Methicillin-resistant Staphylococcus aureus bacteraemia, 2003–2015: Comparative evaluation of changing trends in molecular epidemiology and clinical outcomes of infections

Niek, Wen Kiong; Teh, Cindy Shuan Ju; Idris, Nuryana; Sit, Pik San; Lee, Yee Qing; Thong, Kwai Lin; Ponnampalavanar, Sasheela

doi:10.1016/j.meegid.2020.104567

Cited by 7 publications

(5 citation statements)

References 20 publications

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“…After reviewing the full texts, we excluded other studies according to the eligibility criteria. Twenty studies (4,5,(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27) were included in the final analysis. The process of article selection is shown in Figure 1.…”

Section: Results Of Study Inclusionmentioning

confidence: 99%

Predictors of mortality in adult patients with methicillin-resistant Staphylococcus aureus bloodstream infection: a meta-analysis and systematic review

Ju¹,

Huang²,

Xu³

et al. 2021

Ann Palliat Med

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Background: Cases of methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infection have been increasing. Patients with MRSA bloodstream infection have a poor prognosis and high mortality rate. Identification of potential risk factors associated with MRSA bloodstream infection-related mortality may help improve patient outcomes. Methods: Embase, PubMed, and the Cochrane Library databases were searched to identify articles describing predictors of mortality in patients with MRSA bloodstream infections. Two investigators independently assessed articles for inclusion and data extraction.Results: Twenty observational studies were included in the analysis. Factors associated with higher mortality were development of severe sepsis or septic shock [

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Section: Results Of Study Inclusionmentioning

confidence: 99%

Predictors of mortality in adult patients with methicillin-resistant Staphylococcus aureus bloodstream infection: a meta-analysis and systematic review

Ju¹,

Huang²,

Xu³

et al. 2021

Ann Palliat Med

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“…In our study, the mortality rate due to MRSA bacteremia was 17%. The risk factors for mortality in MRSA bacteremia are age, catheter device use, and exposure to macrolides [25][26][27]. Our study showed that those who died were older than those alive.…”

Section: Plos Onementioning

confidence: 61%

“…Early removal of devices in MRSA bacteremia is important because MRSA forms biofilms, which reduce the effectiveness of antimicrobial agents [37,38]. In addition, catheter-related bacteremia is strongly associated with in-hospital mortality [27].…”

Section: Plos Onementioning

confidence: 99%

Relationship between mortality and molecular epidemiology of methicillin-resistant Staphylococcus aureus bacteremia

et al. 2022

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Staphylococcus aureus is the primary cause of bacteremia, and methicillin-resistant S. aureus bacteremia is associated with a high mortality rate. Methicillin-resistant S. aureus clones are widespread worldwide, and molecular epidemiological studies are important. Therefore, this study aimed to determine the characteristics of patients who died due to methicillin-resistant S. aureus bacteremia and microbiological characteristics of methicillin-resistant S. aureus strains in a tertiary teaching hospital. This single-center, retrospective study included patients with methicillin-resistant S. aureus isolated from blood bacterial culture performed at Kyoto Prefectural University of Medicine Hospital, from October 2016 to May 2019. The data analyzed included patient background, clinical strain characteristics, and molecular epidemiology. Of 41 patients with methicillin-resistant S. aureus bacteremia (median age, 60 [28–70] years; 24 (59%) were men), and 7 (17%) died due to methicillin-resistant S. aureus bacteremia. The median age of those who died in the methicillin-resistant S. aureus bacteremia group was predominantly higher than that of those in the alive group (p = 0.03). The most common cause of methicillin-resistant S. aureus bacteremia was endovascular devices, which occurred in 20 (49%), 18 (53%), and 2 (29%) patients in the total, alive, and died groups, respectively. Bacteriological characteristics showed that type IV Staphylococcal Cassette Chromosome mec genotype was most frequently detected in the total (n = 34 [83%]), alive (n = 29 [85%]), and died (n = 5 [71%]) groups. In the molecular cluster analysis, CC8, ST8, staphylococcal Cassette Chromosome mec type IV, and community-acquired-methicillin-resistant S. aureus formed the largest groups. The diversity of methicillin-resistant S. aureus clones is evident, and it is possible that clones with new virulence factors may still emerge. In the future, it will be crucial to monitor the epidemiological trends of methicillin-resistant S. aureus to respond quickly to changes in pathogenic and clonal factors, to clarify the gene expression network by identifying old and new virulence factors.

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“…Staphylococcus aureus resistentes a meticilina (MRSA) son los patógenos predominantes causantes de infecciones invasivas tales como las bacteriemias (Niek et al, 2020). Con datos obtenidos en 2018, en-viados al Centro Europeo de Vigilancia de la Resistencia Antimicrobiana (EARS-Net), provenientes de 30 países de la Unión Europea y de la Comunidad Económica Europea, el porcentaje de MRSA ha venido a la baja, sin embargo, los niveles en Europa siguen siendo muy elevados en algunos países; oscilando entre el 1,0% en Noruega y el 44,4% en Rumanía, con una media ponderada por población del 16,9% (ECDC, 2018).…”

Section: Impacto De Las Infecciones Por Staphylococcus Aureus Multidr...unclassified

Staphylococcus aureus y Streptococcus pneumoniae: INFECCIONES NOSOCOMIALES QUE REPRESENTAN UNA AMENAZA APREMIANTE PARA LA SALUD PúBLICA

Morales,

Tapia,

Baez

et al. 2022

RDIC

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Los antibióticos son un grupo de medicamentos que son utilizados para el control de infecciones causadas por bacterias y parásitos. La resistencia a los antibióticos es originada por un mal uso en el tratamiento de las infecciones, y se produce cuando los microorganismos logran adaptarse y crecer en presencia de medicamentos que alguna vez los impactaron. El débil control en la utilización de estos agentes ha propiciado que en la naturaleza se distribuyan organismos resistentes a los antimicrobianos prescritos popularmente, lo cual se ha convertido en un problema de salud pública. La infección por microorganismos resistentes a diferentes compuestos antimicrobianos conduce a enfermedades graves, ingresos hospitalarios prolongados, aumento en los costos de atención médica y en medicamentos de segunda línea, y fracasos en los tratamientos. Uno de los patógenos del cual se ha descrito una alta incidencia en infecciones nosocomiales, identificado como multidrogorresistentes, de mal pronóstico en pacientes inmunosuprimidos, es Staphylococcus aureus, el cual se caracteriza por ser la principal causa de bacteriemia nosocomial. Otro de los principales patógenos responsables de muchos de los casos de neumonía reportados en niños y adultos es Streptococcus pneumoniae. La información sobre los diferentes mecanismos de resistencia permite recalcar la urgencia e importancia de encontrar nuevas alternativas terapéuticas para combatir las infecciones nosocomiales. La generación y propagación de cepas multidrogorresistentes debe prevenirse mediante restricciones severas en el uso de los antibióticos, respetando la prescripción, incluyendo el número de dosis y el periodo de tiempo de su ingesta, así como evitando la automedicación.

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Methicillin-resistant Staphylococcus aureus bacteraemia, 2003–2015: Comparative evaluation of changing trends in molecular epidemiology and clinical outcomes of infections

Cited by 7 publications

References 20 publications

Predictors of mortality in adult patients with methicillin-resistant Staphylococcus aureus bloodstream infection: a meta-analysis and systematic review

Predictors of mortality in adult patients with methicillin-resistant Staphylococcus aureus bloodstream infection: a meta-analysis and systematic review

Relationship between mortality and molecular epidemiology of methicillin-resistant Staphylococcus aureus bacteremia

Staphylococcus aureus y Streptococcus pneumoniae: INFECCIONES NOSOCOMIALES QUE REPRESENTAN UNA AMENAZA APREMIANTE PARA LA SALUD PúBLICA

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