Methods for quantitative susceptibility and R2* mapping in whole post-mortem brains at 7T

Wang, Chaoyue; Foxley, Sean; Ansorge, Olaf; Bangerter-Christensen, Sarah; Chiew, Mark; Leonte, Anna; Ral., Menke; Mollink, Jeroen; Pallebage-Gamarallage, Menuka; Turner, Martin R; Miller, Karla L.; Tendler, Benjamin C.

doi:10.1101/2020.05.07.082479

Cited by 3 publications

(1 citation statement)

References 57 publications

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“…In contrast to the imaging of tissue-blocks or slices [10][11][12] -which is usually performed in smallbore scanners and/or using specialized receiver-coils -ex vivo whole-brain MR imaging has been frequently performed at 7T main field strength 4,13 , since it generally provides a higher signal-to-noise-ratio (SNR) per unit time. SNR is usually the most limiting factor in terms of achievable resolution; and increasing SNR solely by signal averaging leads to an unfavorable quadratic increase of acquisition time.…”

Section: Introductionmentioning

confidence: 99%

Imaging Multiple Sclerosis Pathology at 160μm Isotropic Resolution by Human Whole-BrainEx VivoMagnetic Resonance Imaging at 3T

Weigel

Dechent

Galbusera

et al. 2021

Preprint

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Postmortem magnetic resonance imaging (MRI) of the fixed healthy and diseased human brain facilitates spatial resolutions and image quality that is not achievable with in vivo MRI scans. Though challenging - and almost exclusively performed at 7T field strength - depicting the tissue architecture of the entire brain in fine detail is invaluable since it enables the study of neuroanatomy and uncovers important pathological features in neurological disorders. The objectives of the present work were (i) to develop a 3D isotropic ultra-high-resolution imaging approach for human whole-brain ex vivo acquisitions working on a standard clinical 3T MRI system, and (ii) to explore the sensitivity and specificity of this concept for specific pathoanatomical features of multiple sclerosis. The reconstructed images demonstrate unprecedented resolution and soft tissue contrast of the diseased human brain at 3T, thus allowing visualization of sub-millimetric lesions in the different cortical layers and in the cerebellar cortex, as well as unique cortical lesion characteristics such as the presence of incomplete / complete iron rims, and patterns of iron accumulation. Further details such as the subpial molecular layer, the line of Gennari, and some intrathalamic nuclei are also well distinguishable.

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Section: Introductionmentioning

confidence: 99%

Imaging Multiple Sclerosis Pathology at 160μm Isotropic Resolution by Human Whole-BrainEx VivoMagnetic Resonance Imaging at 3T

Weigel

Dechent

Galbusera

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

Imaging multiple sclerosis pathology at 160 μm isotropic resolution by human whole-brain ex vivo magnetic resonance imaging at 3 T

Weigel

Dechent

Galbusera

et al. 2021

Sci Rep

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Postmortem magnetic resonance imaging (MRI) of the fixed healthy and diseased human brain facilitates spatial resolutions and image quality that is not achievable with in vivo MRI scans. Though challenging—and almost exclusively performed at 7 T field strength—depicting the tissue architecture of the entire brain in fine detail is invaluable since it enables the study of neuroanatomy and uncovers important pathological features in neurological disorders. The objectives of the present work were (1) to develop a 3D isotropic ultra-high-resolution imaging approach for human whole-brain ex vivo acquisitions working on a standard clinical 3 T MRI system; and (2) to explore the sensitivity and specificity of this concept for specific pathoanatomical features of multiple sclerosis. The reconstructed images demonstrate unprecedented resolution and soft tissue contrast of the diseased human brain at 3 T, thus allowing visualization of sub-millimetric lesions in the different cortical layers and in the cerebellar cortex, as well as unique cortical lesion characteristics such as the presence of incomplete/complete iron rims, and patterns of iron accumulation. Further details such as the subpial molecular layer, the line of Gennari, and some intrathalamic nuclei are also well distinguishable.

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The Digital Brain Bank, an open access platform for post-mortem datasets

Tendler

Hanayik

Ansorge

et al. 2021

Preprint

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Post-mortem MRI provides the opportunity to acquire high-resolution datasets to investigate neuroanatomy, and validate the origins of image contrast through microscopy comparisons. We introduce the Digital Brain Bank (open.win.ox.ac.uk/DigitalBrainBank), an interactive data discovery and release platform providing open access to curated, multimodal post-mortem neuroimaging datasets. Datasets span three themes - Digital Neuroanatomist: data for neuroanatomical investigations; Digital Brain Zoo: data for comparative neuroanatomy; Digital Pathologist: data for neuropathology investigations. The first Digital Brain Bank release includes fourteen distinctive whole-brain diffusion MRI datasets for structural connectivity investigations, alongside microscopy and complementary MRI modalities. This includes one of the highest-resolution whole-brain human diffusion MRI datasets ever acquired, whole-brain diffusion MRI in seven non-human primate species, and one of the largest post-mortem whole-brain cohort imaging studies in neurodegeneration. Taken together, the Digital Brain Bank provides a cross-scale, cross-species investigation framework facilitating the incorporation of post-mortem data into neuroimaging studies.

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Methods for quantitative susceptibility and R2* mapping in whole post-mortem brains at 7T

Cited by 3 publications

References 57 publications

Imaging Multiple Sclerosis Pathology at 160μm Isotropic Resolution by Human Whole-BrainEx VivoMagnetic Resonance Imaging at 3T

Imaging Multiple Sclerosis Pathology at 160μm Isotropic Resolution by Human Whole-BrainEx VivoMagnetic Resonance Imaging at 3T

Imaging multiple sclerosis pathology at 160 μm isotropic resolution by human whole-brain ex vivo magnetic resonance imaging at 3 T

The Digital Brain Bank, an open access platform for post-mortem datasets

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