BackgroundThis study aims to explore the ideal breast size by assessing the relationship between mastectomy to free flap weight ratio and complications as well as patient‐reported outcomes in autologous breast reconstruction (ABR).MethodA retrospective review of patients undergoing bilateral immediate ABR with mastectomy and flap weights available was completed. Patients were divided into three groups based on the ratio of mastectomy to flap weights. The patients were grouped as “maintained” if the flap weight was within 10% of the mastectomy weight. Patients with a weight difference greater than 10% were used to declare “downsized” or “upsized.” Outcomes included complications and four domains of the BREAST‐Q at 1‐year postoperatively.ResultsThree hundred and fifty‐nine patients were included in the analysis, of which 112 were downsized, 91 maintained, and 156 upsized, respectively. Presence of complications did not significantly differ among the groups. At 1‐year postoperatively, Sexual Well‐being significantly differed (p = 0.033). Between preoperative and 1 year, patients who upsized experienced an improvement in Satisfaction with Breasts by 16 points (p < 0.001), while patients who downsized experienced a decline in Physical Well‐being of the Chest by 7 points (p = 0.016). Multivariable linear regression model showed that Sexual Well‐being was 13 points lower in the downsized cohort than in the maintained cohort (β = −13, 95% confidence interval: −21 to −5.4; p = 0.001).ConclusionAlthough complication rates do not significantly differ between the three cohorts, patients who downsize may have lower Sexual Well‐being postoperatively. Surgeons should consider our preliminary findings to counsel patients preoperatively about the predicted breast size and the impact of downsizing on sexual health.