Relevance. Road traffic accidents are a source of significant medical, demographic, social and economic losses. To reduce the volume of medical and sanitary consequences of road accidents, to achieve the targets of the national project “Safe and High-Quality Roads”, it is necessary to further improve the technologies for providing medical care to victims of road accidents at all stages, including their adaptation to the regional characteristics of road traffic traumatism, and the mechanism of interaction between medical organizations performing the functions of trauma centers. This task can be solved provided that a system of information exchange between trauma centers is created, as well as the organization of monitoring of health consequences in road accidents on its basis. To accumulate and analyze information, a polynosological register, a type of distributed database, is to be used.Intention – to substantiate the expediency to organize monitoring of the health consequences of road traffic accidents.Methodology. Regulatory documents were reviewed as well as results of Russian and foreign scientific research of organizational approaches to the provision of specialized medical care to victims of road accidents at the hospital stage, and also algorithms of introducing information technologies into the activities of medical organizations. The search for sources was performed in specialized scientific search systems (eLibrary, National Library of Medicine – PubMed, Scopus etc.).Results and Discussion. The organization of monitoring of the medical and social consequences of road traffic accidents at the level of the territories of the Russian Federation has been substantiated (including its purpose, tasks, coordinators and implementers). The directions of using the monitoring results were determined.Conclusion. Monitoring of medical and social consequences of road traffic accidents will provide a reliable assessment of their scope in the regions of the country. Besides, health authorities will get reliable information to develop effective measures for reducing medical, demographic, social and economic losses associated with road traffic accidents.