Methotrexate-loaded metal-organic frameworks on the basis of γ-cyclodextrin: Design, characterization, in vitro and in vivo investigation

Kritskiy, Iliya; Volkova, Тatyana V.; Sapozhnikova, T. A.; Mazur, Anton S.; Tolstoy, Peter M.; Терехова, И. В.

doi:10.1016/j.msec.2020.110774

Cited by 33 publications

(17 citation statements)

References 51 publications

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“…More importantly, co-crystallization does not alter the physicochemical properties of the drug, which can be advantageously exploited to improve the loading efficiency and enhance the drugs solubility. As an example, poorly soluble drugs, such as IBU 184 , lansoprazole 67 , leflunomide 93 and methotrexate (MTX) 185 were successfully embedded in γ -CD-MOFs using the co-crystallization method and the drug loading was equal to or higher than that by an impregnation method.…”

Section: Drug Loading and Characterizationsmentioning

confidence: 99%

“…Currently, improving the pharmacokinetic profile of MOFs carriers is a primary drug delivery strategy to optimize drug targeting toward diseased tissues or cells. A great number of studies 20 , 185 focused on the capability to improve drug bioavailability and biodistribution. The absorption, distribution, metabolism and excretion (ADME) processes differ in MOFs and then have consequences on the pharmacokinetic proﬁle of the loaded drugs 57 , 251 , 252 , 253 .…”

Section: Biopharmaceutics Of Mofs and Mofs-based Ddssmentioning

confidence: 99%

“…Kritskiy et al. 185 reported enhanced bioavailability of MTX loaded in γ -CD-MOF with increased dissolution of MTX and the decreased drug permeability through the lipophilic membrane. At the same time, the γ -CD-MOF was suitable for long-term administration due to its elimination with a longer time ( T 1/2 = 4.5 h) than that of MTX ( T 1/2= 1.5 h).…”

Section: Biopharmaceutics Of Mofs and Mofs-based Ddssmentioning

confidence: 99%

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Metal-organic frameworks for advanced drug delivery

et al. 2021

Acta Pharmaceutica Sinica B

295

116

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Metal-organic frameworks (MOFs), comprised of organic ligands and metal ions/metal clusters via coordinative bonds are highly porous, crystalline materials. Their tunable porosity, chemical composition, size and shape, and easy surface functionalization make this large family more and more popular for drug delivery. There is a growing interest over the last decades in the design of engineered MOFs with controlled sizes for a variety of biomedical applications. This article presents an overall review and perspectives of MOFs-based drug delivery systems (DDSs), starting with the MOFs classification adapted for DDSs based on the types of constituting metals and ligands. Then, the synthesis and characterization of MOFs for DDSs are developed, followed by the drug loading strategies, applications, biopharmaceutics and quality control. Importantly, a variety of representative applications of MOFs are detailed from a point of view of applications in pharmaceutics, diseases therapy and advanced DDSs. In particular, the biopharmaceutics and quality control of MOFs-based DDSs are summarized with critical issues to be addressed. Finally, challenges in MOFs development for DDSs are discussed, such as biostability, biosafety, biopharmaceutics and nomenclature.

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Section: Drug Loading and Characterizationsmentioning

confidence: 99%

Section: Biopharmaceutics Of Mofs and Mofs-based Ddssmentioning

confidence: 99%

Section: Biopharmaceutics Of Mofs and Mofs-based Ddssmentioning

confidence: 99%

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Metal-organic frameworks for advanced drug delivery

et al. 2021

Acta Pharmaceutica Sinica B

295

116

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“…Thermal gravimetric analysis (TGA) was performed on a NETZSCH STA 449 F5/F3 Jupiter instrument (Netzsch, Germany). The surface area of the samples was determined by N 2 adsorption/desorption at liquid nitrogen temperatures on an ASAP 2460 analyzer (Thermo Fisher Scientific Surfer, ASAP 2460, USA) [ 36 , 40 ].…”

Section: Methodsmentioning

confidence: 99%

Microvesicle-camouflaged biomimetic nanoparticles encapsulating a metal-organic framework for targeted rheumatoid arthritis therapy

et al. 2022

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Background Methotrexate (MTX) has been highlighted for Rheumatoid arthritis (RA) treatment, however, MTX does not accumulate well at inflamed sites, and long-term administration in high doses leads to severe side effects. In this study, a novel anti-RA nanoparticle complex was designed and constructed, which could improve the targeted accumulation in inflamed joints and reduce side effects. Results Here, we prepared a pH-sensitive biomimetic drug delivery system based on macrophage-derived microvesicle (MV)-coated zeolitic imidazolate framework-8 nanoparticles that encapsulated the drug methotrexate (hereafter MV/MTX@ZIF-8). The MV/MTX@ZIF-8 nanoparticles were further modified with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate (polyethylene glycol)-2000] (hereafter FPD/MV/MTX@ZIF-8) to exploit the high affinity of folate receptor β for folic acid on the surface of activated macrophages in RA. MTX@ZIF-8 nanoparticles showed high DLE (~ 70%) and EE (~ 82%). In vitro study showed that effective drug release in an acidic environment could be achieved. Further, we confirmed the activated macrophage could uptake much more FPD/MV/MTX@ZIF-8 than inactivated cells. In vivo biodistribution experiment displayed FPD/MV/MTX@ZIF-8 nanoparticles showed the longest circulation time and best joint targeting. Furthermore, pharmacodynamic experiments confirmed that FPD/MV/MTX@ZIF-8 showed sufficient therapeutic efficacy and safety to explore clinical applications. Conclusions This study provides a novel approach for the development of biocompatible drug-encapsulating nanomaterials based on MV-coated metal-organic frameworks for effective RA treatment. Graphical Abstract

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Section: Synthesis and Characterization Of Mtx@zif-8mentioning

confidence: 99%

Microvesicle-camouflaged biomimetic nanoparticles encapsulating a metal-organic framework for targeted rheumatoid arthritis therapy

Wang

Jia

Zheng

et al. 2022

Preprint

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Background: Methotrexate (MTX) has been highlighted for Rheumatoid arthritis (RA) treatment, however, MTX does not accumulate well at inflamed sites, and long-term administration in high doses leads to severe side effects. In this study, a novel anti-RA nanoparticle complex was designed and constructed, which could improve the targeted accumulation in inflamed joints and reduce side effects.Results: Here, we prepared a pH-sensitive biomimetic drug delivery system based on macrophage-derived microvesicle (MV)-coated zeolitic imidazolate framework-8 nanoparticles that encapsulated the drug methotrexate (hereafter MV/MTX@ZIF-8). The MV/MTX@ZIF-8 nanoparticles were further modified with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate (polyethylene glycol)-2000] (hereafter FPD/MV/MTX@ZIF-8) to exploit the high affinity of folate receptor β for folic acid on the surface of activated macrophages in RA. MTX@ZIF-8 nanoparticles showed high DLE (~70%) and EE (~82%). In vitro study showed that effective drug release in an acidic environment could be achieved. Further, we confirmed the activated macrophage could uptake much more FPD/MV/MTX@ZIF-8 than inactivated cells. In vivo biodistribution experiment displayed FPD/MV/MTX@ZIF-8 nanoparticles showed the longest circulation time and best joint targeting. Furthermore, pharmacodynamic experiments confirmed that FPD/MV/MTX@ZIF-8 showed sufficient therapeutic efficacy and safety to explore clinical applications.Conclusion: This study provides a novel approach for the development of biocompatible drug-encapsulating nanomaterials based on MV-coated metal-organic frameworks for effective RA treatment.

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Methotrexate-loaded metal-organic frameworks on the basis of γ-cyclodextrin: Design, characterization, in vitro and in vivo investigation

Cited by 33 publications

References 51 publications

Metal-organic frameworks for advanced drug delivery

Metal-organic frameworks for advanced drug delivery

Microvesicle-camouflaged biomimetic nanoparticles encapsulating a metal-organic framework for targeted rheumatoid arthritis therapy

Microvesicle-camouflaged biomimetic nanoparticles encapsulating a metal-organic framework for targeted rheumatoid arthritis therapy

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