Methicillin resistant Staphylococcus aureus liver abscess related with colorectal cancer

Lezcano-Gort, Luis Enrique; Calderón-Pecellín, Alba; Antón-Martínez, Joaquín

doi:10.4321/s1130-01082013000900014

Cited by 3 publications

(1 citation statement)

References 2 publications

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“…Most of the case reports on MRSA liver abscesses are associated with underlying risk factors which include hepatobiliary and colonic pathologies, liver trauma, frequent hospitalization, and surgical procedures (Table 1) [7][8][9][10][11]. Upon literary search, we were able to find one case with a similar presentation as our patient that was reported in India [3].…”

Section: Discussionmentioning

confidence: 68%

Unusual Liver Mass in an Immunocompetent Adult: A Case Report and Literature Review

Dessie¹,

Dahshan²,

Singh³

et al. 2020

Cureus

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Section: Discussionmentioning

confidence: 68%

Unusual Liver Mass in an Immunocompetent Adult: A Case Report and Literature Review

Dessie¹,

Dahshan²,

Singh³

et al. 2020

Cureus

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Forkhead Box O1 Regulates Macrophage Polarization Following Staphylococcus aureus Infection: Experimental Murine Data and Review of the Literature

Wang

Yin

et al. 2016

Clinic Rev Allerg Immunol

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The functions of macrophages that lead to effective host responses are critical for protection against Staphylococcus aureus. Deep tissue-invading S. aureus initially countered by macrophages trigger macrophage accumulation and induce inflammatory responses through surface receptors, especially toll-like receptor 2 (TLR2). Here, we found that macrophages formed sporadic aggregates in the liver during infection. Within those aggregates, macrophages co-localized with T cells and were indispensable for their infiltration. In addition, we have focused on the mechanisms underlying the polarization of macrophages in Forkhead box transcription factor O1 (FoxO1) conditional knockout Lys FoxO1 mice following S. aureus infection and report herein that macrophage M1-M2 polarization via TLR2 is intrinsically regulated by FoxO1. Indeed, for effective FoxO1 activity, stimulation of TLR2 is essential. However, following S. aureus challenge, there was a decrease in macrophage FoxO1, with increased phosphorylation of FoxO1 because of TLR2-mediated activation of PI3K/Akt and c-Raf/MEK/ERK pathway. Following infection in Lys FoxO1 mice, mice became more susceptible to S. aureus with reduced macrophage aggregation in the liver and attenuated Th1 and Th17 responses. FoxO1 abrogation reduced M1 pro-inflammatory responses triggered by S. aureus and enhanced M2 polarization in macrophages. In contrast, overexpression of FoxO1 in macrophages increased pro-inflammatory mediators and functional surface molecule expression. In conclusion, macrophage FoxO1 is critical to promote M1 polarization and maintain a competent T cell immune response against S. aureus infection in the liver. FoxO1 regulates macrophage M1-M2 polarization downstream of TLR2 dynamically through phosphorylation.

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Bacterial and Miscellaneous Infections of the Liver

Zangeneh¹,

Ramahi²,

Klotz³

2018

Zakim and Boyer's Hepatology

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Methicillin resistant Staphylococcus aureus liver abscess related with colorectal cancer

Cited by 3 publications

References 2 publications

Unusual Liver Mass in an Immunocompetent Adult: A Case Report and Literature Review

Unusual Liver Mass in an Immunocompetent Adult: A Case Report and Literature Review

Forkhead Box O1 Regulates Macrophage Polarization Following Staphylococcus aureus Infection: Experimental Murine Data and Review of the Literature

Bacterial and Miscellaneous Infections of the Liver

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