Methisoprinol as an immunomodulator for treating infectious mononucleosis

Abstract

Background: Infectious mononucleosis (IM) is the self limiting disease that associated with primary Epstein Barr virus (EBV). It is a gamma herpes virus. EBV infection is follows saliva-transfer by kissing or sexual intercourse. The most clinical manifestation in IM consists mainly of the specific sign: pharyngitis, fever, and lymphadenopathy. The main therapy is supportive treatment. Actually the antiviral therapy is required for the host with high response immune. Purpose: The aimed of this study was to report the therapy of IM using methisoprinol. Case: The woman patient, 33 years old, came to hospital by suffering pharyngitis and swolen on left neck. It had been since 3 days ago. Case management: She had come to Puskesmas that were given amoxycillin capsul 500 mg three times a day for three days and paracetamol tablet 500mg three times a day for three days, but she was still ill. Then she came to RSGM Hasan Aman Banjarmasin. She was diagnosed as IM. The instruction were isolation and bed rest for a week. She had to eat sofly and drink water highly. The therapy were amoxycillin capsul 500 mg three times a day for seven days, methisoprinol caplet 500 mg three times a day for seven days, natrium dikofenak tablet 50 mg three times a day for seven days. She was asked to see the dentist next 7 days. In this case, she were not given acyclovir. Conclusion: IM is self limiting disease. IM is the disease with spesific clinical syndrome that associated with primary EBV infection. Depend on the base of clinical experiences, the supportive treatment is adviced for patient of IM. Methisoprinol has both immunomodulator and antiviral properties.

Management of herpangina: a viral infection in infants

“…It helps the body to fight infection and is recommended to be taken even though the condition has improved to avoid reinfection. 23 Adequate fluid intake may prevent dehydration from painful oral lesions. Cold liquids are usually preferred.…”

The different symptoms determining management of hand foot and mouth disease and primary varicella zoster infection

“…Methisoprinol can be prescribed during the onset of the disease as a prophylaxis against reactivation of latent Varicella zoster infection. 12,14 The etiology of HFMD is Enterovirus 71 or Coxsackie virus, both of which constitute RNA viruses. The case reported here indicated that HFMD can be treated with methisoprinol which contains an antiviral and immunomodulator agent, as opposed to acyclovir, because HFMD is not a herpes virus.…”

“…It can modulate T-lymphocyte and natural killer cell cytotoxicity, T4 helper and T8 suppressor cell functions. 14,15 Based on the foregoing discussion, it can be concluded that a dentist is responsible for detecting specific clinical symptoms of a disease to distinguish HFMD and Primary varicella zoster infection. Although these diseases share similar clinical symptoms, they have contrasting etiologies which require different treatment.…”

The management of herpes labialis, oral thrush and angular cheilitis in cases of oral diabetes

“…He was prescribed acyclovir which can prevent virus replication through three mechanisms: phosphorylation of acyclovir to phosphate derivates within the cell via viral thymidine kinase, inhibition of DNA polymerase by acyclovir activation, and termination of chain elongation by eliminating cyclic sugar from acyclovir triphosphate. 12 Acceleration of the wound healing process and prevention of secondary infection in herpes labialis were managed by prescribing topical alloclair to be gargled and topical application to the lower lip region. Due to its aloevera extract content, aloclair can accelerate wound healing through stimulation of and increase in anti-inflammatory cell activity which enhances the reepithelization process.…”