Methods for Engineering of Multicellular Spheroids to Reconstitute the Liver Tissue

Kojima, Naoya; Tao, Fumiya; Mihara, Hirotaka; Aoki, Shigehisa

doi:10.1016/b978-0-12-812301-0.00008-6

Cited by 5 publications

(2 citation statements)

References 14 publications

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“…6,7 Because of its biocompatibility, it is a popular crowding agent in cell research. [8][9][10] Recently, MC was employed in microfluidic cell mechanical measurements because of its ability to increase the cell carrier viscosity already at small concentrations while maintaining cell viability. An increased viscosity reduces cell sedimentation during the experiments and increases the hydrodynamic shear stresses that act on the cell surface to deform them, which is often desirable.…”

Section: Introductionmentioning

confidence: 99%

Shear rheology of methyl cellulose based solutions for cell mechanical measurements at high shear rates

et al. 2023

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Section: Introductionmentioning

confidence: 99%

Shear rheology of methyl cellulose based solutions for cell mechanical measurements at high shear rates

et al. 2023

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“…Methylcellulose has low reactivity with cells. Additionally, interest has been shown in mixing it with biologically active materials such as cytokines and/or the extracellular matrix to control the organization or functions of the cells [91].…”

Section: Methylcellulosementioning

confidence: 99%

Intravitreal Injectable Hydrogels for Sustained Drug Delivery in Glaucoma Treatment and Therapy

Akulo¹,

Adalı

Moyo³

et al. 2022

Polymers

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Glaucoma is extensively treated with topical eye drops containing drugs. However, the retention time of the loaded drugs and the in vivo bioavailability of the drugs are highly influenced before reaching the targeted area sufficiently, due to physiological and anatomical barriers of the eye, such as rapid nasolacrimal drainage. Poor intraocular penetration and frequent administration may also cause ocular cytotoxicity. A novel approach to overcome these drawbacks is the use of injectable hydrogels administered intravitreously for sustained drug delivery to the target site. These injectable hydrogels are used as nanocarriers to intimately interact with specific diseased ocular tissues to increase the therapeutic efficacy and drug bioavailability of the anti-glaucomic drugs. The human eye is very delicate, and is sensitive to contact with any foreign body material. However, natural biopolymers are non-reactive, biocompatible, biodegradable, and lack immunogenic and inflammatory responses to the host whenever they are incorporated in drug delivery systems. These favorable biomaterial properties have made them widely applicable in biomedical applications, with minimal adversity. This review highlights the importance of using natural biopolymer-based intravitreal hydrogel drug delivery systems for glaucoma treatment over conventional methods.

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Patient-Derived Organoids: A Game-Changer in Personalized Cancer Medicine

Abbasian,

Sobhani,

Sisakht

et al. 2024

Stem Cell Rev and Rep

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Methods for Engineering of Multicellular Spheroids to Reconstitute the Liver Tissue

Cited by 5 publications

References 14 publications

Shear rheology of methyl cellulose based solutions for cell mechanical measurements at high shear rates

Shear rheology of methyl cellulose based solutions for cell mechanical measurements at high shear rates

Intravitreal Injectable Hydrogels for Sustained Drug Delivery in Glaucoma Treatment and Therapy

Patient-Derived Organoids: A Game-Changer in Personalized Cancer Medicine

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