Methodology for Rapid Isolation of Moringin: Potential Anticancer Compound from the Seeds of Moringa stenopetala

Habtemariam, Solomon

doi:10.4172/2153-2435.1000558

Cited by 12 publications

(10 citation statements)

References 40 publications

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“…M. stenopetala contains alkaloids, amino acids, essential oils, fatty acids, flavonoids, phenolic compounds, and sterols [ 55 ]. Some pharmacological activities of M. stenopetala have been reported in the literature including antimicrobial [ 56 – 58 ], antidiabetic [ 59 – 61 ], antitrypanosomal [ 62 ], antimalarial [ 63 ], anti-Leishmania [ 64 ], anti-inflammatory and analgesic [ 65 , 66 ], antihypertensive [ 67 ], antioxidant [ 61 , 68 , 69 ], anticancer [ 70 ], and thyroid function [ 71 ]. It could be more effective than other antihypertensive medicinal plants in terms of treatment.…”

Section: Resultsmentioning

confidence: 99%

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Traditional Herbal Remedies in the Management of Metabolic Disorders in Ethiopia: A Systematic Review of Ethnobotanical Studies and Pharmacological Activities

Tola

Ibrahim

Melak

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Background. MetS are common throughout the world, including Ethiopia. These have traditionally been treated using medicinal plants, particularly in rural areas where they are freely accessible. This systematic review tried to investigate the treatment of MetS with Ethiopian medicinal herbs and made recommendations for more validation research. A careful analysis of the literature was also conducted on the therapeutic effects of these and other Ethiopian medicinal plants with hepatoprotective and antihypertensive activities. Methods. The relevant keywords “Ethnomedicinal + hypertension,” “Ethnopharmacological + hypertension,” “Ethnomedicinal + hepatitis, jaundices, and liver disease,” “Ethnopharmacological + hepatic disorder,” and “Ethnomedicinal + weight loss” were used to search for relevant articles in the major electronic scientific databases, including PubMed, Science Direct, Web of Science, and Google Scholar. The search strategy included all articles with descriptions that were accessible until April 30, 2022. The study’s subjects, methods, or year of publication were no restrictions in the search. The outcomes were compiled using descriptive statistics. Results. Fifty-four (54) studies were examined in the review that satisfied the inclusion and exclusion criteria for the treatment of MetS in Ethiopia. The most often used ethnobotanical plant species for the treatment of hypertension and hepatic disorders were Moringa stenopetala and Croton macrostachyus. Both hepatic and hypertensive disorders were treated more frequently with leaves (52% and 39%, respectively) than with roots (20% and 13%, respectively). Some intriguing studies came from an ethnobotanical investigation into medicinal herbs’ hepatoprotective and antihypertensive properties. The most often investigated medicinal plant for its antihypertensive effects is Moringa stenopetala. Conclusion. The study revealed that Ethiopians often use anti-MetS herbal remedies. We advocate the experimental validation of the commonly used medicinal plants with the identification of active compounds and the development of effective alternative drugs for the treatment of MetS.

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Section: Resultsmentioning

confidence: 99%

“…Evidence-Based Complementary and Alternative Medicine [64], anti-infammatory and analgesic [65,66], antihypertensive [67], antioxidant [61,68,69], anticancer [70], and thyroid function [71]. It could be more efective than other antihypertensive medicinal plants in terms of treatment.…”

Section: Simaroubaceaementioning

confidence: 99%

Traditional Herbal Remedies in the Management of Metabolic Disorders in Ethiopia: A Systematic Review of Ethnobotanical Studies and Pharmacological Activities

Tola

Ibrahim

Melak

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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“…peel, pulp, and seeds [14] and phenethyl ITC from watercress (Nasturtium officinale) [15]. The sugar derivatives of hydroxybenzyl ITC are represented by moringin, isolated from Moringa oleifera and M. stenopetala [16]. Removing the gl unit from glucosinolates by myrosinase leads to the unstable aglucon, meaning that thiohyd mate-O-sulphate is released.…”

Section: Overview Of Chemistry and Biological Relevancementioning

confidence: 99%

Anti-Inflammatory Therapeutic Mechanisms of Isothiocyanates: Insights from Sulforaphane

Habtemariam

2024

Biomedicines

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Isothiocyanates (ITCs) belong to a group of natural products that possess a highly reactive electrophilic -N=C=S functional group. They are stored in plants as precursor molecules, glucosinolates, which are processed by the tyrosinase enzyme upon plant tissue damage to release ITCs, along with other products. Isolated from broccoli, sulforaphane is by far the most studied antioxidant ITC, acting primarily through the induction of a transcription factor, the nuclear factor erythroid 2–related factor 2 (Nrf2), which upregulates downstream antioxidant genes/proteins. Paradoxically, sulforaphane, as a pro-oxidant compound, can also increase the levels of reactive oxygen species, a mechanism which is attributed to its anticancer effect. Beyond highlighting the common pro-oxidant and antioxidant effects of sulforaphane, the present paper was designed to assess the diverse anti-inflammatory mechanisms reported to date using a variety of in vitro and in vivo experimental models. Sulforaphane downregulates the expression of pro-inflammatory cytokines, chemokines, adhesion molecules, cycloxyhenase-2, and inducible nitric oxide synthase. The signalling pathways of nuclear factor κB, activator protein 1, sirtuins 1, silent information regulator sirtuin 1 and 3, and microRNAs are among those affected by sulforaphane. These anti-inflammatory actions are sometimes due to direct action via interaction with the sulfhydryl structural moiety of cysteine residues in enzymes/proteins. The following are among the topics discussed in this paper: paradoxical signalling pathways such as the immunosuppressant or immunostimulant mechanisms; crosstalk between the oxidative and inflammatory pathways; and effects dependent on health and disease states.

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“…The diminished intracellular level of GSH is therefore the hallmark of cell death induced by ROS-activating agents. Thus, drugs that deplete GSH, such as plant isothiocyanates (e.g., moringin), do also have a potent anticancer effect [ 169 ]. Whether the α,β-unsaturated carbonyl moiety in genipin/geniposide discussed in Section 4.1 directly interacts with sensitive thiol groups to account for the diminished antioxidant (GSH) status remains to be proved.…”

Section: Lessons On the Mechanisms Of Actionmentioning

confidence: 99%

Plant-Derived Anticancer Agents: Lessons from the Pharmacology of Geniposide and Its Aglycone, Genipin

Habtemariam

Lentini

2018

Biomedicines

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For centuries, plants have been exploited by mankind as sources of numerous cancer chemotherapeutic agents. Good examples of anticancer compounds of clinical significance today include the taxanes (e.g., taxol), vincristine, vinblastine, and the podophyllotoxin analogues that all trace their origin to higher plants. While all these drugs, along with the various other available therapeutic options, brought some relief in cancer management, a real breakthrough or cure has not yet been achieved. This critical review is a reflection on the lessons learnt from decades of research on the iridoid glycoside geniposide and its aglycone, genipin, which are currently used as gold standard reference compounds in cancer studies. Their effects on tumour development (carcinogenesis), cancer cell survival, and death, with particular emphasis on their mechanisms of actions, are discussed. Particular attention is also given to mechanisms related to the dual pro-oxidant and antioxidant effects of these compounds, the mitochondrial mechanism of cancer cell killing through reactive oxygen species (ROS), including that generated through the uncoupling protein-2 (UCP-2), the inflammatory mechanism, and cell cycle regulation. The implications of various studies for the evaluation of glycosidic and aglycone forms of natural products in vitro and in vivo through pharmacokinetic scrutiny are also addressed.

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Methodology for Rapid Isolation of Moringin: Potential Anticancer Compound from the Seeds of Moringa stenopetala

Cited by 12 publications

References 40 publications

Traditional Herbal Remedies in the Management of Metabolic Disorders in Ethiopia: A Systematic Review of Ethnobotanical Studies and Pharmacological Activities

Traditional Herbal Remedies in the Management of Metabolic Disorders in Ethiopia: A Systematic Review of Ethnobotanical Studies and Pharmacological Activities

Anti-Inflammatory Therapeutic Mechanisms of Isothiocyanates: Insights from Sulforaphane

Plant-Derived Anticancer Agents: Lessons from the Pharmacology of Geniposide and Its Aglycone, Genipin

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