Methohexital and cocaine self-administration under fixed-ratio and second-order schedules

Spear, Debra J.; Muntaner, Carles; Goldberg, Steven R.; Katz, Jonathan L.

doi:10.1016/0091-3057(91)90300-q

Cited by 24 publications

(15 citation statements)

References 9 publications

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“…The peak rates of responding maintained by 4 μg/kg i.v. dose of THC in this study were similar to or greater than the peak rates of responding maintained by intravenous injections of cocaine, d-amphetamine, nicotine, methohexital or midazolam in previous studies using the same primate species and the same schedule of intravenous drug injection (Goldberg, 1973;Spear et al, 1991;Sannerud et al, 1994;Munzar et al, 2001). Interestingly, overall response rates, injections per session and total THC intake per session in this study with drug-naïve monkeys (Justinova et al, 2003) were greater than in our previous study (Tanda et al, 2000) in which monkeys had a previous history of cocaine self-administration.…”

Section: Self-administration Of Cannabinoids By Laboratory Animalssupporting

confidence: 79%

Self-administration of cannabinoids by experimental animals and human marijuana smokers

Justinová

Goldberg

Heishman

2005

Pharmacology Biochemistry and Behavior

115

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Drug self-administration behavior has been one of the most direct and productive approaches for studying the reinforcing effects of psychoactive drugs, which are critical in determining their abuse potential. Cannabinoids, which are usually abused by humans in the form of marijuana, have become the most frequently abused illicit class of drugs in the United States. The early elucidation of the structure and stereochemistry of delta-9-tetrahydrocannabinol (THC) in 1964, which is now recognized as the principal psychoactive ingredient in marijuana, activated cannabinoid research worldwide. This review examines advances in research on cannabinoid self-administration behavior by humans and laboratory animals. There have been numerous laboratory demonstrations of the reinforcing effects of cannabinoids in human subjects, but reliable self-administration of cannabinoids by laboratory animals has only recently been demonstrated. It has now been shown that strong and persistent self-administration behavior can be maintained in experimentally and drugnaïve squirrel monkeys by doses of THC comparable to those in marijuana smoke inhaled by humans. Furthermore, reinforcing effects of some synthetic CB 1 cannabinoid agonists have been recently reported using intravenous and intracerebroventricular self-administration procedures in rats and mice. These findings support previous conclusions that THC has a pronounced abuse liability comparable to other drugs of abuse under certain experimental conditions. Self-administration of THC by squirrel monkeys provides the most reliable animal model for human marijuana abuse available to date. This animal model now makes it possible to study the relative abuse liability of other natural and synthetic cannabinoids and to preclinically assess new therapeutic strategies for the treatment or prevention of marijuana abuse in humans.

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Section: Self-administration Of Cannabinoids By Laboratory Animalssupporting

confidence: 79%

Self-administration of cannabinoids by experimental animals and human marijuana smokers

Justinová

Goldberg

Heishman

2005

Pharmacology Biochemistry and Behavior

115

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“…Under the present fixed-ratio schedule of intravenous drug self-administration, the optimum rates of responding maintained by THC were similar to or greater than the optimum rates of responding maintained by intravenous injections of cocaine, damphetamine, nicotine, methohexital or midazolam in previous studies using the same primate species and the same schedule of intravenous drug injection (Goldberg 1973;Spear et al 1991;Sannerud et al 1994;Munzar et al 2001). Vehicle substitution for THC immediately Fig.…”

Section: Discussionmentioning

confidence: 52%

Self-administration of ?9-tetrahydrocannabinol (THC) by drug naive squirrel monkeys

et al. 2003

Self Cite

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“…A paradigm that provides an operational measure of incentive-motivation for drug administration is intravenous self-administration of drugs under a second-order schedule of reinforcement Everitt and Robbins 2000). This paradigm has been used extensively to study drug-seeking behavior in humans (Mello and Mendelson 1985;Henningfield et al 1987;Lamb et al 1991), non-human primates (Goldberg 1973;Katz 1979;Johanson 1982;Spear et al 1991;Spealman et al 1991;Negus et al 1995) and rats (Whitelaw et al 1996;Arroyo et al 1998;Markou et al 1999). In the second-order schedule paradigm, drugseeking behavior is assessed by the rates of responding during the first drug-free interval of the self-administration session.…”

Section: Introductionmentioning

confidence: 98%

Cocaine-seeking behavior after extended cocaine-free periods in rats: role of conditioned stimuli

Semenova

Markou

2002

Psychopharmacology

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The results indicated that non-contingent CS presentation had no effect after 23 h of no access to cocaine, increased drug-seeking behavior on day 7 of the cocaine-free period independent of binge exposure, and a strong tendency to increase drug-seeking behavior only in binge-exposed rats, on day 30 of the cocaine-free period, illustrating the interactive effects of conditioned stimuli with the extended cocaine-free period.

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Methohexital and cocaine self-administration under fixed-ratio and second-order schedules

Cited by 24 publications

References 9 publications

Self-administration of cannabinoids by experimental animals and human marijuana smokers

Self-administration of cannabinoids by experimental animals and human marijuana smokers

Self-administration of ?9-tetrahydrocannabinol (THC) by drug naive squirrel monkeys

Cocaine-seeking behavior after extended cocaine-free periods in rats: role of conditioned stimuli

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