Methodology on quantification of sonication duration for safe application of MR guided focused ultrasound for liver tumour ablation

Mihçin, Şenay; Karakitsios, Ioannis; Le, Nhan; Strehlow, Jan; Demedts, Daniel; Schwenke, Michael; Haase, Sabrina; Preußer, Tobias; Melzer, Andreas

doi:10.1016/j.cmpb.2017.09.006

Cited by 4 publications

(1 citation statement)

References 7 publications

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“…The TRANS-FUSIMO treatment system (TTS) is intended for the focused ultrasound treatment of upper abdominal organs such as the liver [ 72 ]. HIFU treatment of upper abdominal areas can be challenging due to respiration motion and the presence of occluding structures (e.g., ribcage) that attenuates and reflects the ultrasound energy.…”

Section: Mri-guided Hifu Systemsmentioning

confidence: 99%

Review of Robot-Assisted HIFU Therapy

Gunderman

Montayre

Ranjan

et al. 2023

Sensors

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This paper provides an overview of current robot-assisted high-intensity focused ultrasound (HIFU) systems for image-guided therapies. HIFU is a minimally invasive technique that relies on the thermo-mechanical effects of focused ultrasound waves to perform clinical treatments, such as tumor ablation, mild hyperthermia adjuvant to radiation or chemotherapy, vein occlusion, and many others. HIFU is typically performed under ultrasound (USgHIFU) or magnetic resonance imaging guidance (MRgHIFU), which provide intra-operative monitoring of treatment outcomes. Robot-assisted HIFU probe manipulation provides precise HIFU focal control to avoid damage to surrounding sensitive anatomy, such as blood vessels, nerve bundles, or adjacent organs. These clinical and technical benefits have promoted the rapid adoption of robot-assisted HIFU in the past several decades. This paper aims to present the recent developments of robot-assisted HIFU by summarizing the key features and clinical applications of each system. The paper concludes with a comparison and discussion of future perspectives on robot-assisted HIFU.

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Section: Mri-guided Hifu Systemsmentioning

confidence: 99%

Review of Robot-Assisted HIFU Therapy

Gunderman

Montayre

Ranjan

et al. 2023

Sensors

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Advanced software for MRgFUS treatment planning

Filippou

Georgiou

Nikolaou

et al. 2023

Computer Methods and Programs in Biomedicine

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MR-guided focused ultrasound application for moving target tumor ablation in abdominal area: coil selection

et al. 2020

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Background Magnetic Resonance Imaging (MRI)-guided Focused Ultrasound Surgery (MRgFUS) is a non-invasive thermal ablation method utilizing high-intensity focused ultrasound (HI-FU) energy for tissue ablation under MRI with real-time thermal mapping. Ablating to a dynamic target as in the liver is very challenging, requiring approval. A novel quality-assured liver tumor ablation system has been proposed for clinics. The paper reports the evaluation of conventional and new MR-receiving coils. Purpose To evaluate the suitability of MR coils as part of the MRgFUS treatment system for liver, while simulating breathing motion in pre-clinical settings. Material and Methods The novel software communicates with the MR scanner and the transducer. To monitor the temperature via proton resonance frequency (PRF) methodology echo planar imaging (EPI) sequence was used while the algorithms of static, static and dynamic tracking were tested with sonications of 100 W for 30 s on tissue-mimicking phantoms. Different coil sets were used to assess the performance of the system for fitness for dynamic thermometry. Finally, in vivo experiments were performed over a porcine model. Results Single-loop four-channel Duoflex and Gem coils provided adequate signal-to-noise ratio and contrast with consistent thermal readings. Body array coils showed severe loss of signal in dynamic cases since the integration of tracking algorithm causes low efficiency. Conclusion Body array coils are unsuitable for MRgFUS of the liver due to signal loss. The dedicated coil set with a single loop around the FUS transducer combined with four-channel arrays might be the best option for liver treatment using dynamic MRgFUS applications.

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Methodology on quantification of sonication duration for safe application of MR guided focused ultrasound for liver tumour ablation

Abstract: The evidence obtained via this protocol is crucial for translation- of-research into the clinics for safe application of MRgFUS. The developed protocol could be used for system maintenance in compliance with quality systems in clinics for daily quality assurance routines.

Cited by 4 publications

References 7 publications

Review of Robot-Assisted HIFU Therapy

Review of Robot-Assisted HIFU Therapy

Advanced software for MRgFUS treatment planning

MR-guided focused ultrasound application for moving target tumor ablation in abdominal area: coil selection

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