2011
DOI: 10.1016/j.brainres.2011.07.013
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Methamphetamine transiently increases the blood–brain barrier permeability in the hippocampus: Role of tight junction proteins and matrix metalloproteinase-9

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Cited by 109 publications
(103 citation statements)
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“…However, METH has been increasingly recognized to impact also the blood-brain-barrier (BBB), causing the release of inflammatory mediators and astrogliosis (Gold et al, 2009;Goncalves et al, 2010;Northrop and Yamamoto, 2012;Ramirez et al, 2009). METH-induced permeability at the BBB level has been consistently reported both in vivo and in vitro (Conant et al, 2011;Martins et al, 2011;Urrutia et al, 2013), as a result of tight junction and cytoskeleton disarrangement (Dietrich, 2009;Kousik et al, 2012;Park et al, 2013). In endothelial cells, METH was also shown to trigger nitric oxide (NO)-mediated transcytosis (Martins et al, 2013).…”
Section: Introduction Methamphetamine (Meth) Is a Powerful Psychostimmentioning
confidence: 99%
“…However, METH has been increasingly recognized to impact also the blood-brain-barrier (BBB), causing the release of inflammatory mediators and astrogliosis (Gold et al, 2009;Goncalves et al, 2010;Northrop and Yamamoto, 2012;Ramirez et al, 2009). METH-induced permeability at the BBB level has been consistently reported both in vivo and in vitro (Conant et al, 2011;Martins et al, 2011;Urrutia et al, 2013), as a result of tight junction and cytoskeleton disarrangement (Dietrich, 2009;Kousik et al, 2012;Park et al, 2013). In endothelial cells, METH was also shown to trigger nitric oxide (NO)-mediated transcytosis (Martins et al, 2013).…”
Section: Introduction Methamphetamine (Meth) Is a Powerful Psychostimmentioning
confidence: 99%
“…METH is increasingly recognized to impact also nonneuronal cells, such as microglia, and astrocytes and the blood-brain-barrier (BBB), causing the release of inflammatory mediators and astrogliosis [1,3,7,8]. The concept of METH-induced damage at the level of the BBB has gained relevance over the last few years, justifying the interest in understanding its consequences at the endothelium [4,9,10].…”
Section: Introductionmentioning
confidence: 99%
“…In mice models, METH was seen to increase permeability and induce massive leakage of macromolecules across the BBB in the cerebral cortex, hippocampus, and other limbic regions [5,6,9]. In vitro, BBB increased permeability after METH exposure was accompanied by a reduction and/or redistribution of the tight junction (TJ) proteins [7,[12][13][14].…”
Section: Introductionmentioning
confidence: 99%
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