2023
DOI: 10.1002/btpr.3345
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Methods for identifying precipitates and improving stability of chemically defined highly concentrated cell culture media

Abstract: Currently, within the biopharmaceutical industry, media development is a key area of development as the ratios and concentrations of media components such as amino acids, metals, vitamins, sugars, salts, and buffering agents play arguably the largest role in cellular productivity and product quality. However, optimizing media for these targets often conflicts with solubility limitations and slow‐rate chemical reactions that result in precipitation formation. Here we present methods such as inductively coupled … Show more

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