Subject. This article considers the region as a dynamic system.
Objectives. The article aims to group the regions of Russia according to the level of stability and determine the prospects for the economic development of these groups from the systems theory point of view.
Methods. For the study, we used the methods of logical, cluster, comparative, correlation and regression analyses.
Results. The article divides the regions of Russia into six groups (virtual clusters) depending on the level of socio-ecological-economic stability. A reduction in the average life expectancy of the population should be considered as a general indicator characterizing the low level of stability.
Conclusions. A decrease in the number of students in universities, a decrease in the level of employment, as well as environmental problems pose a threat in the strategic perspective for the regions of Russia characterized by a low level of sustainability.