Methods of synthesis, properties and biomedical applications of polyhydroxyalkanoates: a review

Grigore, Mădălina Elena; Grigorescu, Ramona Marina; Iancu, Lorena; Ion, Rodica‐Mariana; Zaharia, Cătălin; Andrei, Elena Ramona

doi:10.1080/09205063.2019.1605866

Cited by 120 publications

(77 citation statements)

References 104 publications

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“…The high crystallinity of P(3HB-co-3HV) is due to the isodimorphism behavior of this copolymer, whereby the transformation of crystallization from the P(3HB) lattice to the P(3HV) lattice occurs at around 37-40 mol% 3HV (Kunioka et al, 1989;Liu et al, 2014;Wang et al, 2016). At this fraction of 3HV, both the 3HB and 3HV monomers, which are similar in size, can co-crystallize into the same lattice (Doi, 1990;Grigore et al, 2019). This phenomenon only takes place in copolymers of P(3HB-co-3HV).…”

Section: P(3hb-co-3hv)mentioning

confidence: 99%

“…The characteristics of P(4HB) homopolymer is very similar to ultra-high-molecular-weight polyethylene. When the 4HB fraction was increased from 64 to 100 mol%, it could be considered as a strong elastic polymer with the ability to extend with force and then return to its original position since the tensile strength ranged from 17 to 104 MPa, unlike P(3HB): up to 2.5 times the strength of P(3HB) (Saito et al, 1996;Bhubalan et al, 2010;Grigore et al, 2019).…”

Section: P(3hb-co-3hv)mentioning

confidence: 99%

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Can Polyhydroxyalkanoates Be Produced Efficiently From Waste Plant and Animal Oils?

Surendran

Lakshmanan

Chee

et al. 2020

Front. Bioeng. Biotechnol.

120

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Polyhydroxyalkanoates (PHAs) are a potential replacement for some petrochemical-based plastics. PHAs are polyesters synthesized and stored by various bacteria and archaea in their cytoplasm as water-insoluble inclusions. PHAs are usually produced when the microbes are cultured with nutrient-limiting concentrations of nitrogen, phosphorus, sulfur, or oxygen and excess carbon sources. Such fermentation conditions have been optimized by industry to reduce the cost of PHAs produced commercially. Industrially, these biodegradable polyesters are derived from microbial fermentation processes utilizing various carbon sources. One of the major constraints in scaling-up PHA production is the cost of the carbon source metabolized by the microorganisms. Hence, cheap and renewable carbon substrates are currently being investigated around the globe. Plant and animal oils have been demonstrated to be excellent carbon sources for high yield production of PHAs. Waste streams from oil mills or the used oils, which are even cheaper, are also used. This approach not only reduces the production cost for PHAs, but also makes a significant contribution toward the reduction of environmental pollution caused by the used oil. Advancements in the genetic and metabolic engineering of bacterial strains have enabled a more efficient utilization of various carbon sources, in achieving high PHA yields with specified monomer compositions. This review discusses recent developments in the biosynthesis and classification of various forms of PHAs produced using crude and waste oils from the oil palm and fish industries. The biodegradability of the PHAs produced from these oils will also be discussed.

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Section: P(3hb-co-3hv)mentioning

confidence: 99%

Section: P(3hb-co-3hv)mentioning

confidence: 99%

Can Polyhydroxyalkanoates Be Produced Efficiently From Waste Plant and Animal Oils?

Surendran

Lakshmanan

Chee

et al. 2020

Front. Bioeng. Biotechnol.

120

View full text Add to dashboard Cite

show abstract

“…Polyhydroxyalkanoates (PHAs) are polyesters of 3-, 4-, 5-and 6-hydroxyalkanoic acid which are synthesized using microbial biotechnology approaches involving bacterial fermentation. Some bacteria store PHAs as an intracellular storage compounds for energy and carbon, normally under conditions of nutrient limitation (e.g., nitrogen, sulphur, oxygen, magnesium or phosphorus), with the excess of carbon (e.g., carbohydrates, lipids, fatty acids) [10][11][12][13]. The number of carbon atoms in a monomer unit is crucial to the properties of PHAs.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Influence of 45S5 and Cu-Containing 45S5 Bioactive Glass (BG) on the Biological Properties of Novel Polyhydroxyalkanoate (PHA)/BG Composites

et al. 2020

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Polyhydroxyalkanoates (PHAs), due to their biodegradable and biocompatible nature and their ability to be formed in complex structures, are excellent candidates for fabricating scaffolds used in tissue engineering. By introducing inorganic compounds, such as bioactive glasses (BGs), the bioactive properties of PHAs can be further improved. In addition to their outstanding bioactivity, BGs can be additionally doped with biological ions, which in turn extend the functionality of the BG-PHA composite. Here, different PHAs were combined with 45S5 BG, which was additionally doped with copper in order to introduce antibacterial and angiogenic properties. The resulting composite was used to produce scaffolds by the salt leaching technique. By performing indirect cell biology tests using stromal cells, a dose-depending effect of the dissolution products released from the BG-PHA scaffolds could be found. In low concentrations, no toxic effect was found. Moreover, in higher concentrations, a minor reduction of cell viability combined with a major increase in VEGF release was measured. This result indicates that the fabricated composite scaffolds are suitable candidates for applications in soft and hard tissue engineering. However, more in-depth studies are necessary to fully understand the release kinetics and the resulting long-term effects of the BG-PHA composites.

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“…An example was a mixture of P(3HHx-co-3HO) with tamulosin, which was characterized by better penetration of the active substance into the skin, compared to a mixture of the drug with a short-chain, highly crystalline P(3HB) (Wang et al, 2003b ). For further details, the reader is encouraged to see the following reviews: Chen et al ( 2017 ); Lizarraga et al ( 2018 ); Elmowafy et al ( 2019 ), and Grigore et al ( 2019 ).…”

Section: Trends Unveiledmentioning

confidence: 99%

What Has Been Trending in the Research of Polyhydroxyalkanoates? A Systematic Review

Guzik

Witko

Steinbüchel

et al. 2020

Front. Bioeng. Biotechnol.

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Over the past decades, enormous progress has been achieved with regard to research on environmentally friendly polymers. One of the most prominent families of such biopolymers are bacterially synthesized polyhydroxyalkanoates (PHAs) that have been known since the 1920s. However, only as recent as the 1990s have extensive studies sprung out exponentially in this matter. Since then, different areas of exploration of these intriguing materials have been uncovered. However, no systematic review of undertaken efforts has been conducted so far. Therefore, we have performed an unbiased search of up-to-date literature to reveal trending topics in the research of PHAs over the past three decades by data mining of 2,227 publications. This allowed us to identify eight past and current trends in this area. Our study provides a comprehensive review of these trends and speculates where PHA research is heading.

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Methods of synthesis, properties and biomedical applications of polyhydroxyalkanoates: a review

Cited by 120 publications

References 104 publications

Can Polyhydroxyalkanoates Be Produced Efficiently From Waste Plant and Animal Oils?

Can Polyhydroxyalkanoates Be Produced Efficiently From Waste Plant and Animal Oils?

Comparison of the Influence of 45S5 and Cu-Containing 45S5 Bioactive Glass (BG) on the Biological Properties of Novel Polyhydroxyalkanoate (PHA)/BG Composites

What Has Been Trending in the Research of Polyhydroxyalkanoates? A Systematic Review

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