomes for metaplastic carcinoma of breast in breast cancer patients registered in CENAR (Center for Nuclear Medicines and Radiotherapy), Balochistan. Present study was performed on 7 patients affected with metaplastic carcinoma of breast, who were registered patients in CENAR. Informed consent was taken from the patients and BMI was calculated by measuring the height and weight of the patients. Available clinical history obtained by retrieving the patients file and a copy of biopsy report was also obtained from the file. Metaplastic carcinoma of breast was 4.11% of all 170 breast cancer cases registered in CENAR from 2010-2012. Mean age was 40 years ranging from 25 -50 years. Four subtypes of metaplastic carcinoma of breast were reported in this study; DCIS component was present in one case and mean tumor size was 6.12 cm ranging from 3.5 -10 cm. Metaplastic carcinomas of breast are rare heterogenous neoplasm with different characteristics, demographics and tumor biology and accounts for almost >5% of all breast cancer cases.

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Mixed metaplastic carcinoma of the breast associated with pregnancy: Diagnostic dilemmas in fine‐needle aspiration cytology

Σκάγιας

Vasou

Michalopoulou

et al. 2009

Diagnostic Cytopathology

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Metaplastic carcinoma of the breast represents a rare entity characterized by the simultaneous presence of ductal, squamous, and/or mesenchymal components in several proportions. There are limitations in fine-needle aspiration diagnosis due to its pathological heterogeneity. When it develops under pregnancy and lactation influence, the cytologic evaluation appears to be more difficult and accurate diagnosis often proves challenging. We describe a case of mixed metaplastic carcinoma with dominant areas of squamous metaplasia, sarcomatoid stroma with spindle cells, and a minor component of cartilaginous metaplasia. We notify our experience in diagnostic approach of this entity focusing on differential diagnosis.

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Metaplastic carcinoma of the breast: a clinical and pathological study of 40 cases

Cited by 5 publications

References 0 publications

Analysis of metaplastic breast carcinoma: FNAC; histopathology and immunohistochemistry are complementary for diagnosis

Analysis of metaplastic breast carcinoma: FNAC; histopathology and immunohistochemistry are complementary for diagnosis

Metaplastic Carcinoma of the Breast: A Clinical Study of 7 Cases from Balochistan

Mixed metaplastic carcinoma of the breast associated with pregnancy: Diagnostic dilemmas in fine‐needle aspiration cytology

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