Methods to Study Mucoadhesive Dosage Forms

Maleimide-functionalized carboxymethyl cellulose: A novel mucoadhesive polymer for transmucosal drug delivery

“…The mucoadhesive capability of the mucoadhesive CMC-MAL tablets was evaluated on porcine buccal tissue using a texture analyzer to determine the MDF -the highest force required to detach the polymer sample from the mucosa and total work of adhesion which is the area under the force-time curve (Davidovich-Pinhas & Bianco-Peled, 2014). The findings revealed that CMC-MAL tablets had a significantly higher strength considering both MDF and total work of adhesion compared to the tablets prepared from unmodified CMC or chitosan, which represent the first-generation mucoadhesive polymers (Figure 7).…”

Investigations to Evaluate Gastric Mucoadhesion of an Organic Product to Ameliorate Gastritis

“…Mucoadhesion of Caricol ® -Gastro was investigated using gastric porcine excised mucosa on a modified falling liquid film technique as previously described by Gradauer et al [39]. For this, porcine stomach was obtained from freshly sacrificed pigs (age < 6 months; Marcher Fleischwerke, Graz, Austria) and transported in 4 • C Krebs buffer (Sigma-Aldrich ® , Munich, Germany) to the laboratory.…”

“…As an alternative, in vitro examinations can be carried out to predict the behavior of a formulation under physiological conditions and to improve the understanding of underlying mechanisms of action. This would reduce costs incurred by clinical studies, enable a faster screening of dosage forms, and facilitate rational formulation design or-if necessary-formulation improvement [39,40]. However, for the characterization of mucoadhesive effects, there is no universally valid in vitro model available Therefore, it is hypothesized that a combination of coordinated methods has to be applied.…”

“…The most frequently used in vitro methods include rheological techniques, surface plasmon resonance, isothermal titration calorimetry, tensile strength test, shear strength test, peel strength test, and contact angle measurements performed on specific surfaces [28,34,41]. In addition, mucoadhesion can be tested ex vivo using excised tissues [38,39,41,42]. Thereby, the everted gut sac technique, atomic force microscopy and the falling liquid film method are the most frequently used techniques to study mucoadhesion along the oro-gastrointestinal tract [43][44][45].…”

Chitosan/β-glycerophosphate in situ gelling mucoadhesive systems for intravesical delivery of mitomycin-C

“…Polymers exhibiting the ability to adhere to mucosal tissues in the bladder are typically referred as mucoadhesive. The mucoadhesive dosage forms are commonly prepared using polymers that interact with glycoprotein components of mucin through non-covalent bonding like hydrogen bonds, chain entanglements and electrostatic interactions (Khutoryanskiy, 2011, Davidovich-Pinhas and Bianco-Peled, 2014, Khutoryanskiy, 2014). They are particularly desirable for drug delivery to the bladder because they may be able to overcome some inherent limitations of intravesical administration such as substantial drug dilution and wash-out during urine formation and elimination.…”