Metastasierung von Malignomen des Uterus und therapeutische Konsequenzen

Lax, Sigurd; Tamussino, Karl; Lang, Pencilla

doi:10.1007/s00292-016-0243-z

Cited by 6 publications

(3 citation statements)

References 46 publications

(26 reference statements)

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“…The disease usually spreads locally or by lymphatic dissemination [28,29]. Distant metastases are less common and usually involve the lungs and liver as per hematogenous spread.…”

Section: Incidence and Risk Factorsmentioning

confidence: 99%

Cutaneous Metastasis of Endometrial Cancer and Long-Term Survival: A Scoping Review and Our Experience

Nienhaus,

Rajakulendran,

Bernad

2023

Diagnostics

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Background and Objectives: Cutaneous and soft tissue metastases of endometrial cancer are rare. This review aims to examine the prevalence of cutaneous metastasis, the diagnosis and treatment options, and the impact of cutaneous metastasis of endometrial cancer on overall survival. We also present a particular case with a long-term overall survival. Materials and Methods: A systematic literature search was conducted on PubMed and PubMed Central using the following keywords: endometrial carcinoma metastasis, cutaneous metastasis, and five-year overall survival. Results: We identified 326 results and checked their titles for eligibility. There were eight studies included. We also presented a case of a 51-year-old woman with cutaneous metastasis and a large soft tissue metastasis with a prolonged overall survival of about 13 years after the appearance of the first cutaneous metastasis. Conclusions: This paper highlights the importance of skin evaluations in patients diagnosed with endometrial cancer. Healthcare providers must consider the possibility of cutaneous metastasis localization in patients with endometrial cancer to assign the correct stage and apply the appropriate treatment to increase long-term survival.

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“…The disease usually spreads locally or by lymphatic dissemination [28,29]. Distant metastases are less common and usually involve the lungs and liver as per hematogenous spread.…”

Section: Incidence and Risk Factorsmentioning

confidence: 99%

Cutaneous Metastasis of Endometrial Cancer and Long-Term Survival: A Scoping Review and Our Experience

Nienhaus,

Rajakulendran,

Bernad

2023

Diagnostics

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“…It is most often characterised by the proliferation of malignant glandular epithelial cells within the endometrium. While its metastatic progression frequently involves adjacent tissues, it can also involve distant organs such as the lungs, liver and bones 1–4. Previous literature has documented metastases to the skin in locations such as the shoulder, leg, abdomen and vagina; however, to our knowledge, there have been no reported cases of cutaneous metastases to the digits (table 1).…”

Section: Introductionmentioning

confidence: 97%

From endometrium to fingernail bed: histological evaluation of a rare cutaneous metastasis

Alomary,

Schwartz,

Lambert

et al. 2024

BMJ Case Rep

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In the dermatological spectrum of oncologic manifestations, cutaneous metastases from endometrial carcinoma stand as a rarity, given the tumour’s predilection for neighbouring uterine regions. We present an exceptional case of a patient in her mid-50s, whereby an endometrial carcinoma, defying conventional pathways, manifested on the skin and nail of her distal fourth finger, an unusual site for cutaneous metastases, with a specific histology of the primary cancer.

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“…Brain metastasis is extremely rare. 5 The aim of this study is to describe a case of papillary serous adenocarcinoma of the endometrium that progressed to brain and bone metastases.…”

Section: Introductionmentioning

confidence: 99%

Brain Metastasis in Papillary Serous Adenocarcinoma of the Endometrium

Filho

Fé

Rodrigues

et al. 2019

Rev Bras Ginecol Obstet

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Background Most endometrial cancers (75%) are diagnosed in early stages (stages I and II), in which abnormal uterine bleeding is the most frequent clinical sign. When the diagnosis is performed in stage IV, the most common sites of metastasis are the lungs, liver and bones. Central nervous system (CNS) metastasis is a rare condition. The aim of this study is to describe a case of uterine papillary serous adenocarcinoma of the endometrium that progressed to brain and bone metastases. Case Report We present the case of a 56-year-old woman with abnormal uterine bleeding and endometrial thickened echo (1.8 cm). A hysteroscopy with biopsy was performed, which identified poor differentiated serous adenocarcinoma of the endometrium. A total abdominal hysterectomy, with pelvic and para-aortic lymphadenectomy, was performed. Analysis of the surgical specimen revealed a grade III uterine papillary serous adenocarcinoma. Adjuvant radio/chemotherapy (carboplatin and paclitaxel—six cycles) was indicated. Sixteen months after the surgery, the patient began to complain of headaches. Brain magnetic resonance imaging demonstrated an expansile mass in the right parietal lobe, suggesting a secondary hematogenous implant subsequently confirmed by biopsy. She underwent surgery for treatment of brain metastasis, followed by radiotherapy. She died 12 months after the brain metastasis diagnosis due to disease progression. Conclusion Uterine papillary serous adenocarcinoma of the endometrium has a low propensity to metastasize to the brain. To the best of our knowledge, this is the fifth documented case of uterine papillary serous adenocarcinoma of the endometrium with metastasis to the CNS.

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Metastasierung von Malignomen des Uterus und therapeutische Konsequenzen

Cited by 6 publications

References 46 publications

Cutaneous Metastasis of Endometrial Cancer and Long-Term Survival: A Scoping Review and Our Experience

Cutaneous Metastasis of Endometrial Cancer and Long-Term Survival: A Scoping Review and Our Experience

From endometrium to fingernail bed: histological evaluation of a rare cutaneous metastasis

Brain Metastasis in Papillary Serous Adenocarcinoma of the Endometrium

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