Methacrylate-based monolithic layers for planar chromatography of polymers

Maksimova, E. F.; Влах, Е. Г.; Tennikova, Tatiana

doi:10.1016/j.chroma.2010.12.061

Cited by 12 publications

(17 citation statements)

References 33 publications

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“…Besides in miniaturized formats, monoliths are routinely prepared also on analytical scale e.g. high throughput screening (HTS) in the format of in 96‐well plates or tips , in sheet format of several centimeters size but thickness of only several 10 μm used for planar chromatography , in format of conventional analytical columns or short analytical columns in disk format , as well as in large volume formats intended for purification .…”

Section: Introductionmentioning

confidence: 99%

Application of monoliths for bioparticle isolation

Podgornik

Krajnc

2012

J of Separation Science

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Monoliths are today probably the most studied chromatographic supports. There are plethora of publications dealing with different aspects of their preparation, characterization, and applications. The reason for this interest is their inherent properties related to their particular structure, like ease of preparation in various volumes, fast analytics at low pressure and room temperature, and high productivity as a consequence of flow-unaffected properties, especially important for isolation of large biological molecules. Because of that, structure of several monoliths was optimized for analytics and purification of biologic nanoparticles like viruses, virus-like particles (VLPs), cells structures, or even intact cells. In this review, some recent applications of monoliths in the field of bioparticle isolation are described and results are discussed in terms of particular monolith properties.

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Section: Introductionmentioning

confidence: 99%

Application of monoliths for bioparticle isolation

Podgornik

Krajnc

2012

J of Separation Science

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“…Monolithic columns were introduced in the early 1990s [1], and their preparation in tubes for LC and GC was intensively reviewed [2][3][4]. Later, monolithic adsorbents were invented to TLC [5,6]. Monolithic films based on silica gel [5] and organic polymers [6] possess thin, continuous, bi-porous structures cast onto supporting surface.…”

Section: Preparation Of Monolithic Layersmentioning

confidence: 99%

“…Later, monolithic adsorbents were invented to TLC [5,6]. Monolithic films based on silica gel [5] and organic polymers [6] possess thin, continuous, bi-porous structures cast onto supporting surface. These structures do not require any binder to form a stable layer.…”

Section: Preparation Of Monolithic Layersmentioning

confidence: 99%

Recent advances in the preparation of adsorbent layers for thin‐layer chromatography combined with matrix‐assisted laser desorption/ionization mass‐spectrometric detection

Kucherenko

Kanat’eva

Пирогов

et al. 2018

J of Separation Science

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This review is focused on planar chromatography hyphenated with mass-spectrometric detection for analysis of low-molecular-mass solutes. Various kinds of hyphenations are discussed with attention paid to the preparation of thin layer plates suited both for the mass-spectrometric detection of the resolved solutes direct from thin-layer plates and for indirect mass-spectrometric detection of the resolved solutes, performed by scraping, extracting, purifying, and concentrating the analyte from the thin-layer chromatography plate. Plates with monolithic layers are relatively new for thin-layer chromatography but they can successfully be combined with mass-spectrometric technique in a pursuit of comprehensive local sample composition information. Preparation of monolithic layers of different porosity and structure based on organic, inorganic, and composite materials is illustrated together with examples of successful separation and detection of low-molecular-mass solutes by means of matrix-assisted and surface-assisted laser desorption mass spectrometry.

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“…As a result of the mixed polar/non polar groups and ease of preparation/functionalization, methacrylate monoliths have been prepared for a number of different methods of chromatographic separation, such as ion exchange [44], Hydrophilic Interaction Liquid Chromatography (HILIC) [45], and Reverse Phase [38]. This includes application for the separation of proteins and peptides [27], polymer separations [46,47] as well as alkyl benzenes and other small polar molecules [48,49,50]. …”

Section: Methacrylate Polymer Monolithsmentioning

confidence: 99%

Methacrylate Polymer Monoliths for Separation Applications

Groarke

Brabazon

2016

Materials

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This review summarizes the development of methacrylate-based polymer monoliths for separation science applications. An introduction to monoliths is presented, followed by the preparation methods and characteristics specific to methacrylate monoliths. Both traditional chemical based syntheses and emerging additive manufacturing methods are presented along with an analysis of the different types of functional groups, which have been utilized with methacrylate monoliths. The role of methacrylate based porous materials in separation science in industrially important chemical and biological separations are discussed, with particular attention given to the most recent developments and challenges associated with these materials. While these monoliths have been shown to be useful for a wide variety of applications, there is still scope for exerting better control over the porous architectures and chemistries obtained from the different fabrication routes. Conclusions regarding this previous work are drawn and an outlook towards future challenges and potential developments in this vibrant research area are presented. Discussed in particular are the potential of additive manufacturing for the preparation of monolithic structures with pre-defined multi-scale porous morphologies and for the optimization of surface reactive chemistries.

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Methacrylate-based monolithic layers for planar chromatography of polymers

Cited by 12 publications

References 33 publications

Application of monoliths for bioparticle isolation

Application of monoliths for bioparticle isolation

Recent advances in the preparation of adsorbent layers for thin‐layer chromatography combined with matrix‐assisted laser desorption/ionization mass‐spectrometric detection

Methacrylate Polymer Monoliths for Separation Applications

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