Metformin Plus Low-Dose Glimeperide Significantly Improves Homeostasis Model Assessment for Insulin Resistance (HOMAIR) and β-Cell Function (HOMAβ-cell) Without Hyperinsulinemia in Patients With Type 2 Diabetes Mellitus

Bermúdez-Pirela, Valmore; Cano, Clímaco; Medina, Mayerlim; Souki, Aida; Lemus, Miguel A; Leal, Elliuz; Seyfi, Hamid; Cano, Raquel; Ciscek, Ana; Bermúdez-Arias, Fernando; Contreras, Freddy; Israili, Zafar H.; Hernández-Hernández, Rafael; Valasco, Manuel

doi:10.1097/01.pap.0000249909.54047.0e

Cited by 29 publications

(14 citation statements)

References 35 publications

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“…The reduction in HOMA‐IR following metformin supplementation could be simply attributed to its effect on fasting insulin rather than fasting glucose concentration. The current result is in accord with Bermúdez‐Pirela et al () report, which showed the improvement of insulin resistance using metformin in combination with glimepiride on the fasting glucose level, HOMA‐IR, HOMA‐β, and glycosylated hemoglobin. Although metformin offered little benefit over vitamin D, and a combination therapy only showed successful improvements of insulin resistance.…”

Section: Discussionsupporting

confidence: 93%

Synergistic actions of vitamin D and metformin on skeletal muscles and insulin resistance of type 2 diabetic rats

Amin

Hussein

Yassa

et al. 2018

Journal Cellular Physiology

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Diabetes Mellitus is a chronic generalized disorder due to insulin insufficiency or resistance. Skeletal muscles represent one of the most important target organs that is affected by insulin signaling. The aim of the current work was to investigate the effect of metformin versus vitamin D (and also simultaneous administration) therapy in type 2 diabetic (T2D) rats on the state of the muscle and insulin sensitivity. Thirty six male rats constituted the animal model and have been divided into five groups: control, Diabetic, Diabetic + Metformin, Diabetic + Vitamin D, Diabetic + Metformin + Vitamin D. Blood samples were taken for biochemical measurements of serum calcium, interleukin-6 (IL-6), Triglycerides (TG), glucose, insulin, and calculation of HOMA-IR, and then rats were sacrificed, dissected for removal of gastrocnemius muscle that is used for both biochemical, histopathological and electron microscopy examination. Oral administration of vitamin D alone or in combination with metformin improved insulin sensitivity in skeletal muscles, and sustained the metabolic complications along with muscle atrophy and inflammation in T2D rats. We demonstrated super-beneficial action on insulin resistance of additional vitamin D therapy in T2DM rats that were insufficiently controlled by metformin alone.

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Section: Discussionsupporting

confidence: 93%

Synergistic actions of vitamin D and metformin on skeletal muscles and insulin resistance of type 2 diabetic rats

Amin

Hussein

Yassa

et al. 2018

Journal Cellular Physiology

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show abstract

“…[34] The combined metformin and glimepiride (at low dose) is superior in the management of IR studied through HOMA with reduction in HOMA-IR. [35] Metformin is known to improve cardiopulmonary performance in patients with high HOMA-IR possibly by favorable effects on endothelial dysfunction. [18]…”

Section: Oral Treatmentmentioning

confidence: 99%

An approach to acanthosis nigricans

Phiske

2014

Indian Dermatol Online J

118

158

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Acanthosis nigricans (AN) is characterized by dark, coarse and thickened skin with a velvety texture, being symmetrically distributed on the neck, the axillae, antecubital and popliteal fossae, and groin folds, histopathologically characterized by papillomatosis and hyperkeratosis of the skin. A high prevalence of AN has been observed recently. Different varieties of AN include benign, obesity associated, syndromic, malignant, acral, unilateral, medication-induced and mixed AN. Diagnosis is largely clinical with histopathology needed only for confirmation. Other investigations needed are fasting lipoprotein profile, fasting glucose, fasting insulin, hemoglobin and alanine aminotransferase for obesity associated AN and radiological investigations (plain radiography, ultrasonography, magnetic resonance imaging/computerized tomography) for malignancy associated AN. The most common treatment modalities include retinoids and metformin.

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“…HOMA of insulin sensitivity and basal β -cell function are calculated as

\begin{matrix} HOMA-IRI = \frac{FPG \times fasting insulin (Fins)}{22.5}, \end{matrix}

see [17]. Assume

\begin{matrix} HOMA β -cell function (HOMA- β) = \frac{20 \times Fins}{(FPG - 3.5)} . \end{matrix}

…”

Section: Methodsmentioning

confidence: 99%

Effects of Glucose Load and Nateglinide Intervention on Endothelial Function and Oxidative Stress

Wang

Guo²,

Zhang³

et al. 2013

Journal of Diabetes Research

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We analysed endothelial function and oxidative stress in patients with abnormal glucose metabolism, the effect of glucose load, and the impact of nateglinide. 109 participants were grouped into newly diagnosed diabetes, prediabetes, and control. Fasting plasma glucose (FPG), postprandial plasma glucose (PPG), glycosylated haemoglobin (HbA1c), and glycated albumin (GA) varied significantly among the study groups (P < 0.01). Nitric oxide (NO) and insulin resistance index (HOMA-IRI) levels were markedly different between the newly diagnosed diabetes and the control (P < 0.01). Glucose loading lowered flow-mediated endothelium-dependent dilation (FMEDD), NO, and superoxide dismutase (SOD) (P < 0.01). Fasting and glucose loading FMEDD, FPG, PPG, HbA1c, and GA were negatively correlated (r = −0.4573, −0.4602, −0.3895, −0.3897, and r = −0.4594, −0.4803, −0.4494, −0.3885; P < 0.01), whereas NO, SOD, and HOMA-β were positively correlated (r = 0.2983, 0.3211, 0.311, and r = 0.1954, 0.361, 0.2569; P < 0.05). After the treatment with nateglinide, significant decreases in FPG, PPG, GA, HbA1C, endothelin-1(ET-1), malondialdehyde (MDA), and HOMA-IRI were observed, whereas FMEDD, NO, and SOD increased (P < 0.01). Thus, the study demonstrated the adverse effect of glucose load on endothelial function and oxidative stress. Nateglinide lowers blood glucose, reduces insulin resistance and oxidative stress, and improves endothelial function in newly diagnosed diabetes.

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Metformin Plus Low-Dose Glimeperide Significantly Improves Homeostasis Model Assessment for Insulin Resistance (HOMAIR) and β-Cell Function (HOMAβ-cell) Without Hyperinsulinemia in Patients With Type 2 Diabetes Mellitus

Cited by 29 publications

References 35 publications

Synergistic actions of vitamin D and metformin on skeletal muscles and insulin resistance of type 2 diabetic rats

Synergistic actions of vitamin D and metformin on skeletal muscles and insulin resistance of type 2 diabetic rats

An approach to acanthosis nigricans

Effects of Glucose Load and Nateglinide Intervention on Endothelial Function and Oxidative Stress

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