Metastasis to the Breast from Nonmammarian Solid Neoplasms: A Report of Five Cases

Öksüzoğlu, Berna; Abalı, Hüseyin; Güler, Nilüfer; Baltali, E; Özışık, Yavuz

doi:10.1385/mo:20:3:295

Cited by 37 publications

(26 citation statements)

References 21 publications

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“…[25][26][27][28][29][30][31] In two different series of metastatic tumors to the breast, each reported four adolescent girls with metastatic rhabdomyosarcoma involving the breast. The alveolar subtype has been reported to occur much more commonly than embryonal, which is well known to be much more aggressive.…”

Section: Discussionmentioning

confidence: 99%

Non-mammary metastases to the breast and axilla: a study of 85 cases

et al. 2013

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Non-mammary metastases to the breast and axilla are rare occurrences. However, they are important diagnostic considerations as their treatment and prognosis differ significantly from primary breast cancer. Between 1990 and 2010, we identified a total of 85 patients, 72 women and 13 men, with non-mammary malignancies involving the breast, axilla, or both. The tumor types consisted of carcinoma (58%), melanoma (22%) and sarcoma (20%). Ovary was the most common site of origin for carcinoma, and metastatic high-grade ovarian serous carcinoma was most frequently misdiagnosed as a primary breast carcinoma. Melanoma was the single most common non-carcinomatous tumor type to involve the breast and/or axilla, and uterine leiomyosarcoma was the most common type of sarcoma. Most patients (77%) had other metastases at the time of diagnosis of the tumor, but in 11% the breast or axillary lesion was the first presentation. Without a clinical history, non-mammary metastases were difficult to diagnose because the majority of cases presented with a solitary nodule and lacked pathognomonic pathologic features. There were, however, certain recurrent histological findings identified, such as the often relatively well-circumscribed growth pattern of the metastatic lesion surrounded by a fibrous pseudocapsule, and the absence of an in situ carcinoma. Overall, these patients had poor survival; 96% of patients with follow-up available are dead of disease, with a median survival of 15 months after the diagnosis of the breast or axillary lesion. This finding emphasizes the need to accurately identify these tumors as metastases in order to avoid unnecessary procedures and treatments in these patients. Keywords: axilla; breast; extramammary Metastases to the breast and axilla are rare and account for approximately 2% of all mammary malignancies. 1,2 The most common metastatic lesion to involve the breast is a metastasis from a contralateral mammary cancer. 1,2 If hematologic malignancies are also excluded, the number of non-mammary metastases drops to well below 1%. 1,3 Owing to the frequency of primary breast cancers and the rarity of non-mammary tumors involving the breast, a newly discovered lesion in the breast or axilla is usually presumed to be a primary or metastatic breast carcinoma. However, the recognition of non-mammary metastases to the breast and axilla is very important, as both the treatment and prognosis differ significantly. Materials and methodsAfter obtaining approval by our Institutional Review Board, we searched the pathology database of Memorial Sloan-Kettering Cancer Center between the years 1990-2010 for patients with non-mammary metastases to the breast and axilla. Hematologic malignancies were excluded, as they are systemic diseases. The medical records and pathology slides, when available, were reviewed and the clinicopathologic characteristics were recorded. Patient age, gender, primary tumor site, the presence of other metastases, laterality, number of lesions, interval from primary tumor diagnosis to breast/ a...

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Section: Discussionmentioning

confidence: 99%

Non-mammary metastases to the breast and axilla: a study of 85 cases

et al. 2013

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“…In clinical series it represents 0.5%-1.5% of all breast malignancies (1,2). The most primary cancers metastasis to breast are melanoma, leukemia, lymphoma, and cancer of the lung, stomach, prostate and ovary (3,4).…”

Section: Discussionmentioning

confidence: 99%

“…It represents 0.5-1.5% of all breast malignancies in clinical series and 6.6% in autopsy series (1,2). The common primary sites are malignant melanoma, leukemia, lymphoma, and cancer of the lung, stomach, prostate and ovary (3,4). The cervical origin is rarely reported, and often represents widespread disease with poor prognosis.…”

Section: Introductionmentioning

confidence: 99%

Breast metastasis from squamous cell carcinoma of the cervix: a case report

Kemal¹,

Demirağ²,

Karagöz³

et al. 2015

Acta Oncol Tur.

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ÖZETSolid tümörlerin meme metastazına çok sık olmasa da klinik pratik hayatımızda rastlamaktayız ancak servikal kanserin memeye yayılımı literatürde de çok nadir bildirilmektedir. Olgumuz 65 yaşında, evre IV yassı hücreli serviks kanseri nedeni ile 3 kür birinci seri kemoterapi aldıktan sonra meme metastazı gelişti. Primer meme kanseri düşünülerek alınan biyopsinin patolojik incelenmesinde az diferansiye yassı hücreli kanser metastazı olduğu görüldü. Bu olgu kanser öyüsü olan hastalarda doğru tedavi kararı verebilmek için ayırıcı tanının önemini bir kez daha vurgulamaktadır. Anahtar Kelimeler: serviks kanseri, meme metastazı ABSTRACT Breast metastasis from other solid tumors are infrequent, and cervical cancer is the extermely rare primary site. We describe a case of 65 years old women with stage IV cervical squamous cell carcinoma. After three cycles of the first line chemotherapy, she developed breast metastasis mimicking the primary breast cancer. Histopathological examination of the breast trucut biopsy performed and less differantieted epidermoid carcinoma was deteremined. Differential diagnosis from primary breast cancer is crtical to decide most appropriate treatment especially in patients with previous cancer history.

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“…The metastatic involvement of the breast from non-mammary neoplasms is a relatively rare condition (1). We report a case of small cell lung cancer associated with a metastatic lesion to the breast with a review of the literature about this rare entity.…”

Section: Anahtar Sözcükler: Meme Metastaz Küçük Hücreli Akciğer Kanmentioning

confidence: 97%

Small-cell lung cancer metastases in breast

Demirci¹,

Erdoğan²,

Demırağ³

et al. 2014

Respir Case Rep

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Although primary breast tumors are quite common, metastatic involvement of all breast masses are rare and account for about 1-5% of cases. A 56-year-old female patient was admitted to our clinic in July 2009 with complaints of shortness of breath. Thoracic computed tomography (CT) scan showed a mass in the left hilar region. Endobronchial lesion was determined by fiberoptic bronchoscopy and the biopsy was evaluated as small cell lung carcinoma. The patient was followed-up after 4 cycles of etoposide + cisplatin chemotherapy. In the follow-up period, due to an increase in shortness of breath the patient was admitted to our clinic again in April 2010. A 4x3x3 cm sized mass in the right upper quadrant of breast lesions obtained for re-staging positron emission tomography (PET-CT) showed intense FDG uptake increase. Needle biopsy of the breast was evaluated as a result of metastasis of small cell lung carcinoma. The patient recieved second-line VAC chemotherapy in April 2010. This case of small-cell lung cancer and breast metastases is presented because of its rarity. Key words: Breast, metastasis, small cell lung carcinoma.Primer meme tümörleri yaygın olmasına rağmen memenin metastatik tutulumu nadirdir ve yaklaşık %1-5 oranında görülür. Elli altı yaşında kadın hasta Temmuz 2009'da nefes darlığı yakınması ile kliniğimize başvurdu. Toraks bilgisayarlı tomografisinde (BT) sol hiler kitle mevcuttu. Fiberoptik bronkoskopi ile saptanan endobronşiyal lezyondan alınan biyopsi sonucu küçük hücreli akciğer karsinomu (KHAK) olarak geldi. Hastaya 4 kür etoposid sisplatin kemoterapisi verildi ve sonrasında takibe alındı. Nisan 2010'da nefes darlığında artış yakınması ile tekrar kliniğimize kabul edildi. Yeniden evreleme amaçlı çekilen PET-BT'de sağ meme dış kadranda 4x3x3 cm ebadında SUVmax 13,29 olan artmış FGD tutulumu raporlandı. Memedeki lezyondan alınan biyopsi sonucu KHAK metastazı şeklinde değerlendi-rildi. Hastaya 2. basamak VAC (vincristin, adriyamisin, siklofosfamid) kemoterapisi başlandı. KHAK'nin memeye metastazı nadir olması nedeni ile sunuldu.Anahtar Sözcükler: Meme, metastaz, küçük hücreli akciğer kanseri.

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Metastasis to the Breast from Nonmammarian Solid Neoplasms: A Report of Five Cases

Cited by 37 publications

References 21 publications

Non-mammary metastases to the breast and axilla: a study of 85 cases

Non-mammary metastases to the breast and axilla: a study of 85 cases

Breast metastasis from squamous cell carcinoma of the cervix: a case report

Small-cell lung cancer metastases in breast

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