Methyldopa hepatitis

Hoyumpa, Anastacio M.; Connell, Alastair M.

doi:10.1007/bf01071975

Cited by 50 publications

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“…Although autoimmune destruction usually occurs without an identifiable trigger, some drugs including methyldopa [1] and minocycline [2] are associated with autoimmune liver disease. The antimicrobial nitrofurantoin has also rarely been implicated in autoimmune hepatitis.…”

Section: Introductionmentioning

confidence: 99%

Autoimmune hepatitis triggered by nitrofurantoin: a case series

2010

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IntroductionDrugs can occasionally trigger the onset of autoimmune liver disease.Case presentationThree Caucasian women (aged 65, 42 and 74 years old) who were receiving long-term nitrofurantoin as prophylaxis against recurrent urinary tract infections developed hepatitic liver disease. Serological auto-antibody profiles and liver histology appearances were consistent with autoimmune hepatitis. Two of the patients presented with jaundice, and one required a prolonged hospital admission for liver failure. In all three patients nitrofurantoin was withdrawn, and long-term immunosuppressive therapy with prednisolone and azathioprine or mycophenolate was given. The patients responded well, with liver biochemistry returning to normal within a few months.ConclusionsAlthough nitrofurantoin rarely causes autoimmune hepatitis, this antimicrobial is increasingly used as long-term prophylaxis against recurrent urinary tract infection. General practitioners and urologists who prescribe long-term nitrofurantoin therapy should be aware of this adverse effect.

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Section: Introductionmentioning

confidence: 99%