2005
DOI: 10.1002/cncr.21263
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Metastatic osteosarcoma at diagnosis

Abstract: Blends of polypropylene (PP) and thermoplastic elastomers (TPE), namely SBS (styrene‐butadiene‐styrene) and SEBS (styrene‐ethylene/1‐butene‐styrene) block copolymers, were prepared to evaluate the effectiveness of the TPE type as an impact modifier for PP and influence of the concentration of elastomer on the polymer properties. Polypropylene homopolymer (PP‐H) and ethylene–propylene random copolymer (PP‐R) were evaluated as the PP matrix. Results showed that TPEs had a nucleating effect that caused the PP cry… Show more

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Cited by 239 publications
(115 citation statements)
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“…Between 25 and 40% of patients with localized disease will suffer a metastatic recurrence, and up to 75% of these patients will die of their disease [22-25]. These numbers have not significantly changed since the 1980s, despite numerous clinical trials aimed at improving the efficacy of chemotherapy.…”
Section: Discussionmentioning
confidence: 99%
“…Between 25 and 40% of patients with localized disease will suffer a metastatic recurrence, and up to 75% of these patients will die of their disease [22-25]. These numbers have not significantly changed since the 1980s, despite numerous clinical trials aimed at improving the efficacy of chemotherapy.…”
Section: Discussionmentioning
confidence: 99%
“…OS has high local aggressiveness and occasionally metastasis to lung and other bone sites, with few occasions to lymphoid metastasis[4]. Recently, the combination of practicable surgery and chemotherapy improve the long-term survival of approximately 60–70% that prolong the survival rate of OS[5]. Nonetheless, issue such as complementary treatments before OS diagnosis affecting the clinical outcome remains important but less discussed.…”
Section: Introductionmentioning
confidence: 99%
“…Although advances in tumor treatment strategy have significantly raised the survival rate of osteosarcoma patients, the survival of osteosarcoma patients with metastatic disease or recurrences and those in advanced stage is still quite poor [3,[6][7][8]. Thus, novel promising biomarkers of osteosarcoma that can help in diagnosis and prognosis evaluation are still urgently needed.…”
Section: Discussionmentioning
confidence: 99%
“…With the application of chemotherapy, a combination of neoadjuvant chemotherapy, surgery resection and postoperative chemotherapy has clinically become the standard treatment strategy for osteosarcoma and has significantly improved patients' outcome, the 5-year overall survival of patients with nonmetastatic osteosarcoma of the extremity has approached to 70%~80% over past decades [5,6]. However, the 5-year overall survival rate of osteosarcoma patients with detectable metastases at diagnosis is as low as 19% [7]. Those patients with recurrent disease also have unsatisfactory 5-year post-relapse-overall-survival (PROS) rate, which is about 30% [8].…”
Section: Introductionmentioning
confidence: 99%