Metastasis to the gallbladder: A single-center experience of 20 cases in South Korea

Yoon, Won Jae; Yoon, Yong Bum; Kim, Youn Joo; Ryu, Ji Kon; Kim, Yong Tae

doi:10.3748/wjg.15.4806

Cited by 48 publications

(42 citation statements)

References 9 publications

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“…In the western medical literature, the most common primary tumor to metastasize to the gallbladder is melanoma, which represents 60% of all gallbladder metastases (Fig 10) (57). In the Asian medical literature, the most common source of gallbladder metastases is gastric cancer (58). Cancers of the kidney and lung may hematogenously spread to the gallbladder, whereas hepatocellular carcinoma and cholangiocarcinoma may directly invade the gallbladder (Fig 11).…”

Section: Metastatic Disease and Lymphoma-me-mentioning

confidence: 99%

Polypoid Lesions of the Gallbladder: Disease Spectrum with Pathologic Correlation

Mellnick¹,

Menias

Sandrasegaran³

et al. 2015

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Gallbladder polyps are seen on as many as 7% of gallbladder ultrasonographic images. The differential diagnosis for a polypoid gallbladder mass is wide and includes pseudotumors, as well as benign and malignant tumors. Tumefactive sludge may be mistaken for a gallbladder polyp. Pseudotumors include cholesterol polyps, adenomyomatosis, and inflammatory polyps, and they occur in that order of frequency. The most common benign and malignant tumors are adenomas and primary adenocarcinoma, respectively. Polyp size, shape, and other ancillary imaging findings, such as a wide base, wall thickening, and coexistent gallstones, are pertinent items to report when gallbladder polyps are discovered. These findings, as well as patient age and risk factors for gallbladder cancer, guide clinical decision making. Symptomatic polyps without other cause for symptoms, an age over 50 years, and the presence of gallstones are generally considered indications for cholecystectomy. Incidentally noted pedunculated polyps smaller than 5 mm generally do not require follow-up. Polyps that are 6-10 mm require follow-up, although neither the frequency nor the length of follow-up has been established. Polyps that are larger than 10 mm are typically excised, although lower size thresholds for cholecystectomy may be considered for patients with increased risk for gallbladder carcinoma, such as patients with primary sclerosing cholangitis.

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Section: Metastatic Disease and Lymphoma-me-mentioning

confidence: 99%

Polypoid Lesions of the Gallbladder: Disease Spectrum with Pathologic Correlation

Mellnick¹,

Menias

Sandrasegaran³

et al. 2015

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“…Metastasis to the gallbladder originating from stomach cancer had not been reported until the study of Yoon et al (4). The authors analyzed 417 cases with gallbladder malignancies.…”

Section: Discussionmentioning

confidence: 99%

“…The patients with isolated GBM from the other malignancies generally present with obstructive jaundice if the tumor is located in the common bile duct or with upper abdominal pain mimicking symptomatic cholecystolithiasis (3,11,12), but asymptomatic cases were also reported (4,12). Our patient presented with right upper abdominal pain and fever without obstructive jaundice; therefore, our patient was compatible with the literature.…”

Section: Discussionmentioning

confidence: 99%

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Gallbladder metastasis secondary to gastric cancer as a first site of recurrence presented with acute cholecystitis: Case report and literature review

Bılıcı

Şeker²,

Ustaalıoğlu³

et al. 2012

Turk J Gastroenterol

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“…Cholecystectomy with R0 resection has been demonstrated to be the only factor that increases survival, mainly in isolated cases of metastasis (4,10). Acute cholecystitis as a clinical presentation is associated with poor prognosis (10).…”

Section: Metastasis Of the Gallbladder In Clear Cell Renal Carcinomamentioning

confidence: 99%

Metastasis of the gallbladder in clear cell renal carcinoma

et al. 2012

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Abstract. Metastasis of the gallbladder due to renal cell tumors is rare. We present a case of gallbladder and metachronous left adrenal metastasis at six months follow-up, which demonstrates the importance of radiological tests and histology when making a definitive diagnosis. Clinical findings are not specific enough to arrive at a final diagnosis. However, immunohistochemistry is necessary to differentiate between primary and secondary metastatic tumors. Cholecystectomy should be performed to obtain a definitive diagnosis and to improve survival in cases of single lesions in the gallbladder. IntroductionClear cell renal carcinoma (RCC) is a rare tumor accounting for 3% of all malignancies in adults and 85% of primary renal tumors (1). Currently, its incidence is on the increase due to the increased number of incidental findings in imaging tests (2). RCC frequently metastasizes in the lungs, bones, lymph nodes and liver. Gallbladder metastasis is extremely rare, being found in approximately 0.6% of cases at autopsy (3). We report a case of gallbladder and metachronous contralateral adrenal metastasis. The study was approved by the ethics committee of La Fe University Hospital, and consent was obtained from the patient. Case reportA 75-year-old female was incidentally diagnosed with right RCC following radiological tests requested for benign anorectal disease in March 2010. Computed tomography (CT) revealed a right renal mass of 11.3x8.6x12.2 cm with areas of necrosis, calcification, increased neovascularization and exophytic growth towards the liver. In addition, lymph nodes were detected in the renal hilum and retroperitoneum, with uncertain infiltration of the renal vein and inferior vena cava without distant metastases. The tumor markers CEA and CA19.9 were within the normal range. A radical right nephrectomy was carried out through a right subcostal incision without demonstrable vascular invasion or metastases intraoperatively. Macroscopically, the renal lesion was yellowish in appearance, with undefined limits and a confluent nodular pattern with fibrous areas.The patient's postoperative course was uneventful and systemic adjuvant therapy was not administered. The pathological study revealed a typical RCC with a solid growth pattern without invasion of the renal pelvic wall and tumor thrombosis in the renal vein. Surgical margins were tumor-free and all lymph nodes dissected were free of tumor infiltration, with stage pT3N0M0.A CT scan was performed at 6 months which showed a nodular lesion of 3 cm in the left adrenal gland and a lobulated lesion in the gallbladder wall, with the suspected diagnosis of metastasis. Ultrasonography (US) revealed a heterogeneous solid nodular structure of 2 cm with poor delineation of the gallbladder wall. It was not possible to exclude infiltration of the liver parenchyma (Fig. 1). The extension study was completed with a thoracic CT, which revealed no pathological findings. Tumor markers were also within normal ranges.A midline laparotomy was carried out and the patient un...

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Metastasis to the gallbladder: A single-center experience of 20 cases in South Korea

Cited by 48 publications

References 9 publications

Polypoid Lesions of the Gallbladder: Disease Spectrum with Pathologic Correlation

Polypoid Lesions of the Gallbladder: Disease Spectrum with Pathologic Correlation

Gallbladder metastasis secondary to gastric cancer as a first site of recurrence presented with acute cholecystitis: Case report and literature review

Metastasis of the gallbladder in clear cell renal carcinoma

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