Metformin allergy

Wiwanitkit, Viroj

doi:10.4103/0253-7613.77379

Cited by 10 publications

(8 citation statements)

References 5 publications

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“…Cutaneous reactions to oral antidiabetic agents are rather rare. Allergic reactions, leukocytoclastic vasculitis, erythema multiforme and psoriasiform drug eruption have been described to the biguanide drug metformin 111–114 . Furthermore, pemphigus vulgaris and psoriasiform drug eruption have been reported to the sulfonylurea glibenclamide 115–117 .…”

Section: Skin Complications Due To Therapy Of Diabetesmentioning

confidence: 99%

“…Allergic reactions, leukocytoclastic vasculitis, erythema multiforme and psoriasiform drug eruption have been described to the biguanide drug metformin. [111][112][113][114] Furthermore, pemphigus vulgaris and psoriasiform drug eruption have been reported to the sulfonylurea glibenclamide. [115][116][117] It should be beared in mind that most of the sulfonylureas induce cutaneous photosensitivity.…”

Section: Cutaneous Reactions To Oral Antidiabetic Agentsmentioning

confidence: 99%

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Skin signs in diabetes mellitus

Behm

Schreml

Landthaler

et al. 2012

Acad Dermatol Venereol

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Diabetes mellitus is the most common endocrine disorder with continuously increasing prevalence. Blood vessels, nerves, eyes, kidneys and skin are affected, which causes both an enormous financial burden and a reduced quality of life of the affected patients. Long-standing diabetes may impair skin homeostasis resulting in skin manifestations in at least one third of all diabetics. The skin involvement may be the first presenting sign of diabetes, thus the respective skin signs should lead to diabetes focused diagnostic. Besides, the skin signs may be considered as a marker for the course of the disease or for the success of therapeutic interventions.

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Section: Skin Complications Due To Therapy Of Diabetesmentioning

confidence: 99%

Section: Cutaneous Reactions To Oral Antidiabetic Agentsmentioning

confidence: 99%

Skin signs in diabetes mellitus

Behm

Schreml

Landthaler

et al. 2012

Acad Dermatol Venereol

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“…7 In another case patient developed palpable purpura with metformin but refused for skin biopsy. 8 In these cases the patient developed reactions few days after consuming metformin and the reaction subsided after stopping the medication. 4,6,7 In few cases reappearance of the reaction after reintroduction of the medicine is seen.…”

Section: Discussionmentioning

confidence: 99%

Hypersensitivity reaction with metformin: a case report

Vashisht

Naidu

Mandal

2019

Int J Basic Clin Pharmacol

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Metformin is a biguanide derivative widely used for treatment of diabetic patients. The most common toxic effects of metformin are gastrointestinal (anorexia, nausea, vomiting, abdominal discomfort and diarrhoea). As with other drugs, allergic reactions can occur with metformin also, but these are very rare. A case of hypersensitivity reaction with metformin was reported in adverse drug monitoring centre. A 59-year-old female, newly diagnosed case of diabetes mellitus II, started on metformin tablet 500 mg twice daily, developed purpuric skin lesions on her arms, legs and back few days after starting the drug. metformin was stopped and patient was put on glimepiride tablet. The lesions slowly started subsiding after stopping metformin.

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“…A case of metformin-induced allergic vasculitis was also reported [61]. Erythematous changes in the groin, thighs and genitals area appeared after introduction of metformin.…”

Section: Cutaneous Adverse Effects Of Metforminmentioning

confidence: 93%

“…Opisano również przypadek alergicznego zapalenia naczyń indukowanego metforminą [61]. Zmiany w postaci rumienia w okolicy pachwin, ud i narządów płciowych pojawiły się po rozpoczęciu stosowania metforminy.…”

Section: Cutaneous Adverse Effects Of Metforminunclassified

Metformin in skin diseases

Kadylak¹,

Polak²,

Wojciechowska³

et al. 2021

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Metformin is the most widely used oral antidiabetic drug in the world. It is the first-line drug in type 2 diabetes, where its inhibiting effect on hepatic glucose production, increasing muscle and adipose tissue insulin sensitivity and reduction of glucose absorption in the gut are used. Many benefits to the skin condition have been reported from using metformin in dermatological diseases such as acne vulgaris, hidradenitis suppurativa, hirsutism as well as reducing the risk of certain skin malignancies and the occurrence of psoriasis. Some adverse effects of metformin have also been reported: rash, skin allergic reactions, drug reaction with eosinophilia and systemic symptoms (DRESS syndrome), bullous pemphigoid, leukocytoclastic vasculitis, nail discoloration with subungual hyperkeratosis. The article is a review of currently available literature on the influence of metformin on the course of various skin diseases and its adverse effects.streszczenie Metformina jest najczęściej stosowanym na świecie doustnym lekiem przeciwcukrzycowym. Stanowi lek pierwszego wyboru w terapii cukrzycy typu 2, gdzie wykorzystywany jest jej efekt hamowania wątrobowej produkcji glukozy, zwiększania insulinowrażliwości mięśni i tkanki tłuszczowej oraz zmniejszania wchłaniania glukozy w jelitach. W piśmiennictwie istnieje wiele doniesień o korzystnym wpływie metforminy na stan skóry w chorobach dermatologicznych, takich jak trądzik zwyczajny, hidradenitis suppurativa, hirsutyzm, a także o redukowaniu ryzyka rozwoju niektórych nowotworów złośliwych skóry oraz wystąpienia łuszczycy. Donoszono także o niepożądanych działaniach metforminy: występowaniu osutek, skórnych reakcji alergicznych, reakcji polekowej z towarzyszącą eozynofilią i objawami ogólnymi (drug rash with eosinophilia and systemic syndrome -DRESS), pemfigoidu pęcherzowego, leukocytoklastycznego zapalenia naczyń, przebarwień paznokci z podpaznokciową hiperkeratozą. Artykuł stanowi przegląd dostępnej literatury dotyczącej wpływu metforminy na przebieg różnych chorób skóry oraz jej działań niepożądanych.

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Metformin allergy

Abstract: Metformin is an important antidiabetic agent that is widely used for diabetic patients. Here, a case of metformin allergy, presenting with skin lesions, is reported.

Cited by 10 publications

References 5 publications

Skin signs in diabetes mellitus

Skin signs in diabetes mellitus

Hypersensitivity reaction with metformin: a case report

Metformin in skin diseases

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