2020
DOI: 10.1016/j.diabres.2020.108183
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Metformin in COVID-19: A possible role beyond diabetes

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Cited by 178 publications
(184 citation statements)
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“…Advanced age is by far the greatest risk factor for COVID-19 fatality independent of underlying comorbidities [4]. This striking fact has led many researchers to speculate whether molecules that target aging itself, called geroprotectors, could be used to combat infections in older people [5,159]. Primarily via its regulation of cellular metabolism, the mammalian target of rapamycin (mTOR) signaling pathway controls several immune functions such as antigen presentation, immune activation, differentiation, and cytokine production [160,161].…”
Section: Geroprotectors To Improve Immunitymentioning
confidence: 99%
“…Advanced age is by far the greatest risk factor for COVID-19 fatality independent of underlying comorbidities [4]. This striking fact has led many researchers to speculate whether molecules that target aging itself, called geroprotectors, could be used to combat infections in older people [5,159]. Primarily via its regulation of cellular metabolism, the mammalian target of rapamycin (mTOR) signaling pathway controls several immune functions such as antigen presentation, immune activation, differentiation, and cytokine production [160,161].…”
Section: Geroprotectors To Improve Immunitymentioning
confidence: 99%
“…The increased risk associated with insulin was probably due to the fact that the use of this pharmacotherapy reflects more advanced diabetes disease in patients who are often older and more frail [44]. The possible protective role of metformin has been proposed based on theoretical grounds, and the pleiotropic effects of the compound have yet to be investigated in clinical practice [45]. Of note in CORONADO, however, fewer of the people who died were using metformin.…”
Section: Role Of Antihypertensive and Antidiabetic Medicationsmentioning
confidence: 99%
“…Metformin, the first-line therapy for T2DM with undisputed efficacy and safety and additional antineoplastic, antiaging, anti-inflammatory, immunomodulatory, cardio-, neuro-, hepato-, and nephroprotective actions [275,276], has been proposed as a multi-action protection drug candidate for COVID-19 [277][278][279][280][281][282][283], particularly due to its strong systemic reparatory and modulatory mechanisms. While its effects on RAAS seem to be neutral, lung injury can be efficiently prevented and relieved by metformin, specially by the promotion of microvascular repairing actions [284][285][286][287][288][289], and has also exhibited antiviral activity, enhanced lymphocyte B function and enhanced innate immunity [290][291][292][293][294].…”
Section: Of Minor Relevancementioning
confidence: 99%