Methyltestosterone Therapy

Abstract

MEDBRsOH reliable to take a continuous series of instantaneous samples, say, every minute for an hour, and give the maximum, minimum, and mean values ? In addition to the questions which Dr. Handley Howell raises, data as to wind speed and weather conditions for each test would be helpful. It would also be useful to carry out the tests at various times of day, including times of peak travel. Nevertheless, the results at first sight seemed reassuring, but unfortunately Commins et al. omitted to mention that Saltzman's6 method (which they used for estimating oxides of nitrogen) is actually a method of estimating nitrogen dioxide only-it is not sensitive to nitric oxide. According to Faith7 the major component by far of oxides of nitrogen from internal combustion engines is nitric oxide. This gas is important, partly because of its direct toxic effects and partly because it is steadily converted to nitrogen dioxide in the atmosphere. This conversion may well occur more readily in tissues such as the lungs in the presence of oxidizing enzymes. Perhaps Commins et al. could give some figures for total oxides of nitrogen. I note that Commins et al. emphasize "the limited significance of the preliminary garage results." Would that much of the popular and the motor press had emphasized this instead of giving the report misleading publicity. Assuming that the London Transport Executive realizes this limited significance, surely it is its duty to admit that the diesel engine has not yet been proved harmless to health.-I am, etc., London, E.4. F. G. TOMLINS.

Blood Coagulation and Fibrinolysis in Relation to Coronary Heart Disease

“…Fihrinolysis was measured as the clot lysis time by the method described by Fearnley et al (1957) with the following modifications: (a) M/15 phosphate buffer at p3H 7.4 was used. (9.47 g. Na2HPO1/litre mixed wvith 2.27 g. KH,PO,/250 ml.)…”

Fibrinolytic Treatment of Coronary Thrombosis

“…Plasma fibrinolytic activity was estimated by a method based on that of Fearnley et al (1957) modified by Dr. A. S. Todd in order to shorten the lysis time to a more practical range and to permit the estimation to be made at leisure. To 1.7 ml.…”

Lysis of experimental thrombi by streptokinase

“…The clotting time of the whole blood with added thrombin is measured to detect any fall in blood fibrinogen. Each specimen is also checked for fibrinolytic activity by the method of Fearnley, Balmforth, and Fearnley (1957).…”