Methylation detection of circulating tumor cell miR-486-5p/miR-34c-5p in the progression of colorectal cancer

Li, Guolei; Hu, Xuhua; Wang, Guiying; Chen, Geng

doi:10.1007/s12094-022-02973-x

Cited by 2 publications

(1 citation statement)

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“…MiR-34 inhibits the proliferation of in situ and tumor-derived cells ( Li et al, 2021b ), and all three isoforms ( miR-34a/b/c ) have been shown to inhibit adenoma formation ( Jiang & Hermeking, 2017 ). MiR-34a also affects the development of the epithelial-mesenchymal transition (EMT) inhibitory effect ( Li et al, 2021b , 2023 ). Furthermore, regulation and activation of miR-34 by the P53 pathway has been confirmed ( Iftekhar et al, 2021 ).…”

Section: Role and Mechanism Of Pks+ E Coli In The ...mentioning

confidence: 99%

Three specific gut bacteria in the occurrence and development of colorectal cancer: a concerted effort

Gong

Adomako-Bonsu

Wang

et al. 2023

PeerJ

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Colorectal cancer (CRC), which develops from the gradual evolution of tubular adenomas and serrated polyps in the colon and rectum, has a poor prognosis and a high mortality rate. In addition to genetics, lifestyle, and chronic diseases, intestinal integrity and microbiota (which facilitate digestion, metabolism, and immune regulation) could promote CRC development. For example, enterotoxigenic Bacteroides fragilis, genotoxic Escherichia coli (pks+ E. coli), and Fusobacterium nucleatum, members of the intestinal microbiota, are highly correlated in CRC. This review describes the roles and mechanisms of these three bacteria in CRC development. Their interaction during CRC initiation and progression has also been proposed. Our view is that in the precancerous stage of colorectal cancer, ETBF causes inflammation, leading to potential changes in intestinal ecology that may provide the basic conditions for pks+ E. coli colonization and induction of oncogenic mutations, when cancerous intestinal epithelial cells can further recruit F. nucleatum to colonise the lesion site and F. nucleatum may contribute to CRC advancement by primarily the development of cancer cells, stemization, and proliferation, which could create new and tailored preventive, screening and therapeutic interventions. However, there is the most dominant microbiota in each stage of CRC development, not neglecting the possibility that two or even all three bacteria could be engaged at any stage of the disease. The relationship between the associated gut microbiota and CRC development may provide important information for therapeutic strategies to assess the potential use of the associated gut microbiota in CRC studies, antibiotic therapy, and prevention strategies.

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