Metastatic pattern in esophageal and gastric cancer: Influenced by site and histology

Verstegen, Moniek; Harker, Mitchell; Water, Carlijn van de; Dieren, Jolanda van; Hugen, Niek; Nagtegaal, Irıs D.; Rosman, Camiel; Post, Rachel S. van der

doi:10.3748/wjg.v26.i39.6037

Cited by 52 publications

(44 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to the location of the tumor center, it can be divided into cervical esophagus cancer, upper thoracic esophageal cancer, middle thoracic esophageal cancer, and lower thoracic esophageal cancer. Middle esophageal cancer is the most common in China, followed by lower esophageal cancer [ 7 , 8 ]. Symptoms of esophageal cancer are swallowing obstruction and progressive increase.…”

Section: Resultsmentioning

confidence: 99%

Risk Factors of Acute Radiation-Induced Lung Injury Induced by Radiotherapy for Esophageal Cancer

Zhang¹,

Liu²,

Song³

et al. 2022

Computational and Mathematical Methods in Medicine

View full text Add to dashboard Cite

Objective. To investigate the risk factors of acute radiation-induced lung injury (acute RILI) induced by radiotherapy for esophageal cancer. Methods. A total of 206 patients with esophageal cancer who received radiotherapy in our hospital from January 2017 to March 2020 were selected. The general data such as gender, age, and comorbidities of the patients were collected, as well as the levels of cytokines (TNF-α, TNF-β, and IL-6) in peripheral blood before radiotherapy; radiotherapy dose-related parameters were recorded during radiotherapy. Follow-up was 12 months after radiotherapy. The patients with induced acute RILI after radiotherapy were set as the observation group ( n = 75 ). Patients without acute RILI after radiotherapy were set as the control group ( n = 131 ). Univariate and multivariate logistic regression analysis was performed on the risk factors of acute RILI induced by radiotherapy for esophageal cancer. Results. Univariate analysis and multivariate logistic regression analysis showed that the combined diabetes, total radiation dose, combined lung disease, physical factors (V30, Dmean), and preradiotherapy cytokine (TNF-α, TNF-β, and IL-6) elevated level was an independent risk factor for radiotherapy-induced acute RILI in esophageal cancer ( P < 0.05 ).Conclusion. Concomitant diabetes, total radiation dose, lung disease, physical factors (V30, Dmean), and levels of cytokines (TNF-α, TNF-β, and IL-6) before radiation therapy are risk factors for acute RILI induced by radiation therapy in esophageal cancer. The possibility of acute RILI should be comprehensively assessed according to the patient’s condition, and the radiotherapy regimen should be adjusted to reduce and avoid the induction of acute radiation-induced lung injury.

show abstract

Section: Resultsmentioning

confidence: 99%

Risk Factors of Acute Radiation-Induced Lung Injury Induced by Radiotherapy for Esophageal Cancer

Zhang¹,

Liu²,

Song³

et al. 2022

Computational and Mathematical Methods in Medicine

View full text Add to dashboard Cite

show abstract

“…Patients diagnosed with adenocarcinoma more likely present liver metastasis compared to patients with esophageal squamous cell carcinoma. Bone metastases are more frequent in adenocarcinoma, while lung metastases in squamous cell carcinoma [3]. Patients with stage IV adenocarcinoma also tend to have poorer survival when the bone metastases are identified compared to patients with liver metastasis [4].…”

Section: Discussionmentioning

confidence: 99%

Skull metastasis originating from adenocarcinoma of the esophagogastric junction

Despina¹,

Triantafyllou²,

Theodorou³

2021

J Clin Images Med Case Rep

View full text Add to dashboard Cite

show abstract

“…The cells were cultured in a small dish (3.5 cm) for 72 h, and then the cells were passaged. After the small dish was full (2x10 6 ), the total RNA was extracted for RT-qPCR.…”

Section: Electro Chemiluminescence Immunoassay (Eclia)mentioning

confidence: 99%

“…GC is known to be a highly malignant tumor of the digestive system (1)(2)(3). In recent years, the incidence of GC has steadily declined (4), but there are no specific symptoms in early GC, it is often found to metastasized in distant organs, hsa_circ_0060975 is highly expressed and predicts a poor prognosis in gastric cancer such as liver, lymph node metastasis, peritoneal metastasis and lung (1,(5)(6)(7)(8). Some therapies, such as surgery, radiotherapy and chemotherapy are used to treat GC, but the tumor-free 5-year survival rate of GC is only 20-30% (9).…”

Section: Introductionmentioning

confidence: 99%

hsa_circ_0060975 is highly expressed and predicts a poor prognosis in gastric cancer

Zhang

et al. 2021

Oncol Lett

View full text Add to dashboard Cite

Gastric cancer (GC) is the fifth most common cancer and GC has a high mortality rate worldwide. Circular (circ) RNAs serve an important role in cancer. The present study aimed to investigate the expression level of hsa_circ_0060975 in gastric cancer (GC) and to determine the clinical pathological significance of hsa_circ_0060975 in patients with GC. Reverse transcription-quantitative PCR was used to detect expression level of hsa_circ_0060975 in 192 GC and adjacent non-cancerous gastric tissues, in GC cell lines (MKN-45, HGC27 and AGS) and a human gastric epithelium cell line (GES-1), as well as in plasma samples from 126 patients with GC and 92 healthy volunteers. All plasma and tissue samples of were obtained from The First Affiliated Hospital of Anhui Medical University (Hefei, China). The relationship between hsa_circ_0060975 expression and clinical pathological factors was analyzed using the χ 2 test. The diagnostic value of hsa_circ_0060975 was analyzed using the receiver operating characteristic curve (ROC curve), while the Kaplan-Meier method was used to analyze the relationship of hsa_circ_0060975 expression with the survival of patients with GC as determined by log-rank tests. Univariate and multivariate Cox regression analyses were used to identify the prognostic factors, including hsa_circ_0060975 expression and clinical pathological factors. In addition, the potential function of hsa_circ_0060975 was evaluated via bioinformatics analysis. The expression level of hsa_circ_0060975 was higher in GC tissues compared with adjacent non-cancerous gastric tissues, GC cell lines compared with GES-1 and plasma samples from patients with GC compared with plasma samples from healthy volunteers. In addition, higher hsa_circ_0060975 expression was associated with histological grade, pathological stage and tumor (T) classification in GC tissues and plasma samples (P<0.05). The area under the ROC curves of hsa_circ_0060975, the combination with hsa_circ_0060975 and carcinoembryonic antigen (CEA) or CEA alone were 0.804 (sensitivity, 0.746; specificity, 0.783; P<0.001); 0.931 (sensitivity, 0.937; specificity, 0.870; P<0.001) and 0.924 (sensitivity, 0.937; sspecificity, 0.804; P<0.001) respectively. The Kaplan-Meier survival analysis revealed that the overall survival (OS) and disease-free survival (DFS) time of patients with higher hsa_circ_0060975 expression were shorter compared with those in patients with lower hsa_circ_0060975 expression. Univariate and multivariate Cox regression analyses in OS and DFS time determined that the expression level of hsa_circ_0060975, histological grade and pathological stage were independent prognostic factors for patients with GC. In addition, the bioinformatics analysis results suggested that the abnormal expression of hsa_circ_0060975 may serve an important role in tumorigenesis. Hence, hsa_circ_0060975 expression may be an independent prognostic factor for patients with GC and may be a potential marker for biological malignancy.

show abstract

Metastatic pattern in esophageal and gastric cancer: Influenced by site and histology

Cited by 52 publications

References 28 publications

Risk Factors of Acute Radiation-Induced Lung Injury Induced by Radiotherapy for Esophageal Cancer

Risk Factors of Acute Radiation-Induced Lung Injury Induced by Radiotherapy for Esophageal Cancer

Skull metastasis originating from adenocarcinoma of the esophagogastric junction

hsa_circ_0060975 is highly expressed and predicts a poor prognosis in gastric cancer

Contact Info

Product

Resources

About