Methods to prepare dopamine/polydopamine modified alginate hydrogels and their special improved properties for drug delivery

Gao, Bo; Chen, Liheng; Zhao, Yilun; Yan, Xin; Wang, Xiaoying; Zhou, Changren; Shi, Yunfeng; Wang, Xue

doi:10.1016/j.eurpolymj.2018.11.025

Cited by 46 publications

(24 citation statements)

References 30 publications

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“…The oxidation of Alg to Alg OX was confirmed by the signal at 5.4 ppm (Figure 7a), which corresponded to a hemiacetalic proton formed from aldehyde and the neighboring hydroxyl group, and by the absence of a signal at 9.5-10 ppm of a free aldehyde group, in agreement with Gomez [26]. The soluble macromolecules of AlgOX-DA were characterized in D2O solutions using 1 H-NMR (see Gao [38]) in order to increase the solubility of AlgOX-DA in D2O, the NMR tube was preheated at 40 °C.…”

Section: Nmr Spectroscopysupporting

confidence: 66%

“…Of note, the DS of AlgOX-DA determined after chemical hydrolysis allowed quantitative evaluations and, therefore, DS was employed for in vitro release studies and AlgOX-DA exposure to the cell line. For instance, for AlgOX-DA, the DS for DA we found was almost double that previously studied for a Alg hydrogel containing DA, namely 15.86 ± 2.04 µg DA/mg DA-hydrogel already studied for drug delivery applications [38].…”

Section: Discussionmentioning

confidence: 45%

“…The soluble macromolecules of AlgOX-DA were characterized in D 2 O solutions using 1 H-NMR (see Gao [38]) in order to increase the solubility of AlgOX-DA in D 2 O, the NMR tube was preheated at 40 • C.…”

Section: Nmr Spectroscopymentioning

confidence: 99%

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Oxidized Alginate Dopamine Conjugate: In Vitro Characterization for Nose-to-Brain Delivery Application

et al. 2021

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Background: The blood–brain barrier (BBB) bypass of dopamine (DA) is still a challenge for supplying it to the neurons of Substantia Nigra mainly affected by Parkinson disease. DA prodrugs have been studied to cross the BBB, overcoming the limitations of DA hydrophilicity. Therefore, the aim of this work is the synthesis and preliminary characterization of an oxidized alginate-dopamine (AlgOX-DA) conjugate conceived for DA nose-to-brain delivery. Methods: A Schiff base was designed to connect oxidized polymeric backbone to DA and both AlgOX and AlgOX-DA were characterized in terms of Raman, XPS, FT-IR, and 1H- NMR spectroscopies, as well as in vitro mucoadhesive and release tests. Results: Data demonstrated that AlgOX-DA was the most mucoadhesive material among the tested ones and it released the neurotransmitter in simulated nasal fluid and in low amounts in phosphate buffer saline. Results also demonstrated the capability of scanning near-field optical microscopy to study the structural and fluorescence properties of AlgOX, fluorescently labeled with fluorescein isothiocyanate microstructures. Interestingly, in SH-SY5Y neuroblastoma cell line up to 100 μg/mL, no toxic effect was derived from AlgOX and AlgOX-DA in 24 h. Conclusions: Overall, the in vitro performances of AlgOX and AlgOX-DA conjugates seem to encourage further ex vivo and in vivo studies in view of nose-to-brain administration.

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Section: Nmr Spectroscopysupporting

confidence: 66%

Section: Discussionmentioning

confidence: 45%

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Oxidized Alginate Dopamine Conjugate: In Vitro Characterization for Nose-to-Brain Delivery Application

et al. 2021

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“…Hadijev et al [ 180 ] studied hydrogels which mostly applied drug diffusion as a release mechanism; however, this can be changed with the properties to broadly change the solute diffusion coefficient as the gel system swells. According to Gao et al [ 183 ], mechanism of release of hydrogels can be modified to have more steady release behavior by adding some copolymer which is able to interact and may change the chemical structure, morphology, and rheology characteristics, thus affecting release behavior and mechanism.…”

Section: Mechanism Of Drug Release From Alginate Nano/microparticlmentioning

confidence: 99%

Current Status of Alginate in Drug Delivery

Hariyadi

Islam

2020

Advances in Pharmacological and Pharmaceutical Sciences

143

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Alginate is one of the natural polymers that are often used in drug- and protein-delivery systems. The use of alginate can provide several advantages including ease of preparation, biocompatibility, biodegradability, and nontoxicity. It can be applied to various routes of drug administration including targeted or localized drug-delivery systems. The development of alginates as a selected polymer in various delivery systems can be adjusted depending on the challenges that must be overcome by drug or proteins or the system itself. The increased effectiveness and safety of sodium alginate in the drug- or protein-delivery system are evidenced by changing the physicochemical characteristics of the drug or proteins. In this review, various routes of alginate-based drug or protein delivery, the effectivity of alginate in the stem cells, and cell encapsulation have been discussed. The recent advances in the in vivo alginate-based drug-delivery systems as well as their toxicities have also been reviewed.

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“…Hydrogels are an emerging material that has attracted significant fundamental and applied interest for wastewater treatment 411 , tissue engineering 325,412 , drug delivery 413,414 , wearable electronics 415 , and energystorage materials 314 . Apart from the aforementioned synthetic processes, the following recent works of functional hydrogel have been added new horizons in numerous fields of application.…”

Section: Other Applicationsmentioning

confidence: 99%