Metastases of Renal Cell Carcinoma to the Contralateral Adrenal Gland Managed by Laparoscopic Adrenalectomy

Nerli, Rajendra B; Patil, Shital; Pathade, Amey; Patil, Ranjeet; Pingale, Nitin; Malur, Prakash R

doi:10.1007/s13193-017-0662-1

Cited by 6 publications

(5 citation statements)

References 12 publications

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“…The presence of a well vascularized solitary adrenal mass with normal hormonal studies is more suggestive of metastatic lesion rather than primary adrenal mass. In 82% of the reported CAM cases diagnosis was made through CT scan, thus it is the imaging of choice [3]. Similarly in our patient the findings in CT scan were consistent with adrenal metastasis.…”

Section: Discussionsupporting

confidence: 74%

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Solitary contralateral adrenal metastasis of renal cell carcinoma 15 years following radical nephrectomy: A case report and review of literature

Ahmed

Bapir

Abdula

et al. 2019

International Journal of Surgery Case Reports

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Highlights A well-recognized phenomenon in RCC is late metastatic recurrence after nephrectomy. Solitary contralateral adrenal metastatic recurrence of RCC is extremely rare. Early diagnosis of adrenal metastasis is challenging because they are usually silent. This paper is the delayed solitary metastatic recurrence of the renal cell carcinoma to the contralateral adrenal gland.

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Section: Discussionsupporting

confidence: 74%

“…The incidence of solitary ipsilateral and contralateral adrenal metastasis is 3% and 0.7% respectively in patients who have underwent radical nephrectomy. Good prognostic signs include an early stage and low grade tumor with a long interval from the diagnosis to the development of metastasis [3]. In line with the SCARE criteria [4].…”

Section: Introductionmentioning

confidence: 99%

Solitary contralateral adrenal metastasis of renal cell carcinoma 15 years following radical nephrectomy: A case report and review of literature

Ahmed

Bapir

Abdula

et al. 2019

International Journal of Surgery Case Reports

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“…Contralateral adrenal metastasis has been reported in the literature as late as 23 years post-RCC diagnosis; among various RCC subtypes, most reports show clear cell histology [ 6 ]. Late contralateral adrenal metastasis recurrence following radical nephrectomy has only been documented in a handful of cases and is theorized to be due to one of the two primary reasons [ 7 ]: the slow growth of tumors in the case of low-grade tumors and loss to follow-up with regular surveillance imaging.…”

Section: Discussionmentioning

confidence: 99%

Metachronous Renal Cell Carcinoma: A Rare Presentation of Adrenal Crisis

Doodnauth

Waqar

Klar

et al. 2021

Cureus

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Responsible for 2% of global cancer diagnoses, renal cell carcinoma (RCC) can metastasize to almost every organ system; however, metastasis to the contralateral adrenal gland is extremely rare. We report the case of a 59-year-old male who presented with atypical chest pain and altered mental status. The patient developed hypotension, with hyponatremia raising concern for adrenal insufficiency (AI). We confirmed a diagnosis of AI secondary to adrenal metastasis in the setting of radical nephrectomy with ipsilateral adrenalectomy, and the patient’s symptoms resolved with adequate treatment. This report emphasizes the importance of complications caused by metastatic disease to the remaining adrenal gland in patients with RCC who have undergone ipsilateral radical nephrectomy.

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“…In this subgroup, patients with a solitary adrenal metastasis (n = 18) had better survival rates than those with multiple metastases (n = 36) (5-year OS 61% vs. 19.6%; p < 0.05). More recently, Nerli et al prospectively followed RCC patients treated with partial or radical nephrectomy for the subsequent development of adrenal masses; in their cohort, 8 patients developed adrenal lesions and underwent laparoscopic MTX (76). Mean OS was determined to be 44.62 months, and no perioperative morbidity or mortality was observed.…”

Section: Livermentioning

confidence: 99%

Role of metastasectomy in the management of renal cell carcinoma

et al. 2022

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Treatment of metastatic renal cell carcinoma (mRCC) has evolved with the development of a variety of systemic agents; however, these therapies alone rarely lead to a complete response. Complete consolidative surgery with surgical metastasectomy has been associated with improved survival outcomes in well-selected patients in previous reports. No randomized control trial exists to determine the effectiveness of metastasectomy. Therefore, reviewing observational studies is important to best determine which patients are most appropriate for metastasectomy for mRCC and if such treatment continues to be effective with the development of new systemic therapies such as immunotherapy. In this narrative review, we discuss the indications for metastasectomies, outcomes, factors associated with improved survival, and special considerations such as location of metastasis, number of metastases, synchronous metastases, and use of systemic therapy. Additionally, alternative treatment options and trials involving metastasectomy will be reviewed.

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Metastases of Renal Cell Carcinoma to the Contralateral Adrenal Gland Managed by Laparoscopic Adrenalectomy

Cited by 6 publications

References 12 publications

Solitary contralateral adrenal metastasis of renal cell carcinoma 15 years following radical nephrectomy: A case report and review of literature

Solitary contralateral adrenal metastasis of renal cell carcinoma 15 years following radical nephrectomy: A case report and review of literature

Metachronous Renal Cell Carcinoma: A Rare Presentation of Adrenal Crisis

Role of metastasectomy in the management of renal cell carcinoma

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