Methods for bladder cancer diagnosis – The role of autofluorescence and photodynamic diagnosis

Bochenek, Kamil; Aebisher, David; Międzybrodzka, Anna; Cieślar, Grzegorz; Kawczyk‐Krupka, Aleksandra

doi:10.1016/j.pdpdt.2019.05.036

Cited by 26 publications

(25 citation statements)

References 52 publications

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“…Bladder cancer sits at the 9th position in cancer types' commonality and is one of the common cancer in humans ( 127 ). It is a multifaceted disease linked to increased morbidity and mortality when left untreated ( 128 ).…”

Section: Bladder Cancermentioning

confidence: 99%

Urolithins: The Gut Based Polyphenol Metabolites of Ellagitannins in Cancer Prevention, a Review

et al. 2021

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Cancer as a disease continues to ravage the world population without regard to sex, age, and race. Due to the growing number of cases worldwide, cancer exerts a significant negative impact on global health and the economy. Interestingly, chemotherapy has been used over the years as a therapeutic intervention against cancer. However, high cost, resistance, and toxic by-effects to treatment have overshadowed some of its benefits. In recent times, efforts have been ongoing in searching for anticancer therapeutics of plant origin, focusing on polyphenols. Urolithins are secondary polyphenol metabolites derived from the gut microbial action on ellagitannins and ellagic acid-rich foods such as pomegranate, berries, and nuts. Urolithins are emerging as a new class of anticancer compounds that can mediate their cancer-preventive activities through cell cycle arrest, aromatase inhibition, induction of apoptosis, tumor suppression, promotion of autophagy, and senescence, transcriptional regulation of oncogenes, and growth factor receptors. In this review, we discussed the growing shreds of evidence supporting these secondary phenolic metabolites' anticancer properties. Furthermore, we have pointed out some of the future directions needed to establish urolithins as anticancer agents.

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Section: Bladder Cancermentioning

confidence: 99%

Urolithins: The Gut Based Polyphenol Metabolites of Ellagitannins in Cancer Prevention, a Review

et al. 2021

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“…23 Fluorescence cystoscopy using PPD can detect neoplastic and pre-cancerous lesions among areas of healthy tissue, allowing more accurate sampling for histopathological examination and enabling removal of the tumor with an appropriate safety margin. 25 In the current study, the overall sensitivity of PDD was 91.3%. This is compatible with the results of previous studies that reported a range from 92% to 100 %.…”

Section: Discussionmentioning

confidence: 45%

Comparative study of screening techniques used in early detection of urinary bladder cancer

Abbas¹

2019

UNOAJ

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Background: Early detection of urinary bladder cancer can help improve patients' outcomes. Detection and follow-up for recurrence by cystoscopy and histopathology of obtained biopsies is costly and causes discomfort to patients. There is a need to find sensitive, specific screening techniques as alternatives to reduce the frequency or to improve the sensitivity for detection of early bladder cancer. Objective: This study aimed to compare bladder washing cytology (BWC), bladder tumor antigen (BTA), flowcytometry (FCM), and photodynamic diagnosis (PDD) for early detection of urinary bladder cancer. Methods: This prospective cohort study was conducted on 75 patients with hematuria/ cystitis or previous resection of bladder cancer. The four diagnostic techniques were performed in every patient. The results of the studied techniques were compared to the histopathological findings in these patients. Sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) were calculated. Results: The BWC and PDD showed the highest accuracy (each was 77.3%). The PPD technique had the highest sensitivity and NPV (91.3% and 94.9%, respectively), while the BWC had the highest specificity and PPV (92.3% and 71.4%, respectively). Sensitivity was higher in high grade tumors than the low grades in BWC, while sensitivity was higher in the low-grade tumors than the high grades in the other techniques. Conclusions: The BWC and PDD had the highest accuracy for detection of bladder cancer. Their combined use is recommended to obtain high sensitivity and specificity.

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“…The images are analyzed and are presented as a single real-time image on a monitor. Researchers have proposed algorithms that increase the effectiveness of detecting abnormal tissue, especially dysplastic and neoplastic, but also inflammed tissue in pulmonology, gastrology, and urology [ 24 , 25 ]. High-fluorescence fields are interlaced with low-fluorescence areas that are close to normal, or clearly lower, and correlated with the NCV index [ 26 , 27 , 28 , 29 ].…”

Section: Methodsmentioning

confidence: 99%

Photodynamic Therapy for the Treatment of Infected Leg Ulcers—A Pilot Study

et al. 2021

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Chronic and infected leg ulcers (LUs) are painful, debilitating, resistant to antibiotics, and immensely reduce a patient’s quality of life. The purpose of our study was to demonstrate the efficacy of photodynamic therapy (PDT) for the treatment of infected chronic LUs. Patients were randomized into two experimental groups: the first group received 5-aminolevulinic acid photodynamic therapy (ALA-PDT) (10 patients), and the second group of 10 patients received local octenidine dihydrochloride (Octenilin gel) exposed to a placebo light source with an inserted filter that mimiced red light. In the PDT group, we used 20% ALA topically applied for 4 hrs and irradiation from a Diomed laser source with a wavelength of 630 nm at a fluency of 80 J/cm2. ALA-PDT was performed 10 times during a 14-day hospitalization in 10 patients of both sexes aged 40–85 years with chronic leg ulcers. Treatments were carried out at 3-week intervals for 3–5 cycles. At 8-month follow-up with the PDT group, complete remission (CR) was obtained in four patients (40%), partial response (>50% reduction in ulcer diameter) in four patients (40%), and no response in two patients (20%) who additionally developed deterioration of the local condition with swelling, erythema, and inflammation. To assess the degree of pain during the trials, we used a numeric rating scale (NRS). From the preliminary results obtained, we concluded that PDT can be used to treat leg ulcers as a minimally invasive and effective method with no serious side effects, although further studies on a larger group of patients with LUs are warranted.

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Methods for bladder cancer diagnosis – The role of autofluorescence and photodynamic diagnosis

Cited by 26 publications

References 52 publications

Urolithins: The Gut Based Polyphenol Metabolites of Ellagitannins in Cancer Prevention, a Review

Urolithins: The Gut Based Polyphenol Metabolites of Ellagitannins in Cancer Prevention, a Review

Comparative study of screening techniques used in early detection of urinary bladder cancer

Photodynamic Therapy for the Treatment of Infected Leg Ulcers—A Pilot Study

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