The formation and development of the waste processing industry is important in the social and economic life of society. Ensuring environmental safety, rational nature management and minimizing the negative impact of waste on the environment are priority areas for the development of the Voronezh region. Currently, the regional system for managing municipal solid waste is being modernized through the formation of inter-municipal environmental waste processing clusters (IEWC). In this regard, the need to study the issue of assessing the effectiveness of ongoing measures to form an integrated infrastructure for safe waste management is very relevant, especially in the context of digitalization. The analysis of the system of target indicators of the federal and regional levels for the disposal, disposal and disposal of waste. As a result of the study, it was concluded that environmental indicators prevail in the management system in the field of safe waste management. The team of authors examined the variety of properties and characteristics of socio-ecological clusters and, on the basis of a comparative analysis, highlighted criteria by which it is possible to assess the results of digital transformation and the efficiency of the functioning of the sphere of safe waste management in our region. Using the results of this study will make it possible to analyze and control the degree of achievement of the objectives of the regional program for the modernization of the waste management sector in order to make effective management decisions in the context of digital transformation.